The scientist’s investigation covers issues in Neuroscience, Neocortex, Microscopy, Microscope and Anatomy. Neuroscience connects with themes related to Neurite in his study. His Neocortex research is multidisciplinary, incorporating perspectives in Preclinical imaging, Somatosensory system, Barrel cortex, Dendrite and Calcium imaging.
In his work, Fluorescence-lifetime imaging microscopy, Optical fiber and Image processing is strongly intertwined with Two-photon excitation microscopy, which is a subfield of Microscopy. His research investigates the connection with Microscope and areas like Laser which intersect with concerns in Biomedical engineering and Functional imaging. His Anatomy research integrates issues from Biophysics and Central nervous system, Neuroglia, Blood–brain barrier.
Fritjof Helmchen mostly deals with Neuroscience, Neocortex, Calcium imaging, Two-photon excitation microscopy and Sensory system. His study involves Stimulus, Barrel cortex, Premovement neuronal activity, Somatosensory system and Biological neural network, a branch of Neuroscience. The concepts of his Neocortex study are interwoven with issues in Preclinical imaging, Dendrite, Anatomy and Visual cortex.
His Calcium imaging research includes themes of Calcium signaling, Neural coding, Cortex, Tactile stimuli and Brain mapping. Fritjof Helmchen interconnects Biophysics and Microscopy in the investigation of issues within Two-photon excitation microscopy. His Microscopy study integrates concerns from other disciplines, such as Microscope, Laser and Fluorescence-lifetime imaging microscopy.
His primary areas of study are Neuroscience, Calcium imaging, Sensory system, Stimulus and Premovement neuronal activity. His research combines Serotonergic and Neuroscience. His work deals with themes such as Resampling, Noise and Inference, which intersect with Calcium imaging.
His studies deal with areas such as Somatosensory system and Posterior parietal cortex as well as Sensory system. The Somatosensory system study combines topics in areas such as Dorsum, Anatomy and Spinal cord. His research integrates issues of Cortex and Auditory area in his study of Neocortex.
His primary scientific interests are in Neuroscience, Calcium imaging, Somatosensory system, Sensory system and Brain mapping. The study incorporates disciplines such as Serotonergic and Serotonin in addition to Neuroscience. His research in Calcium imaging focuses on subjects like Barrel cortex, which are connected to Auditory area, Cortex and Neocortex.
His work on Sensory cortex and Whisking in animals as part of general Somatosensory system research is often related to Lateral Orbitofrontal Cortex and Value, thus linking different fields of science. His Premovement neuronal activity research includes elements of Hippocampal formation, Spatial light modulator, Optical fiber and Brain circuit. The various areas that Fritjof Helmchen examines in his Optogenetics study include Photostimulation, Fluoxetine and Cognition.
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Deep tissue two-photon microscopy
Fritjof Helmchen;Winfried Denk.
Nature Methods (2005)
Fluctuations and stimulus−induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex
David Kleinfeld;Partha P. Mitra;Fritjof Helmchen;Winfried Denk.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Axel Nimmerjahn;Frank Kirchhoff;Jason N D Kerr;Fritjof Helmchen.
Nature Methods (2004)
Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.
Linda Madisen;Aleena R. Garner;Daisuke Shimaoka;Amy S. Chuong.
A Miniature Head-Mounted Two-Photon Microscope: High-Resolution Brain Imaging in Freely Moving Animals
Fritjof Helmchen;Michale S. Fee;David W. Tank;Winfried Denk.
Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons
Fritjof Helmchen;K. Imoto;Bert Sakmann.
Biophysical Journal (1996)
high-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision
Benjamin F Grewe;Dominik Langer;Hansjörg Kasper;Björn M Kampa.
Nature Methods (2010)
Imaging input and output of neocortical networks in vivo
Jason N. D. Kerr;David Greenberg;Fritjof Helmchen.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo
Tanjew Dittgen;Axel Nimmerjahn;Shoji Komai;Pawel Licznerski.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat.
J. G. G. Borst;F. Helmchen;B. Sakmann.
The Journal of Physiology (1995)
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