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Molecular Biology

D-Index
46
Citations
14286
World Ranking
2776
National Ranking
218

Overview

Thomas A. Milne is affiliated with the University of Oxford in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. They have published extensively in molecular biology and hematology, along with work related to public health, environmental and occupational health, immunology, and genetics.

Their main topics of research encompass acute myeloid leukemia, protein degradation and inhibitors, acute lymphoblastic leukemia, genomics and chromatin dynamics, histone deacetylase inhibitors, epigenetics and DNA methylation, as well as RNA and protein synthesis mechanisms.

Frequent coauthors include Nicholas T. Crump, Alastair Smith, Anindita Roy, Thomas Jackson, and Irene Roberts, indicating active collaborations within their research community.

Thomas A. Milne has contributed to several recent papers, including:

  • Defining genome architecture at base-pair resolution (2021, Nature)
  • BET inhibition disrupts transcription but retains enhancer-promoter contact (2021, Nature Communications)
  • H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells (2020, Leukemia)
  • Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture (2022, Nature Protocols)
  • Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation (2021, Cell Reports)

Their work has been published frequently in the following venues:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Experimental Hematology
  • Leukemia

Best Publications

  • A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

    Joanna Wysocka;Tomek Swigut;Hua Xiao;Thomas A. Milne

  • MLL targets SET domain methyltransferase activity to Hox gene promoters.

    Thomas A Milne;Scott D Briggs;Hugh W Brock;Mary Ellen Martin

  • WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development

    Joanna Wysocka;Tomek Swigut;Thomas A. Milne;Yali Dou

  • Regulation of MLL1 H3K4 methyltransferase activity by its core components

    Yali Dou;Thomas A Milne;Alexander J Ruthenburg;Alexander J Ruthenburg;Seunghee Lee

  • Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF

    Yali Dou;Thomas A. Milne;Thomas A. Milne;Alan J. Tackett;Edwin R. Smith

  • Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus

    Christina M. Hughes;Orit Rozenblatt-Rosen;Thomas A. Milne;Terry D. Copeland

  • RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

    Jaehoon Kim;Mohamed Guermah;Robert K. McGinty;Jung Shin Lee

  • Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

    Thomas A. Milne;Christina M. Hughes;Ricardo Lloyd;Zhaohai Yang

  • Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

    Alexander J. Ruthenburg;Haitao Li;Thomas A. Milne;Scott Dewell

  • Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

    Altuna Akalin;Francine E. Garrett-Bakelman;Matthias Kormaksson;Jennifer Busuttil

  • Intragenic Enhancers Act as Alternative Promoters

    Monika S. Kowalczyk;Jim R. Hughes;David Garrick;Magnus D. Lynch

  • MLL associates specifically with a subset of transcriptionally active target genes

    Thomas A. Milne;Yali Dou;Mary Ellen Martin;Hugh W. Brock

  • Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

    Thomas A. Milne;Jaehoon Kim;Gang G. Wang;Sonja C. Stadler

  • Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

    Zhanxin Wang;Jikui Song;Thomas A. Milne;Gang G. Wang

  • Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications

    Thomas A. Milne;Mary Ellen Martin;Hugh W. Brock;Robert K. Slany

  • Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation

    Corrado Caslini;Zhaohai Yang;Mohamad El-Osta;Thomas A. Milne

  • MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

    Vaia Stavropoulou;Susanne Kaspar;Susanne Kaspar;Laurent Brault;Mathijs A. Sanders

  • Metabolic gatekeeper function of B-lymphoid transcription factors

    Lai N. Chan;Zhengshan Chen;Daniel Braas;Jae Woong Lee

  • Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

    Mary Ellen Martin;Thomas A Milne;Thomas A Milne;Sebastien Bloyer;Karine Galoian

  • Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

    Debabrata Biswas;Thomas A. Milne;Thomas A. Milne;Venkatesha Basrur;Jaehoon Kim

Frequent Co-Authors

Markus Müschen
Markus Müschen Yale University
Robert G. Roeder
Robert G. Roeder Rockefeller University
C. David Allis
C. David Allis Rockefeller University
Jay L. Hess
Jay L. Hess Indiana University
Paresh Vyas
Paresh Vyas University of Oxford
Irene Roberts
Irene Roberts University of Oxford
Ari Melnick
Ari Melnick Cornell University
James Hughes
James Hughes Emory University
Yali Dou
Yali Dou University of Southern California
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center

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