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Immunology

D-Index
102
Citations
40718
World Ranking
670
National Ranking
388

Overview

Dennis M. Klinman is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on immunology and microbiology, with 17 publications in this field, alongside contributions in medicine and biochemistry, genetics, and molecular biology. Klinman's work extends into several subfields including immunology, molecular biology, epidemiology, pulmonary and respiratory medicine, and psychiatry and mental health.

The scientist's research encompasses a variety of topics, prominently featuring immune response and inflammation, inflammasome and immune disorders, immune cells in cancer, neutrophil, myeloperoxidase and oxidative mechanisms, interferon and immune responses, sepsis diagnosis and treatment, and inflammation biomarkers and pathways.

Recent publications include:

  • "Immunotherapy in sepsis - brake or accelerate?" (2020) in Pharmacology & Therapeutics
  • "CpG Oligonucleotides as Vaccine Adjuvants" (2020) in Methods in Molecular Biology
  • "Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury" (2021) in American Journal of Respiratory and Critical Care Medicine
  • "STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis" (2021) in Gut
  • "The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation" (2020) in Scientific Reports

The frequent co-authors collaborating with Klinman include Folkert Steinhagen, Christian Bode, Konrad Peukert, Neslihan Kayraklioglu, and Begum Horuluoglu. These collaborations highlight a network of researchers contributing jointly to the scientific investigations in their shared fields of study.

Klinman has contributed to multiple publications in the following venues:

  • Scientific Reports (2 publications)
  • Pharmacology & Therapeutics
  • Methods in Molecular Biology
  • American Journal of Respiratory and Critical Care Medicine
  • Gut

Best Publications

  • CPG MOTIFS IN BACTERIAL DNA TRIGGER DIRECT B-CELL ACTIVATION

    Arthur M. Krieg;Ae-Kyung Yi;Sara Matson;Thomas J. Waldschmidt

  • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

    Dennis M. Klinman;Ae-Kyung Yi;Serge L. Beaucage;Jacqueline Conover

  • DNA vaccines: immunology, application, and optimization*.

    Sanjay Gurunathan;Dennis M. Klinman;Robert A. Seder

  • Immunotherapeutic uses of CpG oligodeoxynucleotides

    Dennis M. Klinman

  • CpG DNA as a vaccine adjuvant

    Christian Bode;Gan Zhao;Folkert Steinhagen;Takeshi Kinjo

  • Contribution of CpG motifs to the immunogenicity of DNA vaccines.

    D M Klinman;G Yamshchikov;Y Ishigatsubo

  • Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

    Fumihiko Takeshita;Cynthia A. Leifer;Ihsan Gursel;Ken J. Ishii

  • Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs

    Daniela Verthelyi;Ken J. Ishii;Mayda Gursel;Fumihiko Takeshita

  • TLR-based immune adjuvants.

    Folkert Steinhagen;Takeshi Kinjo;Christian Bode;Dennis M. Klinman

  • CpG motifs as immune adjuvants.

    Dennis M. Klinman;Kerry M. Barnhart;Jacqueline Conover

  • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria.

    Karen L. Elkins;Tonya R. Rhinehart-Jones;Scott Stibitz;Jacqueline S. Conover

  • Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides.

    Sanjiv Sur;James S. Wild;Barun K. Choudhury;Nilanjana Sur

  • Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway.

    A K Yi;D M Klinman;T L Martin;S Matson

  • Use of CpG oligodeoxynucleotides as immune adjuvants

    Dennis M. Klinman;Debra Currie;Ihsan Gursel;Daniela Verthelyi

  • Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer.

    Julia Scheiermann;Dennis M. Klinman

  • Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

    Yuko Shirota;Hidekazu Shirota;Dennis M. Klinman

  • Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.

    Guizhi Zhu;Geoffrey M. Lynn;Orit Jacobson;Kai Chen

  • Repetitive Elements in Mammalian Telomeres Suppress Bacterial DNA-Induced Immune Activation

    Ihsan Gursel;Mayda Gursel;Hiroshi Yamada;Ken J. Ishii

  • Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: Interferon-γ–secreting cells in the peripheral blood

    Eri Hagiwara;Mark F. Gourley;Susie Lee;Dennis M. Klinman

  • Systemic autoimmune disease arises from polyclonal B cell activation

    Unknown

  • Genomic DNA Released by Dying Cells Induces the Maturation of APCs

    Ken J. Ishii;Koichi Suzuki;Cevayir Coban;Fumihiko Takeshita

Frequent Co-Authors

Ken J. Ishii
Ken J. Ishii University of Tokyo
Kenji Okuda
Kenji Okuda Yokohama City University
Alfred D. Steinberg
Alfred D. Steinberg Mitre (United States)
Arthur M. Krieg
Arthur M. Krieg University of Massachusetts Chan Medical School
Norihisa Ishii
Norihisa Ishii National Institutes of Biomedical Innovation, Health and Nutrition
Hiroshi Yamada
Hiroshi Yamada Okayama University
Cevayir Coban
Cevayir Coban University of Tokyo
Igal Gery
Igal Gery National Institutes of Health
Shizuo Akira
Shizuo Akira Osaka University

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