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Andrés Aguilera

Andrés Aguilera

D-Index & Metrics

Genetics

D-Index
89
Citations
27526
World Ranking
1127
National Ranking
15

Overview

Andrés Aguilera is affiliated with the University of Seville in Spain and has a significant body of work within the domain of Biochemistry, Genetics and Molecular Biology, focusing primarily on Molecular Biology. Their research spans various subfields including Genetics, Plant Science, Cancer Research, and Oncology.

The scientist has contributed extensively to topics such as DNA Repair Mechanisms, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, RNA Research and Splicing, RNA modifications and cancer, Fungal and yeast genetics research, and Epigenetics and DNA Methylation.

Notable recent publications include:

  • The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts (2021, Nature Genetics)
  • UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide (2020, Genes & Development)
  • TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage (2020, PLoS Genetics)
  • BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair (2021, The EMBO Journal)
  • ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair (2021, Nature Communications)

The frequent collaborators in their research include Belén Gómez-González, Sónia Barroso, María García-Rubio, Ana G. Rondón, and Aleix Bayona-Feliú.

Andrés Aguilera's work is published predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Methods in molecular biology
  • PLoS Genetics

Best Publications

  • R Loops: From Transcription Byproducts to Threats to Genome Stability

    Andrés Aguilera;Tatiana García-Muse

  • TREX is a conserved complex coupling transcription with messenger RNA export

    Katja Sträßer;Seiji Masuda;Paul Mason;Jens Pfannstiel

  • Replication stress and cancer

    Hélène Gaillard;Tatiana García-Muse;Andrés Aguilera

  • Genome instability: a mechanistic view of its causes and consequences

    Andrés Aguilera;Belén Gómez-González

  • Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

    Pablo Huertas;Andrés Aguilera

  • R loops: new modulators of genome dynamics and function

    José M. Santos-Pereira;Andrés Aguilera

  • Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

    Julie Sollier;Caroline Townsend Stork;María L. García-Rubio;Renee D. Paulsen

  • CDK targets Sae2 to control DNA-end resection and homologous recombination.

    Pablo Huertas;Felipe Cortés-Ledesma;Alessandro A. Sartori;Alessandro A. Sartori;Andrés Aguilera

  • BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

    Vaibhav Bhatia;Sonia I. Barroso;María L. García-Rubio;Emanuela Tumini

  • R Loops: From Physiological to Pathological Roles

    Tatiana García-Muse;Andrés Aguilera

  • Causes of Genome Instability

    Andrés Aguilera;Tatiana García-Muse

  • DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship.

    Benjamín Pardo;Belén Gómez-González;Andrés Aguilera

  • The connection between transcription and genomic instability

    Andrés Aguilera

  • Yeast Sen1 helicase protects the genome from transcription-associated instability.

    Hannah E. Mischo;Belén Gómez-González;Pawel Grzechnik;Ana G. Rondón;Ana G. Rondón

  • A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae

    Sebastian Chavez;Traude Beilharz;Ana G Rondon;Hediye Erdjument-Bromage

  • Transcription–replication conflicts: how they occur and how they are resolved

    Tatiana García-Muse;Andrés Aguilera

  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

    Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  • The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.

    Sonia Jimeno;Ana G Rondón;Rosa Luna;Andrés Aguilera

  • Impairment of replication fork progression mediates RNA polII transcription-associated recombination

    Félix Prado;Andrés Aguilera

  • The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

    María L. García-Rubio;Carmen Pérez-Calero;Sonia I. Barroso;Emanuela Tumini

Frequent Co-Authors

Hannah L. Klein
Hannah L. Klein New York University
James E. Haber
James E. Haber Brandeis University
Francesc Posas
Francesc Posas Pompeu Fabra University
Patrick Sung
Patrick Sung The University of Texas Health Science Center at San Antonio
Rodney Rothstein
Rodney Rothstein Columbia University
Wolf Dietrich Heyer
Wolf Dietrich Heyer University of California, Davis
Lorraine S. Symington
Lorraine S. Symington Columbia University
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Simon J. Boulton
Simon J. Boulton The Francis Crick Institute
Stephen C. West
Stephen C. West The Francis Crick Institute

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