Paul E. Fraser

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

  R. Sherrington;E. I. Rogaev;Y. Liang;E. A. Rogaeva

  5388
  Citations

• Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

  E. I. Rogaev;R. Sherrington;E. A. Rogaeva;G. Levesque

  2658
  Citations

• Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

  Margaret Sunde;Louise C Serpell;Mark Bartlam;Paul E Fraser

  2159
  Citations

• Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

  Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  2019
  Citations

• Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

  Martin Citron;David Westaway;Weiming Xia;George Carlson

  1800
  Citations

• The cellular prion protein binds copper in vivo

  D R Brown;K Qin;J W Herms;A Madlung

  1654
  Citations

• The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

  Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  1422
  Citations

• Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

  David R. Booth;Margaret Sunde;Vittorio Bellotti;Vittorio Bellotti;Carol V. Robinson

  1327
  Citations

• Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

  Gang Yu;Masaki Nishimura;Shigeki Arawaka;Shigeki Arawaka;Diane Levitan

  1266
  Citations

• Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

  M. Azhar Chishti;Dun-Shen Yang;Christopher Janus;Amie L. Phinney

  1186
  Citations

• ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

  Tetsuro Murakami;Seema Qamar;Julie Qiaojin Lin;Gabriele S Kaminski Schierle

  924
  Citations

• FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

  Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  906
  Citations

• α-Synuclein Membrane Interactions and Lipid Specificity

  Euijung Jo;JoAnne McLaurin;Christopher M. Yip;Peter St. George-Hyslop;Peter St. George-Hyslop

  744
  Citations

• Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

  Robert Kisilevsky;Laura J. Lemieux;Paul E. Fraser;Xianqi Kong

  592
  Citations

• A kinetic model for amyloid formation in the prion diseases: importance of seeding.

  Jon H. Come;Paul E. Fraser;Peter T. Lansbury

  581
  Citations

• Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

  J McLaurin;R Cecal;M E Kierstead;X Tian

  561
  Citations

• The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

  Gang Yu;Fusheng Chen;G. Levesque;M. Nishimura

  555
  Citations

• The protofilament substructure of amyloid fibrils.

  Louise C Serpell;Margaret Sunde;Merrill D Benson;Glenys A Tennent

  496
  Citations

• pH-dependent structural transitions of Alzheimer amyloid peptides.

  P. E. Fraser;J. T. Nguyen;Witold K. Surewicz;D. A. Kirschner

  480
  Citations

• An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

  Alan D. Snow;Raymond Sekiguchi;David Nochlin;Paul Fraser

  457
  Citations