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D-Index & Metrics

Molecular Biology

D-Index
81
Citations
22505
World Ranking
968
National Ranking
515

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Marek Mlodzik is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on the interface of biochemistry, genetics, and molecular biology, with particular emphasis on molecular biology and cell biology as dominant subfields. Other areas of study include genetics, immunology and allergy, and cellular and molecular neuroscience.

The scientist's work centers on several main topics, including:

  • Wnt/β-catenin signaling in development and cancer
  • Hippo pathway signaling and YAP/TAZ
  • Developmental biology and gene regulation
  • Cellular mechanics and interactions
  • Cancer-related gene regulation
  • Connective tissue disorders research
  • Ubiquitin and proteasome pathways

Mlodzik has contributed extensively to the literature, with a total of 65 publications in their main field. Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory), 6 papers
  • Current Topics in Developmental Biology, 3 papers
  • SSRN Electronic Journal, 3 papers
  • eLife, 2 papers
  • Cell Reports, 2 papers

Frequent collaborators in their research include Linh T. Vuong (11 coauthored papers), Giovanna M. Collu (8 papers), Yildiz Koca (6 papers), Ashley C. Humphries (3 papers), and Claudia Molina-Pelayo (3 papers).

The following is a selection of recent papers authored or coauthored by Mlodzik:

  • "Wnt-Frizzled planar cell polarity signaling in the regulation of cell motility," 2022, Current Topics in Developmental Biology
  • "Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation," 2021, Nature Communications
  • "Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila," 2020, eLife
  • "A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled," 2023, PLoS Genetics
  • "Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response," 2022, Current Topics in Developmental Biology

Mlodzik has also been recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

    Michael Boutros;Nuria Paricio;David I Strutt;Marek Mlodzik

  • Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

    Matias Simons;Joachim Gloy;Athina Ganner;Axel Bullerkotte

  • The role of RhoA in tissue polarity and Frizzled signalling.

    David I. Strutt;Ursula Weber;Marek Mlodzik

  • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

    Hing-C. Wong;Audrey Bourdelas;Anke Krauss;Ho-Jin Lee

  • Planar Cell Polarity Signaling: From Fly Development to Human Disease

    Matias Simons;Marek Mlodzik

  • Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

    Jessica R. K. Seifert;Marek Mlodzik

  • The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates.

    Marek Mlodzik;Yasushi Hiromi;Ursula Weber;Corey S. Goodman

  • Planar cell polarity signalling couples cell division and morphogenesis during neurulation

    Brian Ciruna;Andreas Jenny;Diana Lee;Marek Mlodzik

  • Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

    Marek Mlodzik

  • Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.

    Deborah C.I. Goberdhan;Nuria Paricio;Emma C. Goodman;Marek Mlodzik

  • Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).

    Yingzi Yang;Marek Mlodzik

  • Dishevelled: at the crossroads of divergent intracellular signaling pathways

    Michael Boutros;Marek Mlodzik

  • Planar cell polarization: an emerging model points in the right direction

    Thomas J. Klein;Marek Mlodzik

  • Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.

    Nicholas E. Baker;Marek Mlodzik;Gerald M. Rubin

  • Nomenclature: Vertebrate Mediators of TGFβ Family Signals

    Rik Derynck;William M Gelbart;Richard M Harland;Carl-Henrik Heldin

  • Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis

    Marek Mlodzik;Walter J. Gehring

  • Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye.

    Manolis Fanto;Marek Mlodzik

  • Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila.

    M Mlodzik;N E Baker;G M Rubin

  • The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization.

    Fabian Feiguin;Michael Hannus;Marek Mlodzik;Suzanne Eaton

  • Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling

    Andreas Jenny;Rachel S Darken;Paul A Wilson;Marek Mlodzik

Frequent Co-Authors

Dirk Bohmann
Dirk Bohmann University of Rochester Medical Center
Michael Boutros
Michael Boutros German Cancer Research Center
David Strutt
David Strutt University of Sheffield
Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute
Walter J. Gehring
Walter J. Gehring University of Basel
Jie Zheng
Jie Zheng University of California, Los Angeles
Corey S. Goodman
Corey S. Goodman University of California, Berkeley
Sarah J. Bray
Sarah J. Bray University of Cambridge
Giulio Superti-Furga
Giulio Superti-Furga Medical University of Vienna

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