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François Schweisguth

François Schweisguth

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
11053
World Ranking
16094
National Ranking
668

Research.com Recognitions

  • 2016 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

François Schweisguth is affiliated with the Institut Pasteur in France. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cell Biology, Plant Science, Cellular and Molecular Neuroscience, and Genetics.

Their work covers key topics such as Developmental Biology and Gene Regulation, Hippo pathway signaling and YAP/TAZ, Cellular Mechanics and Interactions, Plant Molecular Biology Research, Neurobiology and Insect Physiology Research, CRISPR and Genetic Engineering, and Viral Infectious Diseases and Gene Expression in Insects.

Several recent papers illustrate the scope and direction of their research:

  • A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina (2021), published in Development.
  • Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized (2020), published in The Journal of Cell Biology.
  • HaloTag-based reporters for sparse labeling and cell tracking (2022), published in Fly.
  • Symmetry breaking and fate divergence during lateral inhibition in Drosophila (2024), published in Development.
  • Neuralized regulates a travelling wave of Epithelium-to-Neural Stem Cell morphogenesis in Drosophila (2020), published in bioRxiv (Cold Spring Harbor Laboratory).

Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Development, The Journal of Cell Biology, Fly, and Developmental Cell.

Co-authors working closely with Schweisguth include Lydie Couturier, Minh-Son Phan, Khallil Mazouni, Juan Luna-Escalante, and Claire Mestdagh, reflecting collaborations across multiple studies.

Recognition for their contributions includes membership in the Academia Europaea since 2016 and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Regulation of notch signaling activity.

    François Schweisguth

  • The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

    Magalie Lecourtois;Francois Schweisguth

  • The roles of receptor and ligand endocytosis in regulating Notch signaling.

    Roland Le Borgne;Allison Bardin;François Schweisguth

  • Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates.

    François Schweisguth;James W. Posakony

  • Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell.

    Michel Gho;Yohanns Bellaïche;François Schweisguth

  • Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference.

    Svetlana Petruk;Yurii Sedkov;Kristen M. Riley;Jacob Hodgson

  • Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division.

    Yohanns Bellaïche;Michel Gho;Julia A. Kaltschmidt;Andrea H. Brand

  • Unequal segregation of Neuralized biases Notch activation during asymmetric cell division.

    Roland Le Borgne;François Schweisguth

  • Mechanism and Significance of cis-Inhibition in Notch Signalling

    David del Álamo;David del Álamo;Hervé Rouault;Hervé Rouault;François Schweisguth;François Schweisguth

  • aPKC‐mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

    Christian A Smith;Kimberly M Lau;Zohra Rahmani;Sascha E Dho

  • The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila.

    Yohanns Bellaı̈che;Anna Radovic;Daniel F. Woods;Colleen D. Hough

  • Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.

    Véronique Morel;François Schweisguth

  • Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila

    Michel Gho;François Schweisguth

  • Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

    Magalie Lecourtois;François Schweisguth

  • Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

    Christel Brou;Frédérique Logeat;Magalie Lecourtois;Joël Vandekerckhove

  • Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.

    Roland Le Borgne;Sylvie Remaud;Sophie Hamel;François Schweisguth

  • Transcriptional control of stem cell maintenance in the Drosophila intestine

    Allison J. Bardin;Carolina N. Perdigoto;Tony D. Southall;Andrea H. Brand

  • Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila.

    Véronique Morel;Magalie Lecourtois;Olivia Massiani;Dieter Maier

  • Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis.

    François Schweisguth;James W. Posakony

  • Correction: TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

    Emmanuel Dornier;Emmanuel Dornier;Franck Coumailleau;Jean-François Ottavi;Jean-François Ottavi;Julien Moretti

Frequent Co-Authors

Yohanns Bellaïche
Yohanns Bellaïche Institute Curie
James W. Posakony
James W. Posakony University of California, San Diego
Andrea H. Brand
Andrea H. Brand University of Cambridge
Alain Israël
Alain Israël Institut Pasteur
Eric Rubinstein
Eric Rubinstein Sorbonne University
Arnaud Echard
Arnaud Echard Université Paris Cité
Claude Boucheix
Claude Boucheix University of Paris-Saclay
Domingos Henrique
Domingos Henrique University of Lisbon
Kim S. McKim
Kim S. McKim Rutgers, The State University of New Jersey
Andrew Travers
Andrew Travers MRC Laboratory of Molecular Biology

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