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Biology and Biochemistry

D-Index
61
Citations
15176
World Ranking
11246
National Ranking
389

Overview

JoAnne McLaurin is affiliated with Sunnybrook Health Science Centre in Canada and focuses primarily on research related to Alzheimer's disease and neuroscience. Their work spans several interconnected fields, including Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Neurology, and Physiology as key subfields.

The main topics of their research include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Mitochondrial Function and Pathology
  • Stress Responses and Cortisol
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Memory and Neural Mechanisms

Frequent publication venues for McLaurin's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
  • Theranostics
  • Translational Neurodegeneration

Some of McLaurin's recent papers are:

  • Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease, 2020, Proceedings of the National Academy of Sciences
  • Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), 2020, Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring
  • Potential Role of Venular Amyloid in Alzheimer's Disease Pathogenesis, 2020, International Journal of Molecular Sciences
  • Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease, 2022, Translational Neurodegeneration
  • The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis, 2020, NeuroImage

McLaurin collaborates regularly with a group of co-authors, including Mary Hill, Bojana Stefanovic, Aaron Y. Lai, Tina L. Beckett, and Margaret M. Koletar. These collaborators have worked with McLaurin on multiple publications, reflecting ongoing research partnerships.

Best Publications

  • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

    Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  • α-Synuclein Membrane Interactions and Lipid Specificity

    Euijung Jo;JoAnne McLaurin;Christopher M. Yip;Peter St. George-Hyslop;Peter St. George-Hyslop

  • Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

    J McLaurin;R Cecal;M E Kierstead;X Tian

  • Membrane Disruption by Alzheimer β-Amyloid Peptides Mediated through Specific Binding to Either Phospholipids or Gangliosides: IMPLICATIONS FOR NEUROTOXICITY *

    JoAnne McLaurin;Avi Chakrabartty

  • Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

    Cheryl A. Hawkes;JoAnne McLaurin

  • Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

    Jo Anne McLaurin;Meredith E. Kierstead;Mary E. Brown;Cheryl A. Hawkes

  • Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

    Jessica F. Jordão;Carlos A. Ayala-Grosso;Carlos A. Ayala-Grosso;Kelly Markham;Yuexi Huang

  • Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity

    JoAnne McLaurin;Rivka Golomb;Anna Jurewicz;Jack P. Antel

  • Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth.

    JoAnne McLaurin;Trudy Franklin;Xiaoqiong Zhang;Jianping Deng

  • Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

    Jessica F. Jordão;Emmanuel Thévenot;Kelly Markham-Coultes;Tiffany Scarcelli;Tiffany Scarcelli

  • Review: modulating factors in amyloid-beta fibril formation.

    J. McLaurin;D.-S. Yang;C.M. Yip;P.E. Fraser

  • Amyloid-β Peptide Assembly: A Critical Step in Fibrillogenesis and Membrane Disruption

    Christopher M. Yip;JoAnne McLaurin

  • Immunotherapy for Alzheimer's disease

    David S. Gelinas;Kevin DaSilva;Daniela Fenili;Peter St. George-Hyslop

  • Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

    JoAnne McLaurin;Avijit Chakrabartty

  • CD163 Identifies Perivascular Macrophages in Normal and Viral Encephalitic Brains and Potential Precursors to Perivascular Macrophages in Blood

    Woong-Ki Kim;Xavier Alvarez;Jeanne Fisher;Benjamin Bronfin

  • Cholesterol, a modulator of membrane-associated aβ-fibrillogenesis and neurotoxicity

    C.M. Yip;E.A. Elton;A.A. Darabie;M.R. Morrison

  • Structural Transitions Associated with the Interaction of Alzheimer β-Amyloid Peptides with Gangliosides

    JoAnne McLaurin;Trudy Franklin;Paul E. Fraser;Avijit Chakrabartty

  • Aβ42-Peptide Assembly on Lipid Bilayers

    Christopher M. Yip;Audrey A. Darabie;JoAnne McLaurin

  • Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest.

    J McLaurin;T Franklin;A Chakrabartty;P.E Fraser

  • The role of the immune system in Alzheimer disease: Etiology and treatment.

    Stefan Jevtic;Ameet S. Sengar;Michael W. Salter;JoAnne McLaurin;JoAnne McLaurin

Frequent Co-Authors

Isabelle Aubert
Isabelle Aubert Sunnybrook Health Science Centre
Paul E. Fraser
Paul E. Fraser University of Toronto
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Avijit Chakrabartty
Avijit Chakrabartty University of Toronto
David Westaway
David Westaway University of Alberta
John G. Sled
John G. Sled University of Toronto
Kullervo Hynynen
Kullervo Hynynen Sunnybrook Health Science Centre
Sylvain Houle
Sylvain Houle University of Toronto
Sandra E. Black
Sandra E. Black University of Toronto
P. H. St George-Hyslop
P. H. St George-Hyslop University of Toronto

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