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Niklas Mattsson

Niklas Mattsson

D-Index & Metrics

Medicine

D-Index
98
Citations
39609
World Ranking
8864
National Ranking
180

Overview

Niklas Mattsson is affiliated with Lund University in Sweden and focuses primarily on medical research with an emphasis on neurodegenerative diseases. Their work spans multiple subfields including physiology, psychiatry and mental health, neurology, molecular biology, and radiology, nuclear medicine, and imaging.

The main areas of research for Mattsson revolve around Alzheimer's disease and related cognitive impairments, with significant contributions to understanding neurological disease mechanisms and treatments. Their work also includes studies on functional brain connectivity and the application of advanced neuroimaging and medical imaging techniques. Furthermore, research interests extend into Parkinson's disease mechanisms and treatments.

Mattsson has published extensively, with recent notable papers including:

  • Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders, 2020, JAMA
  • Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts, 2020, The Lancet Neurology
  • Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia, 2020, Nature Medicine
  • Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets, 2023, Nature Immunology
  • Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study, 2021, The Lancet Neurology

They have collaborated frequently with several researchers, including Oskar Hansson, Sebastian Palmqvist, Erik Stomrud, Olof Strandberg, and Ruben Smith. These collaborations have contributed to a substantial volume of publications.

Mattsson's research has appeared often in the following journals and publication venues:

  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • JAMA Neurology
  • Nature Medicine

Their contributions mainly focus on exploring biomarkers for Alzheimer's disease, such as plasma phosphorylated tau proteins, and investigating the accuracy of these markers in diagnosis and prognosis. This work extends into understanding the relationships between biomarkers and neuropathology as well as differentiating Alzheimer's from other neurodegenerative disorders.

Best Publications

  • Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

    Willemijn J. Jansen;Rik Ossenkoppele;Dirk L. Knol;Betty M. Tijms

  • CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.

    Niklas Mattsson;Henrik Zetterberg;Oskar Hansson;Niels Andreasen

  • Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders.

    Sebastian Palmqvist;Shorena Janelidze;Yakeel T. Quiroz;Yakeel T. Quiroz;Henrik Zetterberg

  • Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.

    Thomas K. Karikari;Tharick A. Pascoal;Tharick A. Pascoal;Nicholas J. Ashton;Shorena Janelidze

  • Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

    Shorena Janelidze;Niklas Mattsson;Sebastian Palmqvist;Ruben Smith

  • Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

    Sebastian Palmqvist;Michael Schöll;Michael Schöll;Olof Strandberg;Niklas Mattsson

  • Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

    Bridel C;van Wieringen Wn;Zetterberg H;Tijms Bm

  • Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.

    Niklas Mattsson;Nicholas C. Cullen;Nicholas C. Cullen;Ulf Andreasson;Ulf Andreasson;Henrik Zetterberg

  • Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

    Giovanni B Frisoni;Marina Boccardi;Frederik Barkhof;Kaj Blennow;Kaj Blennow

  • Amyloid biomarkers in Alzheimer's disease.

    Kaj Blennow;Kaj Blennow;Niklas Mattsson;Niklas Mattsson;Niklas Mattsson;Michael Schöll;Michael Schöll;Oskar Hansson

  • Association of cerebrospinal fluid neurofilament light concentration with Alzheimer disease progression

    Henrik Zetterberg;Henrik Zetterberg;Tobias Skillbäck;Niklas Mattsson;John Q. Trojanowski

  • Plasma tau in Alzheimer disease

    Niklas Mattsson;Henrik Zetterberg;Henrik Zetterberg;Henrik Zetterberg;Shorena Janelidze;Philip S. Insel

  • CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

    Shorena Janelidze;Henrik Zetterberg;Niklas Mattsson;Sebastian Palmqvist

  • Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders

    Rik Ossenkoppele;Rik Ossenkoppele;Gil D. Rabinovici;Ruben Smith;Hanna Cho

  • The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

    Niklas Mattsson;Ulf Andreasson;Staffan Persson;Hiroyuki Arai

  • Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status.

    Sebastian Palmqvist;Shorena Janelidze;Erik Stomrud;Henrik Zetterberg

  • Smoking and increased Alzheimer's disease risk: A review of potential mechanisms

    Timothy C. Durazzo;Timothy C. Durazzo;Niklas Mattsson;Niklas Mattsson;Niklas Mattsson;Michael W. Weiner

  • Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

    Sebastian Palmqvist;Henrik Zetterberg;Niklas Mattsson;Per Johansson

  • Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography.

    Sebastian Palmqvist;Niklas Mattsson;Oskar Hansson

  • CSF biomarker variability in the Alzheimer's Association quality control program

    Niklas Mattsson;Niklas Mattsson;Ulf Andreasson;Staffan Persson;Maria C. Carrillo

Frequent Co-Authors

Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Kaj Blennow
Kaj Blennow University of Gothenburg
Oskar Hansson
Oskar Hansson Lund University
Philip S. Insel
Philip S. Insel University of California, San Francisco
Sebastian Palmqvist
Sebastian Palmqvist Lund University
Erik Stomrud
Erik Stomrud Lund University
Ulf Andreasson
Ulf Andreasson University of Gothenburg
Michael W. Weiner
Michael W. Weiner University of California, San Francisco
Shorena Janelidze
Shorena Janelidze Lund University
Anders Wallin
Anders Wallin University of Gothenburg

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