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Neuroscience

D-Index
131
Citations
90283
World Ranking
266
National Ranking
163

Research.com Recognitions

  • 2015 - The Brain Prize, Lundbeck Foundation For invention, refinement and use of two-photon microscopy to provide detailed, dynamic images of activity in individual nerve cells, dendrites and synapses, thereby transforming the study of development, plasticity and functional circuitry of the brain
  • 2015 - Member of the National Academy of Sciences

Overview

Karel Svoboda is affiliated with the Allen Institute for Brain Science in the United States. Their research primarily focuses on neuroscience and intersects with biochemistry, genetics, and molecular biology. They have contributed extensively to subfields such as cognitive neuroscience, cellular and molecular neuroscience, biophysics, molecular biology, and electrical and electronic engineering.

The main topics of their research include:

  • Neural dynamics and brain function
  • Neuroscience and Neural Engineering
  • Neuroscience and Neuropharmacology Research
  • Photoreceptor and optogenetics research
  • Advanced Fluorescence Microscopy Techniques
  • Advanced Memory and Neural Computing
  • Cell Image Analysis Techniques

Karel Svoboda has published extensively in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience
  • eLife
  • Cell
  • Nature Communications

Recent published papers include:

  • "Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings," 2021, Science
  • "Fast and sensitive GCaMP calcium indicators for imaging neural populations," 2023, Nature
  • "EASI-FISH for thick tissue defines lateral hypothalamus spatio-molecular organization," 2021, Cell
  • "The Mind of a Mouse," 2020, Cell
  • "A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement," 2022, Cell

Frequent co-authors in their research collaborations include:

  • Susu Chen
  • Matteo Carandini
  • Nuo Li
  • Nicholas A. Steinmetz
  • Wyatt Korff

Karel Svoboda has authored a book published by the University of West Bohemia titled Od praxe k teorii a zpět ve vyučování češtině II in 2021.

Their work has been recognized by awards such as the Member of the National Academy of Sciences in 2015 and The Brain Prize from the Lundbeck Foundation, also in 2015, which was awarded for the invention, refinement, and use of two-photon microscopy to provide detailed, dynamic images of activity in nerve cells, dendrites, and synapses. This technology has impacted the study of brain development, plasticity, and functional circuitry.

Best Publications

  • Ultrasensitive fluorescent proteins for imaging neuronal activity.

    Tsai Wen Chen;Trevor J. Wardill;Trevor J. Wardill;Yi Sun;Stefan R. Pulver

  • Biological applications of optical forces

    Karel Svoboda;Steven M. Block

  • Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

    Joshua T. Trachtenberg;Brian E. Chen;Graham W. Knott;Guoping Feng

  • Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

    Lin Tian;S Andrew Hires;Tianyi Mao;Daniel Huber

  • Fully integrated silicon probes for high-density recording of neural activity

    James J Jun;Nicholas A Steinmetz;Nicholas A Steinmetz;Nicholas A Steinmetz;Joshua H Siegle;Daniel J Denman

  • Experience-dependent structural synaptic plasticity in the mammalian brain.

    Anthony Holtmaat;Karel Svoboda

  • Shared and distinct transcriptomic cell types across neocortical areas

    Bosiljka Tasic;Zizhen Yao;Lucas T. Graybuck;Kimberly A. Smith

  • Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

    Song-Hai Shi;Yasunori Hayashi;Ronald S. Petralia;Shahid H. Zaman

  • A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

    Linda Madisen;Tianyi Mao;Tianyi Mao;Henner Koch;Jia Min Zhuo

  • Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

    M. Maletic-Savatic;R. Malinow;K. Svoboda

  • Optimization of a GCaMP calcium indicator for neural activity imaging.

    Jasper Akerboom;Tsai Wen Chen;Trevor J. Wardill;Lin Tian;Lin Tian

  • Structure and function of dendritic spines.

    Esther A Nimchinsky;Bernardo L Sabatini;Karel Svoboda

  • Transient and Persistent Dendritic Spines in the Neocortex In Vivo

    Anthony J.G.D. Holtmaat;Joshua T. Trachtenberg;Linda Wilbrecht;Gordon M. Shepherd

  • Principles of Two-Photon Excitation Microscopy and Its Applications to Neuroscience

    Karel Svoboda;Ryohei Yasuda

  • High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

    Hod Dana;Hod Dana;Yi Sun;Yi Sun;Boaz Mohar;Brad K. Hulse

  • The subcellular organization of neocortical excitatory connections

    Leopoldo Petreanu;Tianyi Mao;Scott M. Sternson;Karel Svoboda

  • Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

    Anthony Holtmaat;Anthony Holtmaat;Tobias Bonhoeffer;David K Chow;Jyoti Chuckowree

  • Sensitive red protein calcium indicators for imaging neural activity

    Hod Dana;Boaz Mohar;Boaz Mohar;Yi Sun;Sujatha Narayan

  • Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections

    Leopoldo Petreanu;Daniel Huber;Daniel Huber;Aleksander Sobczyk;Aleksander Sobczyk;Karel Svoboda;Karel Svoboda

  • In vivo dendritic calcium dynamics in neocortical pyramidal neurons

    Karel Svoboda;Winfried Denk;David Kleinfeld;David Kleinfeld;David W. Tank

  • A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

    Linda Madisen;Tianyi Mao;Henner Koch;Jia-min Zhuo

Frequent Co-Authors

Gordon M. Shepherd
Gordon M. Shepherd Yale School of Medicine
Bernardo L. Sabatini
Bernardo L. Sabatini Harvard Medical School
Zachary F. Mainen
Zachary F. Mainen Champalimaud Foundation
Charles R. Gerfen
Charles R. Gerfen National Institutes of Health
Vivek Jayaraman
Vivek Jayaraman Howard Hughes Medical Institute
Anthony Holtmaat
Anthony Holtmaat University of Geneva
Graham Knott
Graham Knott École Polytechnique Fédérale de Lausanne
David W. Tank
David W. Tank Princeton University
Linda Wilbrecht
Linda Wilbrecht University of California, Berkeley
Michael S. Okun
Michael S. Okun University of Florida

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