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D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
17234
World Ranking
5687
National Ranking
2696

Overview

Chuanyue Wu is affiliated with the University of Pittsburgh in the United States and has an extensive publication record in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research primarily spans Molecular Biology, Cell Biology, Immunology and Allergy, Pulmonary and Respiratory Medicine, and Oncology.

Their work addresses several specialized topics including Cell Adhesion Molecules Research, Cellular Mechanics and Interactions, Ubiquitin and proteasome pathways, Caveolin-1 and cellular processes, Cancer, Hypoxia, and Metabolism, Wnt/β-catenin signaling in development and cancer, and Cancer Cells and Metastasis.

Chuanyue Wu has published research in a variety of scientific venues. Frequent publication outlets include Theranostics, Bone Research, Nature Communications, Cellular and Molecular Life Sciences, and Current Research in Cell Biology.

Among recent papers, notable works include:

  • "Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice," published in Bone Research, 2020
  • "PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth," published in Nature Communications, 2020
  • "Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice," published in Nature Communications, 2020
  • "Extracellular matrix stiffness regulates mitochondrial dynamics through PINCH-1- and kindlin-2-mediated signalling," published in Current Research in Cell Biology, 2021
  • "Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression," published in American Journal of Respiratory Cell and Molecular Biology, 2021

Collaborations are a substantial part of Chuanyue Wu's research, with frequent coauthors including Ling Guo, Yi Deng, Ying Sun, Jiaxin Wang, and Chengmin Liu.

Best Publications

  • Breaking the Integrin Hinge A DEFINED STRUCTURAL CONSTRAINT REGULATES INTEGRIN SIGNALING

    Paul E. Hughes;Federico Diaz-Gonzalez;Lilley Leong;Chuanyue Wu

  • Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

    Chuanyue Wu;Shoukat Dedhar

  • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.

    Yingjian Li;Junwei Yang;Chunsun Dai;Chuanyue Wu

  • Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.

    Yizeng Tu;Shan Wu;Xiaohua Shi;Ka Chen

  • Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix.

    Chuanyue Wu;V. M. Keivens;T. E. O'toole;J. A. Mcdonald

  • Kindlin-2 (Mig-2): a co-activator of β3 integrins

    Yan Qing Ma;Jun Qin;Chuanyue Wu;Edward F. Plow

  • Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity

    Chuanyue Wu;Sarah Y. Keightley;Chungyee Leung-Hagesteijn;Galena Radeva

  • The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells.

    Yizeng Tu;Fugang Li;Silvia Goicoechea;Chuanyue Wu

  • A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.

    Yizeng Tu;Yao Huang;Yongjun Zhang;Yun Hua

  • PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

    Tomohiko Fukuda;Ka Chen;Xiaohua Shi;Chuanyue Wu

  • Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats.

    F. Li;Y. Zhang;C. Wu

  • Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

    Hannu Larjava;Edward F Plow;Chuanyue Wu

  • Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways

    Yizeng Tu;Fugang Li;Chuanyue Wu

  • The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

    Koichi Fukuda;Sudhiranjan Gupta;Ka Chen;Chuanyue Wu

  • Kindlin-2 links mechano-environment to proline synthesis and tumor growth

    Ling Guo;Chunhong Cui;Kuo Zhang;Jiaxin Wang

  • The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

    Chuanyue Wu;J. S. Bauer;R. L. Juliano;J. A. Mcdonald

  • Assembly of extracellular matrix

    Deane F. Mosher;Jane Sottile;Chuanyue Wu;John A. McDonald

  • Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites.

    Yongjun Zhang;Ka Chen;Yizeng Tu;Algirdas Velyvis

  • The PINCH–ILK–parvin complexes: assembly, functions and regulation

    Chuanyue Wu

  • The MIG-2/Integrin Interaction Strengthens Cell-Matrix Adhesion and Modulates Cell Motility

    Xiaohua Shi;Yan Qing Ma;Yizeng Tu;Ka Chen

Frequent Co-Authors

Jun Qin
Jun Qin Cleveland Clinic Lerner College of Medicine
Guozhi Xiao
Guozhi Xiao Southern University of Science and Technology
George K. Michalopoulos
George K. Michalopoulos University of Pittsburgh
Shoukat Dedhar
Shoukat Dedhar University of British Columbia
Hannu Larjava
Hannu Larjava University of British Columbia
Di Chen
Di Chen Chinese Academy of Sciences
Edward F. Plow
Edward F. Plow Cleveland Clinic Lerner College of Medicine
Youhua Liu
Youhua Liu University of Pittsburgh
Qimin Zhan
Qimin Zhan Peking University Stomatological Hospital
Matthias Kretzler
Matthias Kretzler University of Michigan–Ann Arbor

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