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Paul E. Fraser

Paul E. Fraser

University of Toronto
Canada

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
106
Citations
52986
World Ranking
1133
National Ranking
27

Paul E. Fraser publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Paul E. Fraser sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 335 publications — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Paul E. Fraser D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Paul E. Fraser sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 106 D-Index — 94th percentile

94% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Paul E. Fraser is affiliated with the University of Toronto in Canada and focuses mainly on research within medicine, biochemistry, genetics, and molecular biology. Their scientific contributions span multiple subfields, including physiology, molecular biology, neurology, cellular and molecular neuroscience, and genetics.

The scientist's work covers several key topics in biomedical research such as Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, ubiquitin and proteasome pathways, neuroscience and neuropharmacology research, genetics and neurodevelopmental disorders, Parkinson's disease mechanisms and treatments, and tryptophan and brain disorders.

Paul E. Fraser has published extensively, with notable recent papers including:

  • Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease (2021) - Translational Psychiatry
  • Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation (2021) - Journal of Biological Chemistry
  • Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice (2020) - Alzheimer s & Dementia
  • Tau is not necessary for amyloid-β-induced synaptic and memory impairments (2020) - Journal of Clinical Investigation
  • Behavioral Abnormalities in Knockout and Humanized Tau Mice (2020) - Frontiers in Endocrinology

Their research has been disseminated in various publication venues, with frequent appearances in:

  • Journal of Biological Chemistry (9 publications)
  • Alzheimer s & Dementia (6 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Acta Neuropathologica Communications (2 publications)
  • Translational Psychiatry (1 publication)

Paul E. Fraser often collaborates with other researchers. Frequent co-authors include:

  • Jeffrey T. Henderson
  • Ottavio Arancio
  • Elliya Park
  • Chunsheng He
  • Xiao Yu Wu

Best Publications

  • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

    R. Sherrington;E. I. Rogaev;Y. Liang;E. A. Rogaeva

  • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

    E. I. Rogaev;R. Sherrington;E. A. Rogaeva;G. Levesque

  • Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

    Margaret Sunde;Louise C Serpell;Mark Bartlam;Paul E Fraser

  • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

    Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

    Martin Citron;David Westaway;Weiming Xia;George Carlson

  • The cellular prion protein binds copper in vivo

    D R Brown;K Qin;J W Herms;A Madlung

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

    Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  • Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

    David R. Booth;Margaret Sunde;Vittorio Bellotti;Vittorio Bellotti;Carol V. Robinson

  • Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

    Gang Yu;Masaki Nishimura;Shigeki Arawaka;Shigeki Arawaka;Diane Levitan

  • Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

    M. Azhar Chishti;Dun-Shen Yang;Christopher Janus;Amie L. Phinney

  • ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

    Tetsuro Murakami;Seema Qamar;Julie Qiaojin Lin;Gabriele S Kaminski Schierle

  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  • α-Synuclein Membrane Interactions and Lipid Specificity

    Euijung Jo;JoAnne McLaurin;Christopher M. Yip;Peter St. George-Hyslop;Peter St. George-Hyslop

  • Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

    Robert Kisilevsky;Laura J. Lemieux;Paul E. Fraser;Xianqi Kong

  • A kinetic model for amyloid formation in the prion diseases: importance of seeding.

    Jon H. Come;Paul E. Fraser;Peter T. Lansbury

  • Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

    J McLaurin;R Cecal;M E Kierstead;X Tian

  • The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

    Gang Yu;Fusheng Chen;G. Levesque;M. Nishimura

  • The protofilament substructure of amyloid fibrils.

    Louise C Serpell;Margaret Sunde;Merrill D Benson;Glenys A Tennent

  • pH-dependent structural transitions of Alzheimer amyloid peptides.

    P. E. Fraser;J. T. Nguyen;Witold K. Surewicz;D. A. Kirschner

  • An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

    Alan D. Snow;Raymond Sekiguchi;David Nochlin;Paul Fraser

Frequent Co-Authors

Peter St George-Hyslop
Peter St George-Hyslop Columbia University
David Westaway
David Westaway University of Alberta
Johanna M. Rommens
Johanna M. Rommens University of Toronto
Ekaterina Rogaeva
Ekaterina Rogaeva University of Toronto
P. H. St George-Hyslop
P. H. St George-Hyslop University of Toronto
JoAnne McLaurin
JoAnne McLaurin Sunnybrook Health Science Centre
Ralph N. Martins
Ralph N. Martins Edith Cowan University
Paul M. Mathews
Paul M. Mathews New York University
Daniel A. Kirschner
Daniel A. Kirschner Boston College
Avijit Chakrabartty
Avijit Chakrabartty University of Toronto

External Links

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Best Scientists Citing Paul E. Fraser

Christopher M. Dobson

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Publications: 152

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Peter St George-Hyslop

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Publications: 136

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Publications: 123

Bart De Strooper

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Dennis J. Selkoe

Brigham and Women's Hospital

Publications: 120

Rudolph E. Tanzi

Rudolph E. Tanzi

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Publications: 118

Christian Haass

Christian Haass

Ludwig-Maximilians-Universität München

Publications: 114

Ralph N. Martins

Ralph N. Martins

Edith Cowan University

Publications: 98

Colin L. Masters

Colin L. Masters

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Publications: 97

David R. Brown

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Publications: 97

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Publications: 94

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Sangram S. Sisodia

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Publications: 90

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Alison Goate

Icahn School of Medicine at Mount Sinai

Publications: 90

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University of Alberta

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