D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 90 Citations 45,212 250 World Ranking 627 National Ranking 80

Research.com Recognitions

Awards & Achievements

2004 - Fellow of the Royal Society, United Kingdom

2002 - Fellow of the Royal Society of Canada Academy of Science

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Genetics
  • Enzyme

Peter St George-Hyslop mainly focuses on Genetics, Alzheimer's disease, Genome-wide association study, Presenilin and Cell biology. His work on Genetics is being expanded to include thematically relevant topics such as Apolipoprotein E. His Alzheimer's disease study results in a more complete grasp of Disease.

His work is dedicated to discovering how Genome-wide association study, Common disease-common variant are connected with TREM2 and other disciplines. His study in Presenilin is interdisciplinary in nature, drawing from both Mutation, Missense mutation, Endoplasmic reticulum, Biochemistry and Amyloid precursor protein. His study looks at the relationship between Cell biology and fields such as Amyloid, as well as how they intersect with chemical problems.

His most cited work include:

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease (2614 citations)
  • TREM2 Variants in Alzheimer's Disease (1646 citations)
  • TREM2 Variants in Alzheimer's Disease (1646 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Genetics, Presenilin, Alzheimer's disease, Disease and Cell biology. His Presenilin research is multidisciplinary, relying on both Biochemistry and Amyloid precursor protein secretase, Amyloid precursor protein. The study incorporates disciplines such as Molecular biology and SORL1 in addition to Amyloid precursor protein.

His studies deal with areas such as Apolipoprotein E, Dementia and Amyloid as well as Alzheimer's disease. His research integrates issues of Neuroscience, Immunology and Bioinformatics in his study of Disease. His Genome-wide association study research incorporates themes from PICALM and Case-control study.

He most often published in these fields:

  • Genetics (54.21%)
  • Presenilin (36.45%)
  • Alzheimer's disease (31.96%)

What were the highlights of his more recent work (between 2015-2021)?

  • Disease (29.16%)
  • Genetics (54.21%)
  • Biophysics (10.28%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Disease, Genetics, Biophysics, Genome-wide association study and Neuroscience. His work carried out in the field of Disease brings together such families of science as Exome sequencing, SORL1 and Neurology. His Genetics study often links to related topics such as Agenesis of the corpus callosum.

His Genome-wide association study study is related to the wider topic of Single-nucleotide polymorphism. His Neuroscience research integrates issues from Alzheimer's disease, Frontotemporal dementia and Tauopathy. His research in Alzheimer's disease intersects with topics in Mutant and Cognitive decline.

Between 2015 and 2021, his most popular works were:

  • Analysis of shared heritability in common disorders of the brain (726 citations)
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (429 citations)
  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions (294 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Genetics
  • Enzyme

Peter St George-Hyslop focuses on Genome-wide association study, Biophysics, Disease, Alzheimer's disease and Genetics. The Genome-wide association study study combines topics in areas such as SNP, Apolipoprotein E, Bipolar disorder and Genetic association. His Biophysics research includes elements of Calcium, Amyotrophic lateral sclerosis, Sequence motif, Stress granule and RNA-binding protein.

His study in the field of Dementia with Lewy bodies and Dementia also crosses realms of Psychological resilience. The various areas that Peter St George-Hyslop examines in his Alzheimer's disease study include Receptor, Neuroscience, Gene and Cognitive decline. His Genetics research is multidisciplinary, incorporating elements of Corpus callosum and Pathology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj.
Nature Genetics (2013)

2605 Citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews.
Nature (2000)

1901 Citations

TREM2 Variants in Alzheimer's Disease

Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo.
The New England Journal of Medicine (2013)

1821 Citations

Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang.
Nature Genetics (2011)

1580 Citations

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu.
Nature Genetics (2007)

1208 Citations

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Gang Yu;Masaki Nishimura;Shigeki Arawaka;Shigeki Arawaka;Diane Levitan.
Nature (2000)

1204 Citations

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi.
PLOS ONE (2014)

1078 Citations

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

M. Azhar Chishti;Dun-Shen Yang;Christopher Janus;Amie L. Phinney.
Journal of Biological Chemistry (2001)

1043 Citations

Functional variants of OCTN cation transporter genes are associated with Crohn disease.

Vanya D Peltekova;Richard F Wintle;Laurence A Rubin;Laurence A Rubin;Christopher I Amos.
Nature Genetics (2004)

948 Citations

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

Taiichi Katayama;Kazunori Imaizumi;Naoya Sato;Ko Miyoshi.
Nature Cell Biology (1999)

726 Citations

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