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Kristel Sleegers

Kristel Sleegers

D-Index & Metrics

Genetics

D-Index
85
Citations
46519
World Ranking
1278
National Ranking
18

Overview

Kristel Sleegers is affiliated with the University of Antwerp in Belgium. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology, Physiology, Genetics, Psychiatry and Mental Health, and Neurology.

The main topics covered in their research include:

  • Alzheimer's disease research and treatments
  • Genetic Associations and Epidemiology
  • Dementia and Cognitive Impairment Research
  • Bioinformatics and Genomic Networks
  • Amyotrophic Lateral Sclerosis Research
  • Cholesterol and Lipid Metabolism
  • Mitochondrial Function and Pathology

Kristel Sleegers has collaborated frequently with several coauthors, including Fahri Küçükali, Rik Vandenberghe, Sebastiaan Engelborghs, Lars Bertram, and Henrik Zetterberg, each contributing to multiple joint publications.

The scientist has published extensively in a range of venues, notably:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Zenodo (CERN European Organization for Nuclear Research)
  • Alzheimer s Research & Therapy

Significant papers authored include:

  • Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes, 2022, Nature Neuroscience
  • Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease, 2022, Molecular Neurodegeneration
  • Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease, 2023, JAMA Network Open
  • Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease, 2022, JAMA Neurology
  • Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset, 2020, Translational Psychiatry

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease

    J Lambert;S Heath;G Even;D Campion

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • The genetic landscape of Alzheimer disease: clinical implications and perspectives

    Caroline Van Cauwenberghe;Christine Van Broeckhoven;Kristel Sleegers

  • A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.

    Ilse Gijselinck;Tim Van Langenhove;Julie van der Zee;Kristel Sleegers

  • TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

    Gernot Kleinberger;Yoshinori Yamanishi;Marc Suárez-Calvet;Eva Czirr

  • APOE and Alzheimer disease: a major gene with semi-dominant inheritance

    E Genin;D Hannequin;D Wallon;K Sleegers

  • Molecular genetics of early-onset Alzheimer's disease revisited.

    Rita Cacace;Kristel Sleegers;Christine Van Broeckhoven

  • sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

    Marc Suárez-Calvet;Marc Suárez-Calvet;Gernot Kleinberger;Miguel Ángel Araque Caballero;Matthias Brendel

  • Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

    J Chapuis;F Hansmannel;M Gistelinck;A Mounier

  • APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

    Kristel Sleegers;Nathalie Brouwers;Ilse Gijselinck;Jessie Theuns

  • Genetic insights in Alzheimer's disease

    Karolien Bettens;Kristel Sleegers;Christine Van Broeckhoven

  • Potent amyloidogenicity and pathogenicity of Aβ43

    Takashi Saito;Takahiro Suemoto;Nathalie Brouwers;Kristel Sleegers

  • Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond.

    Elise Cuyvers;Kristel Sleegers

  • A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats

    Julie van der Zee;Ilse Gijselinck;Lubina Dillen;Tim Van Langenhove

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

Sebastiaan Engelborghs
Sebastiaan Engelborghs University of Antwerp
Christine Van Broeckhoven
Christine Van Broeckhoven University of Antwerp
Peter Paul De Deyn
Peter Paul De Deyn University of Antwerp
Marc Cruts
Marc Cruts University of Antwerp
Caroline Graff
Caroline Graff Karolinska University Hospital
Alberto Lleó
Alberto Lleó Hospital de la Santa Creu i Sant Pau
Lars Bertram
Lars Bertram University of Lübeck
Pieter Jelle Visser
Pieter Jelle Visser Amsterdam University Medical Centers

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