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2025
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Molecular Biology
USA
2026

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Best Scientists

D-Index
172
Citations
129400
World Ranking
801
National Ranking
483

Molecular Biology

D-Index
172
Citations
127202
World Ranking
43
National Ranking
29

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award

Overview

Paul Tempst is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology and various medical subfields including geriatrics, gerontology, oncology, pulmonary and respiratory medicine, and rheumatology.

The scientist's work centers on topics related to epigenetics and DNA methylation, histone deacetylase inhibitors research, DNA repair mechanisms, sirtuins and resveratrol in medicine, PARP inhibition in cancer therapy, cancer-related gene regulation, and prostate cancer treatment and research.

Frequent publication venues for their research include:

  • UNC Libraries
  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Key recent papers authored or co-authored by Paul Tempst include:

  • Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain, 2021, UNC Libraries
  • Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage, 2021, UNC Libraries
  • Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase, 2021, UNC Libraries
  • PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation, 2021, UNC Libraries
  • JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor, 2021, UNC Libraries

Collaborations have been an important aspect of Tempst's research, with frequent coauthors including:

  • Hediye Erdjument-Bromage
  • Hengbin Wang
  • Ru Cao
  • Xia Li
  • Kenichi Yamane

Best Publications

  • Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

    Ru Cao;Liangjun Wang;Hengbin Wang;Li Xia

  • SNAP receptors implicated in vesicle targeting and fusion

    Thomas Söllner;Sidney W. Whiteheart;Michael Brunner;Hediye Erdjument-Bromage

  • mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

    Do Hyung Kim;Dos D. Sarbassov;Siraj M. Ali;Jessie E. King

  • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

    Dos D. Sarbassov;Siraj M Ali;Do-Hyung Kim;David A Guertin

  • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

    Kornelia Polyak;Mong Hong Lee;Hediye Erdjument-Bromage;Andrew Koff

  • PRDM16 controls a brown fat/skeletal muscle switch

    Patrick Seale;Bryan Bjork;Wenli Yang;Shingo Kajimura

  • Histone demethylation by a family of JmjC domain-containing proteins

    Yu Ichi Tsukada;Jia Fang;Jia Fang;Hediye Erdjument-Bromage;Maria E. Warren

  • Role of histone H2A ubiquitination in Polycomb silencing

    Hengbin Wang;Liangjun Wang;Hediye Erdjument-Bromage;Miguel Vidal

  • A cellular gene encodes scrapie PrP 27-30 protein

    Bruno Oesch;Bruno Oesch;David Westaway;Monika Wälchli;Monika Wälchli;Michael P. McKinley

  • RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

    David M. Sabatini;Hediye Erdjument-Bromage;Mary Lui;Paul Tempst

  • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

    Andrei Kuzmichev;Kenichi Nishioka;Hediye Erdjument-Bromage;Paul Tempst

  • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

    A. Phillip West;Igor E. Brodsky;Igor E. Brodsky;Christoph Rahner;Dong Kyun Woo

  • DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

    Steen K.T. Ooi;Chen Qiu;Emily Bernstein;Keqin Li

  • Protein S-nitrosylation: a physiological signal for neuronal nitric oxide.

    Samie R. Jaffrey;Hediye Erdjument-Bromage;Christopher D. Ferris;Paul Tempst

  • Phosphorylation and Functional Inactivation of TSC2 by Erk: Implications for Tuberous Sclerosis and Cancer Pathogenesis

    Li Ma;Zhenbang Chen;Hediye Erdjument-Bromage;Paul Tempst;Paul Tempst

  • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

    Yi Zhang;Huck-Hui Ng;Hediye Erdjument-Bromage;Paul Tempst

  • Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

    Len Stephens;Karen Anderson;David Stokoe;Hediye Erdjument-Bromage

  • Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death.

    Atan Gross;Xiao Ming Yin;Kun Wang;Michael C. Wei

  • Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

    Santiago Lamas;Philip A. Marsden;Gordon K. Li;Paul Tempst

  • GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

    Do Hyung Kim;Dos D. Sarbassov;Siraj M. Ali;Robert R. Latek

Frequent Co-Authors

Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University
Yi Zhang
Yi Zhang Harvard University
Danny Reinberg
Danny Reinberg University of Miami
Bradley R. Cairns
Bradley R. Cairns University of Utah
Jesper Q. Svejstrup
Jesper Q. Svejstrup University of Copenhagen
Thomas A. Neubert
Thomas A. Neubert New York University
Roger D. Kornberg
Roger D. Kornberg Stanford University
Steven A. Carr
Steven A. Carr Broad Institute
daniel c liebler
daniel c liebler Vanderbilt University
Susan J. Fisher
Susan J. Fisher University of California, San Francisco

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