Akira Kikuchi

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Japan Leader Award
• 2025 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

  Satoshi Ikeda;Shosei Kishida;Hideki Yamamoto;Hiroshi Murai

  1617
  Citations

• Oncogenic mutations of ALK kinase in neuroblastoma.

  Yuyan Chen;Junko Takita;Young Lim Choi;Motohiro Kato

  1058
  Citations

• GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity

  Takeshi Yoshimura;Yoji Kawano;Nariko Arimura;Saeko Kawabata

  1019
  Citations

• Small GTP-binding proteins.

  Yoshimi Takai;Kozo Kaibuchi;Akira Kikuchi;Masahito Kawata

  744
  Citations

• An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

  Masatoshi Kitagawa;Shigetsugu Hatakeyama;Michiko Shirane;Masaki Matsumoto

  728
  Citations

• Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

  Shosei Kishida;Hideki Yamamoto;Satoshi Ikeda;Michiko Kishida

  659
  Citations

• Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion.

  Manabu Kurayoshi;Naohide Oue;Hideki Yamamoto;Michiko Kishida

  614
  Citations

• Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis

  Atsuhiko T. Naito;Ichiro Shiojima;Hiroshi Akazawa;Kyoko Hidaka

  602
  Citations

• Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis

  Toshiki Itoh;Seizo Koshiba;Takanori Kigawa;Akira Kikuchi

  582
  Citations

• Phosphorylation of β-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes β-Catenin through Inhibition of Its Ubiquitination

  Shin Ichiro Hino;Chie Tanji;Keiichi I. Nakayama;Akira Kikuchi

  552
  Citations

• Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction

  K.-I. Hirata;A. Kikuchi;T. Sasaki;S. Kuroda

  539
  Citations

• DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

  Shosei Kishida;Shosei Kishida;Hideki Yamamoto;Shin-ichiro Hino;Satoshi Ikeda

  522
  Citations

• Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability.

  Hideki Yamamoto;Shosei Kishida;Shosei Kishida;Michiko Kishida;Satoshi Ikeda

  504
  Citations

• The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

  Schwarz-Romond T;Fiedler M;Shibata N;Butler Pj

  460
  Citations

• Activation of Raf-1 by 14-3-3 proteins.

  Wendy J. Fantl;Anthony J. Muslin;Anthony J. Muslin;Akira Kikuchi;Jay A. Martin

  457
  Citations

• Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

  Y Fukumoto;K Kaibuchi;Y Hori;H Fujioka

  446
  Citations

• Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

  T Sasaki;A Kikuchi;S Araki;Y Hata

  422
  Citations

• Caveolin Is Necessary for Wnt-3a-Dependent Internalization of LRP6 and Accumulation of β-Catenin

  Hideki Yamamoto;Hideyuki Komekado;Akira Kikuchi

  421
  Citations

• Wnt5a regulates distinct signalling pathways by binding to Frizzled2

  Akira Sato;Hideki Yamamoto;Hiroshi Sakane;Hirofumi Koyama

  421
  Citations

• Regulation of beta-catenin signaling in the Wnt pathway.

  Akira Kikuchi

  421
  Citations