2015 - Member of the National Academy of Sciences
2015 - The Brain Prize, Lundbeck Foundation For invention, refinement and use of two-photon microscopy to provide detailed, dynamic images of activity in individual nerve cells, dendrites and synapses, thereby transforming the study of development, plasticity and functional circuitry of the brain
His scientific interests lie mostly in Neuroscience, Anatomy, Dendritic spine, Barrel cortex and Cerebral cortex. He focuses mostly in the field of Neuroscience, narrowing it down to topics relating to Synaptic plasticity and, in certain cases, Long-term potentiation. The various areas that he examines in his Anatomy study include Neocortex, Biophysics, Sensory system and GCaMP, Calcium imaging.
His work deals with themes such as Neuroplasticity and In vivo, which intersect with Neocortex. In the field of Dendritic spine, his study on Dendritic filopodia overlaps with subjects such as Time constant. The Cerebral cortex study combines topics in areas such as Electrophysiology, Photostimulation and Somatosensory system.
Karel Svoboda mainly focuses on Neuroscience, Barrel cortex, Dendritic spine, Anatomy and Biophysics. In most of his Neuroscience studies, his work intersects topics such as Synaptic plasticity. His Barrel cortex study integrates concerns from other disciplines, such as Photostimulation, Neocortex, Cerebral cortex, Excitatory postsynaptic potential and Neuroplasticity.
He works mostly in the field of Excitatory postsynaptic potential, limiting it down to topics relating to Postsynaptic potential and, in certain cases, Neuron and Synapse, as a part of the same area of interest. His Dendritic spine research includes elements of Long-term potentiation, Calcium channel, Spine and Cell biology. In his study, Microscopy is inextricably linked to Fluorescence, which falls within the broad field of Biophysics.
The scientist’s investigation covers issues in Neuroscience, Biological neural network, Motor cortex, Optogenetics and Sensory system. His work on Electrophysiology, Neural activity and Excitatory postsynaptic potential as part of general Neuroscience study is frequently linked to Dynamics and Attractor, therefore connecting diverse disciplines of science. His work focuses on many connections between Electrophysiology and other disciplines, such as Calcium imaging, that overlap with his field of interest in Soma, Dendrite, Pyramidal cell and Dendritic spine.
His work in Biological neural network addresses issues such as Photostimulation, which are connected to fields such as Neocortex and Inhibitory postsynaptic potential. He interconnects Cluster analysis and Thalamus in the investigation of issues within Motor cortex. His Sensory system research is multidisciplinary, relying on both Somatosensory system, Perception and Cortex.
His primary areas of investigation include Neuroscience, Optogenetics, Biological neural network, Calcium imaging and Motor cortex. His studies in Frontal cortex, Sensory system, Excitatory postsynaptic potential, Inhibitory postsynaptic potential and GABAergic are all subfields of Neuroscience research. He combines subjects such as Temporal resolution, Fluorescence, Förster resonance energy transfer, Premovement neuronal activity and Zebrafish with his study of Optogenetics.
His Biological neural network research incorporates themes from Neural activity, Resolution and Volumetric imaging. His Calcium imaging research is multidisciplinary, incorporating elements of Preclinical imaging, Neuron and Green fluorescent protein. His research in Motor cortex tackles topics such as Electrophysiology which are related to areas like Soma, Cluster analysis, Dendrite, Pyramidal cell and Dendritic spine.
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Ultrasensitive fluorescent proteins for imaging neuronal activity.
Tsai-Wen Chen;Trevor J. Wardill;Trevor J. Wardill;Yi Sun;Stefan R. Pulver.
Biological applications of optical forces
Karel Svoboda;Steven M. Block.
Annual Review of Biophysics and Biomolecular Structure (1994)
Direct observation of kinesin stepping by optical trapping interferometry
Karel Svoboda;Christoph F. Schmidt;Christoph F. Schmidt;Bruce J. Schnapp;Steven M. Block.
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Lin Tian;S Andrew Hires;Tianyi Mao;Daniel Huber.
Nature Methods (2009)
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Joshua T. Trachtenberg;Brian E. Chen;Graham W. Knott;Guoping Feng.
Experience-dependent structural synaptic plasticity in the mammalian brain.
Anthony Holtmaat;Karel Svoboda.
Nature Reviews Neuroscience (2009)
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Song-Hai Shi;Yasunori Hayashi;Ronald S. Petralia;Shahid H. Zaman.
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
M. Maletic-Savatic;R. Malinow;K. Svoboda.
Structure and function of dendritic spines.
Esther A Nimchinsky;Bernardo L Sabatini;Karel Svoboda.
Annual Review of Physiology (2002)
Optimization of a GCaMP calcium indicator for neural activity imaging.
Jasper Akerboom;Tsai Wen Chen;Trevor J. Wardill;Lin Tian;Lin Tian.
The Journal of Neuroscience (2012)
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