D-Index & Metrics Best Publications
Margaret A. Pericak-Vance

Margaret A. Pericak-Vance

Research.com 2022 Best Scientist Award Badge Research.com 2022 Best Female Scientist Award Badge
Genetics
USA
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Best female scientists D-index 160 Citations 144,585 1,087 World Ranking 62 National Ranking 43
Best Scientists D-index 160 Citations 144,585 1,087 World Ranking 826 National Ranking 531
Medicine D-index 162 Citations 147,446 1,063 World Ranking 381 National Ranking 243
Genetics D-index 162 Citations 146,580 996 World Ranking 50 National Ranking 30

Research.com Recognitions

Awards & Achievements

2023 - Research.com Genetics in United States Leader Award

2022 - Research.com Best Female Scientist Award

2022 - Research.com Best Scientist Award

2011 - Fellow of the American Association for the Advancement of Science (AAAS)

2003 - Member of the National Academy of Medicine (NAM)

2001 - Grand Prix scientifique de la Fondation Louis D., Institut de France

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Genetics
  • Mutation

Margaret A. Pericak-Vance spends much of her time researching Genetics, Allele, Genome-wide association study, Locus and Genetic linkage. Her Genetics study frequently links to related topics such as Autism. Her Allele research includes themes of Multiple sclerosis, Immunology, Apolipoprotein E and Genotype.

Her Genome-wide association study study also includes

  • Alzheimer's disease which is related to area like Degenerative disease, Dementia and Age of onset,
  • Case-control study and related Macular degeneration. Her research in Locus tackles topics such as Chromosome which are related to areas like Linkage. Her Genetic linkage research includes elements of Chromosome 21, Amyotrophic lateral sclerosis, Genome, Genetic marker and Candidate gene.

Her most cited work include:

  • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families (7318 citations)
  • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. (4020 citations)
  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. (3630 citations)

What are the main themes of her work throughout her whole career to date?

Her main research concerns Genetics, Disease, Genetic linkage, Gene and Allele. Her Locus, Genome-wide association study, Single-nucleotide polymorphism, Genetic association and Haplotype investigations are all subjects of Genetics research. Margaret A. Pericak-Vance has researched Disease in several fields, including Oncology and Bioinformatics.

Her Genetic linkage research is multidisciplinary, incorporating elements of Genetic marker, Chromosome, Gene mapping, Genetic heterogeneity and Linkage. She works mostly in the field of Allele, limiting it down to topics relating to Apolipoprotein E and, in certain cases, Alzheimer's disease. Her Alzheimer's disease study integrates concerns from other disciplines, such as Age of onset and Degenerative disease.

She most often published in these fields:

  • Genetics (65.83%)
  • Disease (21.48%)
  • Genetic linkage (18.00%)

What were the highlights of her more recent work (between 2015-2021)?

  • Genetics (65.83%)
  • Disease (21.48%)
  • Genome-wide association study (16.09%)

In recent papers she was focusing on the following fields of study:

Genetics, Disease, Genome-wide association study, Alzheimer's disease and Gene are her primary areas of study. Her study in Genetics focuses on Locus, Allele, Exome sequencing, Genetic association and Single-nucleotide polymorphism. Her Locus study frequently intersects with other fields, such as Genetic linkage.

Her work in Allele covers topics such as Apolipoprotein E which are related to areas like Oncology and Demography. Her study looks at the relationship between Disease and fields such as Gerontology, as well as how they intersect with chemical problems. The Genome-wide association study study combines topics in areas such as Genomics, Glaucoma, Open angle glaucoma, Minor allele frequency and Haplotype.

Between 2015 and 2021, her most popular works were:

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants (720 citations)
  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism (538 citations)
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (496 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Mutation
  • Internal medicine

Her primary scientific interests are in Genetics, Genome-wide association study, Gene, Allele and Disease. Her research is interdisciplinary, bridging the disciplines of Alzheimer's disease and Genetics. Her studies in Genome-wide association study integrate themes in fields like Linkage disequilibrium, Allele frequency, Genomics and Glaucoma, Open angle glaucoma.

Her Gene research integrates issues from Multiple sclerosis and Cancer research. Her studies deal with areas such as Odds ratio, Apolipoprotein E and Immunology as well as Allele. Within one scientific family, Margaret A. Pericak-Vance focuses on topics pertaining to Genetic variation under Disease, and may sometimes address concerns connected to Candidate gene.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

E. H. Corder;A. M. Saunders;W. J. Strittmatter;D. E. Schmechel.
Science (1993)

10443 Citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Alison Goate;Marie-Christine Chartier-Harlin;Mike Mullan;Jeremy Brown.
Nature (1991)

5892 Citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter;Ann M. Saunders;Donald Schmechel;Margaret Pericak-Vance.
Proceedings of the National Academy of Sciences of the United States of America (1993)

5278 Citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

R. Sherrington;E. I. Rogaev;Y. Liang;E. A. Rogaeva.
Nature (1995)

5233 Citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Lindsay A. Farrer;L. Adrienne Cupples;Jonathan L. Haines;Bradley T Hyman.
JAMA (1997)

4636 Citations

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.

A. M. Saunders;W. J. Strittmatter;D. Schmechel;P. H. St. George-Hyslop.
Neurology (1993)

4621 Citations

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj.
Nature Genetics (2013)

3630 Citations

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

L A Farrer;L A Cupples;J L Haines;B Hyman.
JAMA (1997)

3145 Citations

Complement factor H variant increases the risk of age-related macular degeneration.

Jonathan L. Haines;Michael A. Hauser;Silke Schmidt;William K. Scott.
Science (2005)

2854 Citations

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer.
Nature (2011)

2667 Citations

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