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Neuroscience

D-Index
76
Citations
34606
World Ranking
1887
National Ranking
36

Overview

Fritjof Helmchen is affiliated with the University of Zurich in Switzerland. Their research primarily focuses on neuroscience, with substantial contributions in related fields such as biochemistry, genetics, and molecular biology.

The main fields of study covered by their work include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology

The subfields of their research encompass:

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Biophysics
  • Molecular Biology
  • Neurology

The topics frequently addressed in their publications reflect a broad interest in brain function and neural mechanisms, such as:

  • Neural dynamics and brain function
  • Neuroscience and Neuropharmacology Research
  • Photoreceptor and optogenetics research
  • Advanced Fluorescence Microscopy Techniques
  • Memory and Neural Mechanisms
  • Cell Image Analysis Techniques
  • Functional Brain Connectivity Studies

Notable recent papers authored by Fritjof Helmchen include:

  • Value-guided remapping of sensory cortex by lateral orbitofrontal cortex, 2020, Nature
  • A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging, 2021, Nature Neuroscience
  • Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging, 2020, Nature Neuroscience
  • Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes, 2021, Molecular Psychiatry
  • Cortical Excitation:Inhibition Imbalance Causes Abnormal Brain Network Dynamics as Observed in Neurodevelopmental Disorders, 2020, Cerebral Cortex

Frequent collaborators in their research include:

  • Fabian F. Voigt
  • Peter Rupprecht
  • Chris Lewis
  • Adriano Aguzzi
  • Yaroslav Sych

Several scientific journals and platforms have published their work multiple times, with the most frequent publication venues being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Neuroscience
  • Cell Reports

Best Publications

  • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

    A. Nimmerjahn;F. Kirchhoff;F. Helmchen

  • Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.

    Linda Madisen;Aleena R. Garner;Daisuke Shimaoka;Amy S. Chuong

  • Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex

    David Kleinfeld;Partha P. Mitra;Fritjof Helmchen;Winfried Denk

  • Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo

    Axel Nimmerjahn;Frank Kirchhoff;Jason N D Kerr;Fritjof Helmchen

  • A Miniature Head-Mounted Two-Photon Microscope: High-Resolution Brain Imaging in Freely Moving Animals

    Fritjof Helmchen;Michale S. Fee;David W. Tank;Winfried Denk

  • Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

    Fritjof Helmchen;K. Imoto;Bert Sakmann

  • high-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision

    Benjamin F Grewe;Dominik Langer;Hansjörg Kasper;Björn M Kampa

  • Imaging input and output of neocortical networks in vivo

    Jason N. D. Kerr;David Greenberg;Fritjof Helmchen

  • Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

    Tanjew Dittgen;Axel Nimmerjahn;Shoji Komai;Pawel Licznerski

  • Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat.

    J. G. G. Borst;F. Helmchen;B. Sakmann

  • In vivo dendritic calcium dynamics in deep layer cortical pyramidal neurons

    Fritjof Helmchen;Karel Svoboda;Winfried Denk;David W. Tank

  • Imaging cellular network dynamics in three dimensions using fast 3D laser scanning.

    Werner Göbel;Björn M Kampa;Fritjof Helmchen

  • Barrel cortex function

    Dirk Feldmeyer;Michael Brecht;Fritjof Helmchen;Carl C. H. Petersen

  • Fast two-layer two-photon imaging of neuronal cell populations using an electrically tunable lens

    Benjamin F. Grewe;Fabian F. Voigt;Marcel van ’t Hoff;Fritjof Helmchen

  • Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

    Jerry L. Chen;Stefano Carta;Joana Soldado-Magraner;Bernard L. Schneider

  • Calcium dynamics associated with a single action potential in a CNS presynaptic terminal

    F. Helmchen;J. G. G. Borst;B. Sakmann

  • Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

    A. S. Wahl;A. S. Wahl;W. Omlor;J. C. Rubio;J. L. Chen

  • The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

    Fabian F Voigt;Daniel Kirschenbaum;Evgenia Platonova;Stéphane Pagès

  • Live imaging of neurogenesis in the adult mouse hippocampus

    Gregor-Alexander Pilz;Sara Bottes;Marion Betizeau;Marion Betizeau;David Josef Jörg;David Josef Jörg

  • High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision

    Unknown

  • Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel Cortex

    Jason N. D. Kerr;Christiaan P. J. de Kock;David S. Greenberg;Randy M. Bruno

  • Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

    Karel Svoboda;Karel Svoboda;Fritjof Helmchen;Winfried Denk;David W. Tank

  • Supralinear Ca2+ Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo

    Jack Waters;Matthew Larkum;Bert Sakmann;Fritjof Helmchen

  • Dendritic Spikes in Apical Dendrites of Neocortical Layer 2/3 Pyramidal Neurons

    Matthew Evan Larkum;Jack Waters;Bert Sakmann;Fritjof Helmchen

Frequent Co-Authors

Markus Rudin
Markus Rudin ETH Zurich
David W. Tank
David W. Tank Princeton University
Bruno Weber
Bruno Weber University of Zurich
Karl J. Friston
Karl J. Friston University College London
Martin E. Schwab
Martin E. Schwab University of Zurich
Rosalyn J. Moran
Rosalyn J. Moran King's College London
Robert Leech
Robert Leech King's College London
David Kleinfeld
David Kleinfeld University of California, San Diego
Ursula Keller
Ursula Keller ETH Zurich

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