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Medicine

D-Index
135
Citations
63867
World Ranking
2076
National Ranking
75

Overview

Kullervo Hynynen is affiliated with Sunnybrook Health Science Centre in Canada. Their research primarily spans the main fields of Engineering and Medicine, with a specific focus on Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, and Neurology.

The scientist's work concentrates on topics related to ultrasound and hyperthermia applications, photoacoustic and ultrasonic imaging, ultrasound imaging and elastography, as well as ultrasound and cavitation phenomena. Additional areas of research include advanced MRI techniques and applications, neurological disorders and treatments, and traumatic brain injury and neurovascular disturbances.

Frequent publication venues for Hynynen include The Journal of the Acoustical Society of America, Pharmaceutics, Theranostics, Journal of Controlled Release, and IEEE Transactions on Biomedical Engineering.

Hynynen has contributed to multiple notable research papers, including:

  • Super-resolution Ultrasound Imaging, 2020, Ultrasound in Medicine & Biology
  • Applications of focused ultrasound in the brain: from thermoablation to drug delivery, 2020, Nature Reviews Neurology
  • Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery, 2020, Ultrasound in Medicine & Biology
  • MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases, 2021, Science Translational Medicine
  • Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior, 2020, eLife

They have frequently collaborated with several co-authors, including Nir Lipsman, Ryan M. Jones, Ying Meng, Yuexi Huang, and Clement Hamani.

Best Publications

  • Noninvasive MR Imaging-Guided Focal Opening of the Blood-Brain Barrier in Rabbits

    Kullervo Hynynen;Nathan McDannold;Natalia Vykhodtseva;Ferenc A. Jolesz

  • A randomized trial of focused ultrasound thalamotomy for essential tremor

    W. Jeffrey Elias;Nir Lipsman;William G. Ondo;Pejman Ghanouni

  • Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

    Nir Lipsman;Nir Lipsman;Ying Meng;Allison J. Bethune;Allison J. Bethune;Yuexi Huang

  • Overview of Therapeutic Ultrasound Applications and Safety Considerations

    Douglas L. Miller;Nadine B. Smith;Michael R. Bailey;Gregory J. Czarnota

  • MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study.

    Kullervo Hynynen;Oliver Pomeroy;Darrell N. Smith;Peter E. Huber

  • Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

    Kullervo Hynynen;Nathan McDannold;Nickolai A. Sheikov;Ferenc A. Jolesz

  • MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.

    Clare M C Tempany;Elizabeth A Stewart;Nathan McDannold;Bradley J Quade

  • Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.

    Manabu Kinoshita;Nathan McDannold;Ferenc A. Jolesz;Kullervo Hynynen

  • Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.

    Nickolai Sheikov;Nathan McDannold;Natalia Vykhodtseva;Ferenc Jolesz

  • Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients.

    Nathan McDannold;Greg T. Clement;Peter Black;Ferenc Jolesz

  • MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

    Nir Lipsman;Michael L Schwartz;Yuexi Huang;Liesly Lee

  • Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound.

    Lisa H. Treat;Nathan McDannold;Natalia Vykhodtseva;Yongzhi Zhang

  • Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium

    Nickolai Sheikov;Nathan McDannold;Shipra Sharma;Kullervo Hynynen

  • A non-invasive method for focusing ultrasound through the human skull

    G T Clement;K Hynynen

  • Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity.

    N McDannold;N Vykhodtseva;K Hynynen

  • The threshold for thermally significant cavitation in dog's thigh muscle in vivo.

    K. Hynynen

  • Demonstration of Potential Noninvasive Ultrasound Brain Therapy Through an Intact Skull

    Kullervo Hynynen;Ferenc A Jolesz

  • Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

    Todd Mainprize;Nir Lipsman;Nir Lipsman;Yuexi Huang;Ying Meng;Ying Meng

  • Chemotherapy delivery issues in central nervous system malignancy: a reality check.

    Leslie L. Muldoon;Carole Soussain;Kristoph Jahnke;Conrad Johanson

  • MRI-guided noninvasive ultrasound surgery.

    K. Hynynen;A. Darkazanli;E. Unger;J. F. Schenck

Frequent Co-Authors

Nathan McDannold
Nathan McDannold Brigham and Women's Hospital
Ferenc A. Jolesz
Ferenc A. Jolesz Brigham and Women's Hospital
Isabelle Aubert
Isabelle Aubert Sunnybrook Health Science Centre
Nir Lipsman
Nir Lipsman Sunnybrook Health Science Centre
Elisa E. Konofagou
Elisa E. Konofagou Columbia University
Clare M. Tempany
Clare M. Tempany Brigham and Women's Hospital
Robert V. Mulkern
Robert V. Mulkern Boston Children's Hospital
Andres M. Lozano
Andres M. Lozano University of Toronto
JoAnne McLaurin
JoAnne McLaurin Sunnybrook Health Science Centre
Arjun Sahgal
Arjun Sahgal Sunnybrook Health Science Centre

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