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Sebastiaan Engelborghs

Sebastiaan Engelborghs

D-Index & Metrics

Medicine

D-Index
108
Citations
60126
World Ranking
5897
National Ranking
63

Overview

Sebastiaan Engelborghs is affiliated with the University of Antwerp in Belgium. Their research primarily focuses on Alzheimer's disease, dementia, and related neurological and molecular studies.

Their recent publications include the following papers:

  • Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum, 2022, JAMA Neurology
  • Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics, 2020, Brain
  • The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint, 2023, The Lancet Regional Health - Europe
  • Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study, 2020, Alzheimer s Research & Therapy
  • Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease, 2022, Molecular Neurodegeneration

Frequent co-authors in Engelborghs' work include:

  • Rik Vandenberghe
  • Christine Van Broeckhoven
  • Pieter Jelle Visser
  • Johannes Streffer
  • Henrik Zetterberg

Their research has been published extensively in venues such as:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology
  • Alzheimer s Research & Therapy
  • Journal of Alzheimer s Disease

Engelborghs' main fields of study cover Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in the following subfields:

  • Physiology
  • Psychiatry and Mental health
  • Molecular Biology
  • Neurology
  • Cognitive Neuroscience

The scientist's core research topics include:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Bioinformatics and Genomic Networks
  • Vestibular and auditory disorders
  • S100 Proteins and Annexins
  • Genetic Associations and Epidemiology
  • Functional Brain Connectivity Studies

Best Publications

  • Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

    Bruno Dubois;Bruno Dubois;Howard H Feldman;Claudia Jacova;Harald Hampel;Harald Hampel

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease

    J Lambert;S Heath;G Even;D Campion

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

    Willemijn J. Jansen;Rik Ossenkoppele;Dirk L. Knol;Betty M. Tijms

  • Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

    Marc Cruts;Ilse Gijselinck;Julie van der Zee;Sebastiaan Engelborghs

  • A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.

    Ilse Gijselinck;Tim Van Langenhove;Julie van der Zee;Kristel Sleegers

  • TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

    Gernot Kleinberger;Yoshinori Yamanishi;Marc Suárez-Calvet;Eva Czirr

  • APOE and Alzheimer disease: a major gene with semi-dominant inheritance

    E Genin;D Hannequin;D Wallon;K Sleegers

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • A Practical Guide to Immunoassay Method Validation

    Ulf Andreasson;Armand Perret-Liaudet;Linda J C van Waalwijk van Doorn;Kaj Blennow

  • Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People

    Geert De Meyer;Fred Shapiro;Hugo Vanderstichele;Eugeen Vanmechelen

  • sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

    Marc Suárez-Calvet;Marc Suárez-Calvet;Gernot Kleinberger;Miguel Ángel Araque Caballero;Matthias Brendel

  • A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

    Michael A. Nalls;Raquel Duran;Grisel Lopez;Marzena Kurzawa-Akanbi

  • Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

    J Chapuis;F Hansmannel;M Gistelinck;A Mounier

  • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative.

    Hugo Vanderstichele;Mirko Bibl;Sebastiaan Engelborghs;Nathalie Le Bastard

  • The lateralized linguistic cerebellum: A review and a new hypothesis

    Peter Marien;Sebastiaan Engelborghs;Franco Fabbro;Peter P. De Deyn

  • CSF biomarker variability in the Alzheimer's Association quality control program

    Niklas Mattsson;Niklas Mattsson;Ulf Andreasson;Staffan Persson;Maria C. Carrillo

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

Peter Paul De Deyn
Peter Paul De Deyn University of Antwerp
Kristel Sleegers
Kristel Sleegers University of Antwerp
Christine Van Broeckhoven
Christine Van Broeckhoven University of Antwerp
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Kaj Blennow
Kaj Blennow University of Gothenburg
Pieter Jelle Visser
Pieter Jelle Visser Amsterdam University Medical Centers
Patrick Cras
Patrick Cras University of Antwerp
Alberto Lleó
Alberto Lleó Hospital de la Santa Creu i Sant Pau
Marc Cruts
Marc Cruts University of Antwerp

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