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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
113
Citations
42473
World Ranking
864
National Ranking
59

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2003 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Klaus Aktories is affiliated with the University of Freiburg in Germany. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on subfields such as Infectious Diseases, Immunology, Molecular Biology, Genetics, and Emergency Medical Services.

The scientist has contributed extensively to topics including Clostridium difficile and Clostridium perfringens research, Toxin Mechanisms and Immunotoxins, Bacillus and Francisella bacterial research, Viral gastroenteritis research and epidemiology, Bacterial Genetics and Biotechnology, Yersinia bacterium, plague, ectoparasites research, and Pediatric health and respiratory diseases.

Their recent publications include the following papers:

  • Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT, 2020, The FASEB Journal
  • Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state, 2020, PLoS Pathogens
  • Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT, 2020, Frontiers in Pharmacology
  • Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response, 2020, The Journal of Infectious Diseases
  • Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins, 2020, Science Advances

Klaus Aktories frequently collaborates with several co-authors, including Panagiotis Papatheodorou, Carsten Schwan, Alexander E. Lang, Holger Barth, and Stephan Fischer.

Their work has appeared multiple times in notable publication venues such as Naunyn-Schmiedeberg s Archives of Pharmacology, bioRxiv (Cold Spring Harbor Laboratory), The FASEB Journal, PLoS Pathogens, and Frontiers in Pharmacology.

Klaus Aktories has been recognized with membership in the German National Academy of Sciences Leopoldina since 2003 under the category of Physiology and Pharmacology/Toxicology. Additionally, they are a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Glucosylation of Rho proteins by Clostridium difficile toxin B

    I. Just;J. Selzer;M. Wilm;C. von Eichel-Streiber

  • Microinjection of recombinant p21rho induces rapid changes in cell morphology.

    H F Paterson;A J Self;M D Garrett;I Just

  • SUSTAINED SIGNALING LEADING TO T CELL ACTIVATION RESULTS FROM PROLONGED T CELL RECEPTOR OCCUPANCY. ROLE OF T CELL ACTIN CYTOSKELETON

    Salvatore Valitutti;Mark Dessing;Klaus Aktories;Harald Gallati

  • Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1

    Gudula Schmidt;Peter Sehr;Matthias Wilm;Jörg Selzer

  • Botulinum C2 toxin ADP-ribosylates actin

    K. Aktories;M. Bärmann;I. Ohishi;S. Tsuyama

  • Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.

    Supriya Srinivasan;Fei Wang;Suzana Glavas;Alexander Ott

  • The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.

    Ingo Just;Matthias Wilm;Jörg Selzer;Gundula Rex

  • Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins

    Holger Barth;Klaus Aktories;Michel R. Popoff;Bradley G. Stiles

  • Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

    Siegfried Wahl;Holger Barth;Thomas Ciossek;Klaus Aktories

  • Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance

    Dale N Gerding;Stuart Johnson;Maja Rupnik;Klaus Aktories

  • Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.

    Carsten Schwan;Bärbel Stecher;Tina Tzivelekidis;Marco van Ham

  • GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.

    Ulrich Von Pawel-Rammingen;Maxim V. Telepnev;Gudula Schmidt;Klaus Aktories

  • Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O.

    Iwan Walev;Sebastian Chakrit Bhakdi;Fred Hofmann;Nabil Djonder

  • The N-terminal Domain of Pseudomonas aeruginosaExoenzyme S Is a GTPase-activating Protein for Rho GTPases

    Udo-Michael Goehring;Gudula Schmidt;Kristin J. Pederson;Klaus Aktories

  • Bacterial protein toxins that modify host regulatory GTPases

    Klaus Aktories

  • Bacterial cytotoxins: targeting eukaryotic switches

    Klaus Aktories;Joseph T. Barbieri

  • Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

    Thomas Jank;Klaus Aktories

  • The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3

    Klaus Aktories;Ulrich Braun;Sigrid Rösener;Ingo Just

  • Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin

    Klaus Aktories;Ulrich Weller;Gursharan S. Chhatwal

  • Clostridium difficile Toxin Biology.

    Klaus Aktories;Carsten Schwan;Thomas Jank

Frequent Co-Authors

Holger Barth
Holger Barth University of Ulm
Ingo Just
Ingo Just Hannover Medical School
Karl H. Jakobs
Karl H. Jakobs University of Duisburg-Essen
Roland Benz
Roland Benz Jacobs University
Michel R. Popoff
Michel R. Popoff Institut Pasteur
Joseph T. Barbieri
Joseph T. Barbieri Medical College of Wisconsin
Matthias Wilm
Matthias Wilm University College Dublin
Joël Vandekerckhove
Joël Vandekerckhove Ghent University
Werner Seeger
Werner Seeger University of Giessen
Alan Hall
Alan Hall Memorial Sloan Kettering Cancer Center

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