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Genetics

D-Index
51
Citations
12060
World Ranking
3851
National Ranking
1664

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Hannah L. Klein is affiliated with New York University in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine. The scientist has produced work particularly focused on molecular biology while contributing to intersecting fields such as social psychology, psychiatry and mental health, infectious diseases, and cognitive neuroscience.

Among Klein's primary research topics are dementia and cognitive impairment, Clostridium difficile and Clostridium perfringens research, gut microbiota and health, neuroendocrine regulation and behavior, memory and neural mechanisms, primate behavior and ecology, and DNA repair mechanisms.

Frequent collaborators include Reisa A. Sperling, Dorene M. Rentz, Dylan Kirn, Keith A. Johnson, and Jenessa A. Winston. Their research has been published in notable scientific venues including bioRxiv (Cold Spring Harbor Laboratory), eLife, Alzheimer's & Dementia, Neurology, and the Journal of Veterinary Internal Medicine.

Klein's recent papers illustrate the diversity of their work:

  • Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults, 2021, Neurology
  • Developmental stages in microbiota, bile acids, and clostridial species in healthy puppies, 2020, Journal of Veterinary Internal Medicine
  • Subjective Cognitive Decline in a Registry Sample: Relation to Psychiatric History, Loneliness, and Personality, 2022, The Journal of Prevention of Alzheimer's Disease
  • Fecal identification markers impact the feline fecal microbiota, 2023, Frontiers in Veterinary Science
  • Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults, 2022, Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring

Hannah L. Klein was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • Mechanism of eukaryotic homologous recombination.

    Joseph San Filippo;Patrick Sung;Hannah Klein

  • Mechanism of homologous recombination: mediators and helicases take on regulatory functions

    Patrick Sung;Hannah Klein

  • Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin

    Irina E Vainberg;Sally A Lewis;Heidi Rommelaere;Christophe Ampe

  • DNA helicase Srs2 disrupts the Rad51 presynaptic filament

    Lumir Krejci;Stephen Van Komen;Ying Li;Jana Villemain

  • The consequences of Rad51 overexpression for normal and tumor cells.

    Hannah L. Klein

  • Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

    Rohit Prakash;Dominik Satory;Eloïse Dray;Almas Papusha

  • Intrachromosomal gene conversion in yeast

    Hannah L. Klein;Thomas D. Petes

  • Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations.

    Andres Aguilera;Hannah L. Klein

  • Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation.

    Galina Petukhova;Stephen Van Komen;Sefton Vergano;Hannah Klein

  • RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis.

    Hannah L. Klein

  • The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores

    Rodrigo Bermejo;Thelma Capra;Rachel Jossen;Arianna Colosio

  • A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling.

    Meiping Chang;Delores French-Cornay;Hua-ying Fan;Hannah Klein

  • Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break.

    Laurence Signon;Anna Malkova;Maria L. Naylor;Hannah Klein

  • Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae.

    Lei Rong;H. L. Klein

  • The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene.

    Lei Rong;F. Palladino;A. Aguilera;H. L. Klein

  • Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae.

    Hua-Ying Fan;Kenneth K. Cheng;Hannah L. Klein

  • Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1

    Galina Petukhova;Patrick Sung;Hannah Klein

  • Different types of recombination events are controlled by the RAD1 and RAD52 genes of Saccharomyces cerevisiae.

    Hannah L. Klein

  • Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed.

    Linda L. Button;David G. Russell;Hannah L. Klein;Enrique Medina-Acosta

  • HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.

    A Aguilera;H L Klein

Frequent Co-Authors

Patrick Sung
Patrick Sung The University of Texas Health Science Center at San Antonio
Andrés Aguilera
Andrés Aguilera University of Seville
Lumir Krejci
Lumir Krejci Masaryk University
Eric C. Greene
Eric C. Greene Columbia University
James E. Haber
James E. Haber Brandeis University
Lorraine S. Symington
Lorraine S. Symington Columbia University
Kenneth N. Kreuzer
Kenneth N. Kreuzer Duke University
Sue Jinks-Robertson
Sue Jinks-Robertson Duke University
Rodney Rothstein
Rodney Rothstein Columbia University
Michael Lisby
Michael Lisby University of Copenhagen

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