World's Best Scientists 2026 revealed!
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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
134
Citations
101894
World Ranking
153
National Ranking
99

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award

Overview

Yi Zhang is affiliated with Harvard University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields, with a significant focus on molecular biology, oncology, immunology, pulmonary and respiratory medicine, and cancer research.

The scientist's work covers a broad array of topics including epigenetics and DNA methylation, cancer immunotherapy and biomarkers, ferroptosis and cancer prognosis, RNA modifications and cancer, protein degradation and inhibitors, single-cell and spatial transcriptomics, and immune cells in cancer.

Zhang's recent publications include:

  • Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade (2021, Cancer Discovery)
  • In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target (2021, Cell)
  • MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets (2022, Nature Communications)
  • TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response (2021, Nucleic Acids Research)
  • Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis (2024, Journal of Hematology & Oncology)

Their frequent coauthors include Shengqing Gu, Zexian Zeng, Myles Brown, X. Shirley Liu, and Jingxin Fu.

Yi Zhang publishes regularly in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Cancer Research, Journal of Medicinal Chemistry, and Blood.

Best Publications

  • Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

    Ru Cao;Liangjun Wang;Hengbin Wang;Li Xia

  • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

    F. Ann Ran;Patrick D. Hsu;Chie Yu Lin;Jonathan S. Gootenberg

  • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

    Shinsuke Ito;Li Shen;Qing Dai;Susan C. Wu

  • Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

    Wei Xu;Hui Yang;Ying Liu;Ying Yang

  • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

    Shinsuke Ito;Ana C. D’Alessio;Ana C. D’Alessio;Olena V. Taranova;Olena V. Taranova;Kwonho Hong;Kwonho Hong

  • Histone demethylation by a family of JmjC domain-containing proteins

    Yu Ichi Tsukada;Jia Fang;Jia Fang;Hediye Erdjument-Bromage;Maria E. Warren

  • The diverse functions of histone lysine methylation.

    Cyrus Martin;Yi Zhang

  • Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

    Yi Zhang;Danny Reinberg

  • Role of histone H2A ubiquitination in Polycomb silencing

    Hengbin Wang;Liangjun Wang;Hediye Erdjument-Bromage;Miguel Vidal

  • TET enzymes, TDG and the dynamics of DNA demethylation

    Rahul M. Kohli;Yi Zhang

  • Role of histone H3 lysine 27 methylation in X inactivation.

    Kathrin Plath;Jia Fang;Susanna K. Mlynarczyk-Evans;Ru Cao

  • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

    Yi Zhang;Huck-Hui Ng;Hediye Erdjument-Bromage;Paul Tempst

  • JmjC-domain-containing proteins and histone demethylation.

    Robert J. Klose;Eric M. Kallin;Yi Zhang

  • TET-mediated active DNA demethylation: mechanism, function and beyond

    Xiaoji Wu;Yi Zhang

  • Active DNA demethylation: many roads lead to Rome

    Susan C. Wu;Yi Zhang

  • The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

    P. P. Hsu;S. A. Kang;J. Rameseder;Y. Zhang

  • MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.

    Huck-Hui Ng;Yi Zhang;Brian Hendrich;Colin A Johnson

  • New nomenclature for chromatin-modifying enzymes.

    C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent

  • Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

    Hao Wu;Yi Zhang

  • The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

    Ru Cao;Yi Zhang

Frequent Co-Authors

Li Shen
Li Shen Icahn School of Medicine at Mount Sinai
Paul Tempst
Paul Tempst Memorial Sloan Kettering Cancer Center
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University
Hao Wu
Hao Wu Harvard University
Jun Hu
Jun Hu Chinese Academy of Sciences
Patty J. Lee
Patty J. Lee Duke University
Danny Reinberg
Danny Reinberg University of Miami
Jarrod A. Marto
Jarrod A. Marto Harvard University
Sheng-Cai Lin
Sheng-Cai Lin Xiamen University
Wei Jiang
Wei Jiang Wuhan University

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