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Best Scientists
2025
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Molecular Biology
USA
2023

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Best Scientists

D-Index
178
Citations
155000
World Ranking
642
National Ranking
401

Molecular Biology

D-Index
180
Citations
159451
World Ranking
34
National Ranking
23

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2019 - Member of the National Academy of Medicine (NAM)
  • 2018 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2016 - Gruber Prize in Genetics
  • 2015 - Breakthrough Prize in Life Sciences for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization, advancing the understanding of diseases ranging from birth defects to cancer.
  • 2014 - Japan Prize for the discovery of histone modifications as fundamental regulators of gene expression.
  • 2007 - Canada Gairdner International Award
  • 2005 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Academy of Arts and Sciences

Overview

C. David Allis was affiliated with Rockefeller University in the United States. Their research primarily focused on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to subfields including Molecular Biology, Genetics, Cancer Research, Oncology, and Hematology.

The scientist's work encompassed several main topics, including:

  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Protein Degradation and Inhibitors
  • RNA Modifications and Cancer
  • Cancer-related Gene Regulation
  • Histone Deacetylase Inhibitors Research
  • Gut Microbiota and Health

Their recent papers demonstrate a focus on chromatin regulation and cancer biology, with titles, publication years, and venues as follows:

  • "The language of chromatin modification in human cancers" (2021) published in Nature reviews. Cancer
  • "Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture" (2020) published in Nature
  • "The epigenomics of sarcoma" (2020) published in Nature reviews. Cancer
  • "Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors" (2020) published in Cell Host & Microbe
  • "Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response" (2020) published in Cancer Cell

The scientist frequently published in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Nature reviews. Cancer
  • Nature

Key collaborators included:

  • Alexey A. Soshnev
  • Douglas Barrows
  • Leah Gates
  • Benjamin A. García
  • Scott W. Lowe

The scientist was recognized with multiple awards throughout their career:

  • Member of the National Academy of Medicine (NAM) in 2019
  • Albert Lasker Award for Basic Medical Research in 2018
  • Gruber Prize in Genetics in 2016
  • Breakthrough Prize in Life Sciences in 2015 for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization, advancing the understanding of diseases ranging from birth defects to cancer
  • Japan Prize in 2014 for the discovery of histone modifications as fundamental regulators of gene expression
  • Canada Gairdner International Award in 2007
  • Member of the National Academy of Sciences in 2005
  • Fellow of the American Academy of Arts and Sciences in 2001

Best Publications

  • Translating the Histone Code

    Thomas Jenuwein;C. David Allis

  • The language of covalent histone modifications.

    B D Strahl;C D Allis

  • Regulation of chromatin structure by site-specific histone H3 methyltransferases

    S Rea;F Eisenhaber;D O'Carroll;B D Strahl

  • Epigenetics: A Landscape Takes Shape

    Aaron D. Goldberg;C. David Allis;Emily Bernstein

  • The molecular hallmarks of epigenetic control

    C. David Allis;Thomas Jenuwein

  • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation.

    M J Hendzel;Y Wei;M A Mancini;A Van Hooser

  • Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

    Jun-ichi Nakayama;Judd C. Rice;Brian D. Strahl;C. David Allis

  • DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

    Steen K.T. Ooi;Chen Qiu;Emily Bernstein;Keqin Li

  • How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

    Sean D Taverna;Haitao Li;Alexander J Ruthenburg;C David Allis

  • Roles of histone acetyltransferases and deacetylases in gene regulation

    Min Hao Kuo;C. David Allis

  • Steroid receptor coactivator-1 is a histone acetyltransferase

    T E Spencer;G Jenster;G Jenster;M M Burcin;C D Allis

  • Histone and chromatin cross-talk.

    Wolfgang Fischle;Yanming Wang;C David Allis

  • Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

    Yanming Wang;Ming‐ming Li;Sonja Stadler;Sonja Stadler;Sarah Correll

  • A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

    Joanna Wysocka;Tomek Swigut;Hua Xiao;Thomas A. Milne

  • Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

    Peter W. Lewis;Manuel M. Müller;Matthew S. Koletsky;Francisco Cordero

  • Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

    Zu-Wen Sun;C. David Allis

  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

    Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis

  • Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

    P A Grant;L Duggan;J Côté;S M Roberts

  • Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark

    Alexander J. Ruthenburg;C. David Allis;Joanna Wysocka

  • Signaling to Chromatin through Histone Modifications

    Peter Cheung;C.David Allis;Paolo Sassone-Corsi

Frequent Co-Authors

Haitao Li
Haitao Li Tsinghua University
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
Donald F. Hunt
Donald F. Hunt University of Virginia
Robert G. Roeder
Robert G. Roeder Rockefeller University
Jeffrey Shabanowitz
Jeffrey Shabanowitz University of Virginia
Brian D. Strahl
Brian D. Strahl University of North Carolina at Chapel Hill
Thomas A. Milne
Thomas A. Milne University of Oxford
Tom W. Muir
Tom W. Muir Princeton University
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center
Chao Lu
Chao Lu Hong Kong Polytechnic University

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Best Scientists Citing C. David Allis