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Neuroscience

D-Index
42
Citations
8620
World Ranking
7579
National Ranking
445

Overview

Isabelle Aubert is a researcher affiliated with Sunnybrook Health Science Centre in Canada. Their work primarily spans the fields of Engineering and Medicine, with a focus on Biomedical Engineering, Neurology, and Molecular Biology. Additional areas of expertise include Radiology, Nuclear Medicine and Imaging, and Genetics.

Their research contributions have targeted diverse topics including Ultrasound and Hyperthermia Applications, Photoacoustic and Ultrasonic Imaging, Virus-based gene therapy research, Retinal Development and Disorders, Traumatic Brain Injury and Neurovascular Disturbances, Vagus Nerve Stimulation Research, and Ultrasound and Cavitation Phenomena.

Recent scientific papers authored or co-authored by Aubert include the following:

  • MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors (2021, Neuro-Oncology)
  • Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease (2020, Proceedings of the National Academy of Sciences)
  • Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease (2020, Science Advances)
  • Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound (2023, Brain)
  • Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas (2022, Journal of Controlled Release)

Aubert has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Molecular Therapy - Methods & Clinical Development, Le philosophoire, Brain, and Frontiers in Cellular Neuroscience.

Their collaborative network includes co-authors:

  • Kullervo Hynynen (18 collaborations)
  • Rikke Hahn Kofoed (12 collaborations)
  • Carol Schuurmans (8 collaborations)
  • Yacine Touahri (7 collaborations)
  • Luke Ajay David (7 collaborations)

Aubert's research is characterized by an interdisciplinary approach, integrating engineering principles with clinical medicine to address challenges in neurological disorders and therapeutic delivery systems. The focus on ultrasound-based technologies reflects a commitment to exploring innovative methods for diagnosis, drug delivery, and neural function modulation.

Best Publications

  • Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

    Nir Lipsman;Nir Lipsman;Ying Meng;Allison J. Bethune;Allison J. Bethune;Yuexi Huang

  • Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

    Judes Poirier;Marie Claude Delisle;Rémi Quirion;Isabelle Aubert

  • First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

    Agessandro Abrahao;Agessandro Abrahao;Ying Meng;Ying Meng;Maheleth Llinas;Maheleth Llinas;Yuexi Huang

  • Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

    Jessica F. Jordão;Carlos A. Ayala-Grosso;Carlos A. Ayala-Grosso;Kelly Markham;Yuexi Huang

  • Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases.

    I. Aubert;D. M. Araujo;D. Cécyre;Y. Robitaille

  • Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

    Jessica F. Jordão;Emmanuel Thévenot;Kelly Markham-Coultes;Tiffany Scarcelli;Tiffany Scarcelli

  • Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

    Alison Burgess;Sonam Dubey;Sharon Yeung;Olivia Hough

  • Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.

    Alison Burgess;Carlos A. Ayala-Grosso;Carlos A. Ayala-Grosso;Milan Ganguly;Jessica F. Jordão;Jessica F. Jordão

  • Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired

    R Quirion;A Wilson;W Rowe;I Aubert

  • Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

    Emmanuel Thévenot;Jessica F. Jordão;Meaghan A. O'Reilly;Kelly Markham

  • The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging.

    Laura M. Vecchio;Laura M. Vecchio;Ying Meng;Ying Meng;Kristiana Xhima;Kristiana Xhima;Nir Lipsman;Nir Lipsman

  • Regeneration in the adult mammalian CNS: guided by development

    Isabelle Aubert;Jean-Luc Ridet;Fred H Gage

  • Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

    Tiffany Scarcelli;Jessica F. Jordão;Jessica F. Jordão;Meaghan A. O'Reilly;Nicholas Ellens

  • Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

    R Quirion;I Aubert;P A Lapchak;R P Schaum

  • MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors.

    Ying Meng;Ying Meng;Christopher B Pople;Suganth Suppiah;Maheleth Llinas

  • p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

    Katya J Park;Carlos Ayala Grosso;Carlos Ayala Grosso;Isabelle Aubert;David R Kaplan

  • Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain.

    Isabelle Aubert;Danielle Cécyre;Serge Gauthier;Rémi Quirion

  • Gene delivery to the spinal cord using MRI-guided focused ultrasound.

    Danielle Weber-Adrian;Danielle Weber-Adrian;Emmanuel Thévenot;Emmanuel Thévenot;Meaghan A. O'Reilly;Wendy Oakden;Wendy Oakden

  • Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.

    Ying Meng;Ying Meng;Agessandro Abrahao;Agessandro Abrahao;Chinthaka C Heyn;Chinthaka C Heyn;Allison J Bethune;Allison J Bethune

  • Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation.

    Isabelle Aubert;Jean‐Luc Ridet;Melitta Schachner;Geneviève Rougon

  • Cholinergic markers in aged cognitively impaired Long-Evans rats.

    I. Aubert;W. Rowe;M.J. Meaney;S. Gauthier

Frequent Co-Authors

Clement Hamani
Clement Hamani University of Toronto
Dalia M. Araujo
Dalia M. Araujo McGill University
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Melitta Schachner
Melitta Schachner Rutgers, The State University of New Jersey
John G. Sled
John G. Sled University of Toronto
Sandra E. Black
Sandra E. Black University of Toronto
Nathan McDannold
Nathan McDannold Brigham and Women's Hospital
Elizabeth M. Simpson
Elizabeth M. Simpson University of British Columbia
Tatsunori Seki
Tatsunori Seki Tokyo Medical University

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