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Sebastian Kügler

Sebastian Kügler

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
14610
World Ranking
9673
National Ranking
702

Overview

Sebastian Kügler is affiliated with the University of Göttingen in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a secondary focus on Medicine. Within these domains, Kügler has contributed extensively to Molecular Biology, Neurology, and Cellular and Molecular Neuroscience, alongside notable engagement in Physiology and Genetics.

The scientist's work addresses a range of topics in neurological and molecular research. Key areas include:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • RNA Interference and Gene Delivery
  • Botulinum Toxin and Related Neurological Disorders
  • Pluripotent Stem Cells Research
  • Endoplasmic Reticulum Stress and Disease
  • Alzheimer's disease research and treatments

Kügler has published in several scientific journals, with frequent contributions to:

  • Scientific Reports
  • Cells
  • Journal of Neurochemistry
  • Human Molecular Genetics
  • Molecular and Cellular Neuroscience

Among recent papers authored or co-authored by Kügler are:

  • "Syntenin-knock out reduces exosome turnover and viral transduction," 2021, Scientific Reports
  • "Dopamine promotes the neurodegenerative potential of β-synuclein," 2020, Journal of Neurochemistry
  • "Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery," 2021, Scientific Reports
  • "Dementia with Lewy bodies-associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions," 2021, Human Molecular Genetics
  • "The relevance of synuclein autoantibodies as a biomarker for Parkinson's disease," 2022, Molecular and Cellular Neuroscience

Their network of frequent co-authors includes Mathias Bähr, Kristian Leite, Sameehan Mahajani, Pretty Garg, and Sofia Guerin Darvas.

Best Publications

  • Depletion of microglia and inhibition of exosome synthesis halt tau propagation

    Hirohide Asai;Seiko Ikezu;Satoshi Tsunoda;Maria Medalla

  • Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.

    Jasper Akerboom;Nicole Carreras Calderón;Nicole Carreras Calderón;Nicole Carreras Calderón;Lin Tian;Lin Tian;Sebastian Wabnig

  • Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

    Damla Pinar Karpinar;Madhu Babu Gajula Balija;Sebastian Kügler;Felipe Opazo

  • Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area.

    S Kügler;E Kilic;M Bähr

  • Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, and pten Gene Deletion

    Takuji Kurimoto;Yuqin Yin;Kumiko Omura;Hui-ya Gilbert

  • Sumoylation inhibits α-synuclein aggregation and toxicity

    Petranka Krumova;Erik Meulmeester;Manuel Garrido;Marilyn Tirard

  • Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

    Olaf Eberhardt;Rainer V. Coelln;Sebastian Kügler;Jörg Lindenau

  • Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease.

    Isabel Lastres-Becker;Angel J. García-Yagüe;Angel J. García-Yagüe;Robert H. Scannevin;María J. Casarejos

  • Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors.

    S. Kügler;L. Meyn;H. Holzmüller;E. Gerhardt

  • Reorganization of cortical population activity imaged throughout long-term sensory deprivation

    David J Margolis;Henry Lütcke;Kristina Schulz;Kristina Schulz;Florent Haiss

  • Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

    Wilfried Roth;Stefan Isenmann;Ulrike Naumann;Sebastian Kügler

  • Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo.

    Z. Shevtsova;J. M. I. Malik;U. Michel;M. Bähr

  • HDAC1 Regulates Fear Extinction in Mice

    Sanaz Bahari-Javan;Andrea Maddalena;Cemil Kerimoglu;Jessica Wittnam

  • Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice.

    Henry Lütcke;Masanori Murayama;Thomas Hahn;David J. Margolis

  • The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

    Rita Machado de Oliveira;Hugo Vicente Miranda;Laetitia Francelle;Raquel Pinho;Raquel Pinho

  • Optogenetic stimulation of the auditory pathway

    Victor H. Hernandez;Anna Gehrt;Kirsten Reuter;Zhizi Jing

  • Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor.

    Damian J. Haydon−Wallace;Stephan Meyer zum Alten Borgloh;Simone Astori;Ying Yang

  • Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer.

    Hiroshi Tomita;Eriko Sugano;Hiromu Yawo;Toru Ishizuka

  • Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

    Marcel Kunadt;Katrin Eckermann;Anne Stuendl;Jing Gong;Jing Gong

  • Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.

    Antonio Cuadrado;Antonio Cuadrado;Sebastian Kügler;Isabel Lastres-Becker;Isabel Lastres-Becker

Frequent Co-Authors

Mathias Bähr
Mathias Bähr University of Göttingen
Stefan Isenmann
Stefan Isenmann Friedrich Schiller University Jena
Jörg B. Schulz
Jörg B. Schulz RWTH Aachen University
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Melitta Schachner
Melitta Schachner Rutgers, The State University of New Jersey
Michael Weller
Michael Weller University of Zurich
Tobias Moser
Tobias Moser University of Göttingen
Isabelle Aubert
Isabelle Aubert Sunnybrook Health Science Centre
Luís Pereira de Almeida
Luís Pereira de Almeida University of Coimbra
Paul Lingor
Paul Lingor Technical University of Munich

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