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Biology and Biochemistry

D-Index
71
Citations
17166
World Ranking
6685
National Ranking
3108

Research.com Recognitions

  • 2008 - Fellow of the American Academy of Arts and Sciences
  • 1999 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Mary C. Beckerle is affiliated with the University of Utah in the United States. Their research spans multiple fields, focusing extensively on biochemistry, genetics, molecular biology, and medicine. Their work also intersects with various specialized subfields including molecular biology, cell biology, oncology, cardiology and cardiovascular medicine, as well as atomic and molecular physics and optics.

The core topics of Beckerle's research include cellular mechanics and interactions, nuclear structure and function, RNA research and splicing, cardiomyopathy and myosin studies, force microscopy techniques and applications, colorectal cancer screening and detection, and global cancer incidence and screening.

They have published numerous papers in prominent scientific journals. Some recent notable publications include:

  • "Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains," 2020, Developmental Cell
  • "Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes," 2020, Molecular Biology of the Cell
  • "Screen to Save: Results from NCI's Colorectal Cancer Outreach and Screening Initiative to Promote Awareness and Knowledge of Colorectal Cancer in Racial/Ethnic and Rural Populations," 2020, Cancer Epidemiology Biomarkers & Prevention
  • "Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility," 2022, Molecular Biology of the Cell
  • "Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha," 2020, Scientific Reports

Frequent collaborators in Beckerle's work include Elizabeth Blankman, Mark A. Smith, Laura Hoffman, Christopher C. Jensen, and Xiaoyu Sun. This network of co-authors reflects their interdisciplinary approach to research in molecular and cellular biology.

Mary C. Beckerle's publications appear primarily in venues such as Molecular Biology of the Cell, Developmental Cell, Cancer Epidemiology Biomarkers & Prevention, Scientific Reports, and Heliyon, illustrating a breadth of contributions across biology and cancer-related research.

Throughout their career, Beckerle has been recognized with awards including the Fellow of the American Academy of Arts and Sciences in 2008 and the Fellowship of the John Simon Guggenheim Memorial Foundation awarded in 1999.

Best Publications

  • Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

    Alan Horwitz;Kimberly Duggan;Clayton Buck;Mary C. Beckerle

  • The LIM domain: from the cytoskeleton to the nucleus

    Julie L. Kadrmas;Mary C. Beckerle

  • Striated muscle cytoarchitecture: an intricate web of form and function.

    Kathleen A. Clark;Abigail S. McElhinny;Mary C. Beckerle;Carol C. Gregorio

  • The LIM domain is a modular protein-binding interface

    Karen L. Schmeichel;Mary C. Beckerle

  • Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

    Masaaki Yoshigi;Masaaki Yoshigi;Laura M. Hoffman;Laura M. Hoffman;Christopher C. Jensen;H. Joseph Yost;H. Joseph Yost

  • Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.

    Ingrid Sadler;Aaron W. Crawford;James W. Michelsen;Mary C. Beckerle

  • Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

    Mary C. Beckerle;Keith Burridge;George N. DeMartino;Dorothy E. Croall

  • An interaction between zyxin and alpha-actinin.

    Aaron W. Crawford;James W. Michelsen;Mary C. Beckerle

  • Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: A potential mechanism for communication between sites of cell adhesion and the nucleus

    David A. Nix;Mary C. Beckerle

  • Cysteine-Rich LIM-Only Proteins CRP1 and CRP2 Are Potent Smooth Muscle Differentiation Cofactors

    David F. Chang;Narasimhaswamy S. Belaguli;Dinakar Iyer;Wilmer B. Roberts

  • Zyxin: zinc fingers at sites of cell adhesion.

    Mary C. Beckerle

  • A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

    Oliver Hobert;Donald G. Moerman;Kathleen A. Clark;Mary C. Beckerle

  • Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP.

    Gabriela C. Pérez-Alvarado;Colleen Miles;James W. Michelsen;Heather A. Louis

  • Comparison of Three Members of the Cysteine-rich Protein Family Reveals Functional Conservation and Divergent Patterns of Gene Expression

    Heather A. Louis;Josephine D. Pino;Karen L. Schmeichel;Pascal Pomiès

  • A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair

    Mark A. Smith;Elizabeth Blankman;Margaret L. Gardel;Laura Luettjohann

  • Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions.

    Aaron W. Crawford;Mary C. Beckerle

  • The kindler syndrome protein is regulated by transforming growth factor-β and involved in integrin-mediated adhesion

    Susanne Kloeker;Michael B. Major;David A. Calderwood;Mark H. Ginsberg

  • Targeting of Zyxin to Sites of Actin Membrane Interaction and to the Nucleus

    David A. Nix;Julie Fradelizi;Susanne Bockholt;Bernadette Menichi

  • Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

    Kristi L. Neufeld;David A. Nix;Hal Bogerd;Yibin Kang

  • Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy

    Mohammad Pashmforoush;Pascal Pomiès;Kirk L. Peterson;Steve Kubalak

Frequent Co-Authors

Dennis R. Winge
Dennis R. Winge University of Utah
Stephen L. Lessnick
Stephen L. Lessnick Nationwide Children's Hospital
Keith Burridge
Keith Burridge University of North Carolina at Chapel Hill
Alana L. Welm
Alana L. Welm University of Utah
Michael F. Summers
Michael F. Summers University of Maryland, Baltimore County
Ulrich Walter
Ulrich Walter Johannes Gutenberg University of Mainz
Kenneth R. Chien
Kenneth R. Chien Karolinska Institute
Nancy R. Zahniser
Nancy R. Zahniser University of Colorado Denver
Oliver Hobert
Oliver Hobert Columbia University
Charles Auffray
Charles Auffray Centre national de la recherche scientifique, CNRS

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