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Neuroscience

D-Index
71
Citations
16544
World Ranking
2426
National Ranking
45

Overview

Erik Portelius is affiliated with Sahlgrenska University Hospital in Sweden and has contributed extensively to research in the field of medicine, with a particular focus on neurology and neurodegenerative diseases.

Portelius' work spans several subfields including physiology, molecular biology, neurology, psychiatry and mental health, as well as cellular and molecular neuroscience. Their research topics encompass:

  • Alzheimer's disease research and treatments
  • Dementia and cognitive impairment research
  • Amyloidosis: diagnosis, treatment, outcomes
  • S100 proteins and annexins
  • Down syndrome and intellectual disability research
  • Intracerebral and subarachnoid hemorrhage research
  • Neuroinflammation and neurodegeneration mechanisms

Recent publications by Portelius include:

  • Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain, 2020, Molecular Psychiatry
  • OUP accepted manuscript, 2020, Brain
  • Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's disease, 2021, Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring
  • Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics, 2021, Scientific Reports
  • Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases, 2020, Alzheimer's Research & Therapy

Portelius frequently publishes in journals such as:

  • Alzheimer's & Dementia
  • Alzheimer's Research & Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Psychiatry
  • Brain

Throughout their career, Portelius has collaborated repeatedly with several co-authors, including:

  • Kaj Blennow
  • Henrik Zetterberg
  • Gunnar Brinkmalm
  • Eleni Gkanatsiou
  • Johan Gobom

Best Publications

  • CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

    Bob Olsson;Ronald Lautner;Ulf Andreasson;Annika Öhrfelt

  • Association of cerebrospinal fluid neurofilament light concentration with Alzheimer disease progression

    Henrik Zetterberg;Henrik Zetterberg;Tobias Skillbäck;Niklas Mattsson;John Q. Trojanowski

  • Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

    Vladimir Coric;Christopher H. van Dyck;Stephen Salloway;Niels Andreasen

  • Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

    Erik Portelius;Nenad Bogdanovic;Mikael K. Gustavsson;Inga Volkmann

  • Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

    Hlin Kvartsberg;Flora H. Duits;Martin Ingelsson;Niels Andreasen

  • Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry.

    Erik Portelius;Ann Westman-Brinkmalm;Henrik Zetterberg;Kaj Blennow

  • Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid

    Adnan Halim;Gunnar Brinkmalm;Ulla Rüetschi;Ann Westman-Brinkmalm

  • Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease.

    Niklas Mattsson;Philip S Insel;Philip S Insel;Sebastian Palmqvist;Erik Portelius

  • Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer’s disease

    Erik Portelius;Henrik Zetterberg;Henrik Zetterberg;Tobias Skillbäck;Ulrika Törnqvist

  • Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid

    Maria Bjerke;Erik Portelius;Lennart Minthon;Anders Wallin

  • Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.

    Jere E. Meredith;Sethu Sankaranarayanan;Valerie Guss;Anthony J. Lanzetti

  • Increased CSF neurogranin concentration is specific to Alzheimer disease.

    Henrietta Wellington;Ross W. Paterson;Erik Portelius;Ulrika Törnqvist

  • Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

    Bob Olsson;Bob Olsson;Erik Portelius;Erik Portelius;Nicholas C. Cullen;Nicholas C. Cullen;Åsa Sandelius

  • A novel pathway for amyloid precursor protein processing.

    Erik Portelius;Eric Price;Gunnar Brinkmalm;Mark Stiteler

  • Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

    Jay Rasmussen;Jay Rasmussen;Jasmin Mahler;Natalie Beschorner;Stephan A. Kaeser;Stephan A. Kaeser

  • Pathways to Alzheimer's disease

    J. Hardy;N. Bogdanovic;B. Winblad;E. Portelius

  • Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry.

    Erik Portelius;Ai Jun Tran;Ulf Andreasson;Rita Persson

  • APP metabolism regulates tau proteostasis in human cerebral cortex neurons

    Steven James Moore;Lewis D Evans;Therése Andersson;Erik Portelius

  • C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

    Ann De Vos;Dirk Jacobs;Hanne Struyfs;Erik Fransen

  • Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology

    Åsa Sandelius;Erik Portelius;Åsa Källén;Henrik Zetterberg

  • Mass Spectrometry–Based Candidate Reference Measurement Procedure for Quantification of Amyloid-β in Cerebrospinal Fluid

    Andreas Leinenbach;Josef Pannee;Thomas Dülffer;Andreas Huber

  • An Alzheimer's disease-specific β-amyloid fragment signature in cerebrospinal fluid

    Erik Portelius;Henrik Zetterberg;Ulf Andreasson;Gunnar Brinkmalm

Frequent Co-Authors

Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Kaj Blennow
Kaj Blennow University of Gothenburg
Ulf Andreasson
Ulf Andreasson University of Gothenburg
Kina Höglund
Kina Höglund Sahlgrenska University Hospital
Maria Bjerke
Maria Bjerke University of Antwerp
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Hugo Vanderstichele
Hugo Vanderstichele Fujirebio (Belgium)
Jonathan M. Schott
Jonathan M. Schott University College London
Agneta Nordberg
Agneta Nordberg Karolinska University Hospital

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