H-Index & Metrics Top Publications
Margaret A. Pericak-Vance

Margaret A. Pericak-Vance

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Genetics and Molecular Biology H-index 148 Citations 116,427 591 World Ranking 68 National Ranking 46

Research.com Recognitions

Awards & Achievements

2011 - Fellow of the American Association for the Advancement of Science (AAAS)

2003 - Member of the National Academy of Medicine (NAM)

2001 - Grand Prix scientifique de la Fondation Louis D., Institut de France

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Genetics
  • Mutation

The scientist’s investigation covers issues in Genetics, Allele, Locus, Genetic linkage and Genome-wide association study. Her Allele research incorporates themes from Alzheimer's disease, Apolipoprotein E, Immunology and Genotype. Margaret A. Pericak-Vance has researched Apolipoprotein E in several fields, including SORL1 and Risk factor.

Her Locus research focuses on subjects like Chromosome, which are linked to Genetic determinism. Her work investigates the relationship between Genetic linkage and topics such as Amyotrophic lateral sclerosis that intersect with problems in Mutation. Margaret A. Pericak-Vance usually deals with Genome-wide association study and limits it to topics linked to Case-control study and Macular degeneration.

Her most cited work include:

  • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families (7112 citations)
  • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. (3929 citations)
  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. (3560 citations)

What are the main themes of her work throughout her whole career to date?

Her primary scientific interests are in Genetics, Disease, Genetic linkage, Gene and Locus. Her work on Alzheimer's disease expands to the thematically related Genetics. Her Alzheimer's disease research is multidisciplinary, incorporating perspectives in Age of onset, Gerontology and Degenerative disease.

The various areas that she examines in her Genetic linkage study include Genetic marker, Chromosome, Gene mapping, Genetic heterogeneity and Linkage. Her Allele study incorporates themes from Apolipoprotein E, Immunology, Genotype and Risk factor. Her studies in Single-nucleotide polymorphism integrate themes in fields like Haplotype and Candidate gene.

She most often published in these fields:

  • Genetics (67.56%)
  • Disease (21.81%)
  • Genetic linkage (18.85%)

What were the highlights of her more recent work (between 2015-2021)?

  • Genetics (67.56%)
  • Disease (21.81%)
  • Alzheimer's disease (17.28%)

In recent papers she was focusing on the following fields of study:

Margaret A. Pericak-Vance mainly focuses on Genetics, Disease, Alzheimer's disease, Genome-wide association study and Gene. Her work on Genetics deals in particular with Locus, Allele, Genetic association, Exome sequencing and Single-nucleotide polymorphism. Her Locus research is multidisciplinary, relying on both Minor allele frequency and Genetic linkage.

Her study focuses on the intersection of Allele and fields such as Apolipoprotein E with connections in the field of Genotype, Oncology and Demography. Her biological study spans a wide range of topics, including SORL1, Gerontology and Cohort. Her research integrates issues of Genomics, TREM2, Glaucoma, Open angle glaucoma and Haplotype in her study of Genome-wide association study.

Between 2015 and 2021, her most popular works were:

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants (638 citations)
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (429 citations)
  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism (373 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Mutation

Her main research concerns Genetics, Genome-wide association study, Gene, Alzheimer's disease and Disease. Her is involved in several facets of Genetics study, as is seen by her studies on Locus, Genetic association, Single-nucleotide polymorphism, Allele and Exome sequencing. Margaret A. Pericak-Vance has included themes like Odds ratio and Apolipoprotein E in her Allele study.

Her Genome-wide association study study combines topics in areas such as Allele frequency, Genomics, Meta-analysis and Glaucoma, Open angle glaucoma. Margaret A. Pericak-Vance interconnects Lipid metabolism and Immunology in the investigation of issues within Gene. The study incorporates disciplines such as SORL1, Age of onset and Genetic epidemiology in addition to Alzheimer's disease.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

E. H. Corder;A. M. Saunders;W. J. Strittmatter;D. E. Schmechel.
Science (1993)

9267 Citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Alison Goate;Marie-Christine Chartier-Harlin;Mike Mullan;Jeremy Brown.
Nature (1991)

5417 Citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter;Ann M. Saunders;Donald Schmechel;Margaret Pericak-Vance.
Proceedings of the National Academy of Sciences of the United States of America (1993)

4867 Citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

R. Sherrington;E. I. Rogaev;Y. Liang;E. A. Rogaeva.
Nature (1995)

4794 Citations

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.

A. M. Saunders;W. J. Strittmatter;D. Schmechel;P. H. St. George-Hyslop.
Neurology (1993)

4247 Citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Lindsay A. Farrer;L. Adrienne Cupples;Jonathan L. Haines;Bradley T Hyman.
JAMA (1997)

3888 Citations

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

L A Farrer;L A Cupples;J L Haines;B Hyman.
JAMA (1997)

3145 Citations

Complement factor H variant increases the risk of age-related macular degeneration.

Jonathan L. Haines;Michael A. Hauser;Silke Schmidt;William K. Scott.
Science (2005)

2622 Citations

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj.
Nature Genetics (2013)

2605 Citations

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer.
Nature (2011)

2262 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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