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Peter St George-Hyslop

Peter St George-Hyslop

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Genetics
UK
2024
Award Badge
Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
116
Citations
74486
World Ranking
437
National Ranking
227

Medicine

D-Index
119
Citations
79050
World Ranking
3815
National Ranking
2091

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2004 - Fellow of the Royal Society, United Kingdom
  • 2002 - Fellow of the Royal Society of Canada Academy of Science

Overview

Peter St George-Hyslop is affiliated with Columbia University in the United States and has an extensive research portfolio focused on biochemistry, genetics, molecular biology, and medicine. Their work contributes to several subfields including molecular biology, neurology, physiology, cell biology, and genetics.

Their research frequently addresses topics such as RNA research and splicing, Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neurological diseases and metabolism, protein structure and dynamics, RNA modifications and cancer, and lipid membrane structure and behavior.

Recent publications by Peter St George-Hyslop include:

  • "Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions", 2021, Nature Communications
  • "Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture", 2021, Nature Genetics
  • "Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition", 2020, Nature Nanotechnology
  • "The liquid-to-solid transition of FUS is promoted by the condensate surface", 2023, Proceedings of the National Academy of Sciences
  • "Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death", 2020, Communications Biology

Frequent co-authors collaborating with Peter St George-Hyslop include:

  • Seema Qamar
  • Tuomas P. J. Knowles
  • Jonathon Nixon-Abell
  • Tomas Šneideris
  • Daoyuan Qian

They have published predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Nature Communications
  • Biophysical Journal
  • Brain

The scientist has been recognized by election to fellowships, including:

  • Fellow of the Royal Society, United Kingdom (2004)
  • Fellow of the Royal Society of Canada (2002), Academy of Science

Best Publications

  • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

    R. Sherrington;E. I. Rogaev;Y. Liang;E. A. Rogaeva

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

    E. I. Rogaev;R. Sherrington;E. A. Rogaeva;G. Levesque

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

    R. E. Tanzi;J. F. Gusella;P. C. Watkins;G. A. P. Bruns

  • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

    Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • The genetic defect causing familial Alzheimer's disease maps on chromosome 21

    Peter H. St George-Hyslop;Rudolph E. Tanzi;Ronald J. Polinsky;Jonathan L. Haines

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

    Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

    Gang Yu;Masaki Nishimura;Shigeki Arawaka;Shigeki Arawaka;Diane Levitan

  • Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

    M. Azhar Chishti;Dun-Shen Yang;Christopher Janus;Amie L. Phinney

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Functional variants of OCTN cation transporter genes are associated with Crohn disease.

    Vanya D Peltekova;Richard F Wintle;Laurence A Rubin;Laurence A Rubin;Christopher I Amos

  • ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

    Tetsuro Murakami;Seema Qamar;Julie Qiaojin Lin;Gabriele S Kaminski Schierle

  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  • Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

    Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman

  • γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

    Sangram S. Sisodia;Peter H. St George-Hyslop

  • α-Synuclein Membrane Interactions and Lipid Specificity

    Euijung Jo;JoAnne McLaurin;Christopher M. Yip;Peter St. George-Hyslop;Peter St. George-Hyslop

Frequent Co-Authors

Ekaterina Rogaeva
Ekaterina Rogaeva University of Toronto
Paul E. Fraser
Paul E. Fraser University of Toronto
Richard Mayeux
Richard Mayeux Columbia University
Lindsay A. Farrer
Lindsay A. Farrer Boston University
David Westaway
David Westaway University of Alberta
Badri N. Vardarajan
Badri N. Vardarajan Columbia University
John Hardy
John Hardy University College London
Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami
Sandro Sorbi
Sandro Sorbi University of Florence
Pau Pastor
Pau Pastor University of Navarra

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