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Neuroscience

D-Index
97
Citations
54490
World Ranking
816
National Ranking
444

Overview

Hongkui Zeng is affiliated with the Allen Institute for Brain Science in the United States. Their research spans numerous areas within biochemistry, genetics, molecular biology, and neuroscience. The scientist has a significant output in molecular biology, cognitive neuroscience, biophysics, cellular and molecular neuroscience, and neurology.

Key topics in Zeng's work include:

  • Single-cell and spatial transcriptomics
  • Neural dynamics and brain function
  • Cell image analysis techniques
  • Neuroinflammation and neurodegeneration mechanisms
  • Neuroscience and neuropharmacology research
  • Advanced fluorescence microscopy techniques
  • RNA research and splicing

Zeng has published numerous important papers with notable recent works including:

  • The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas, 2020, Cell
  • A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation, 2021, Cell
  • Survey of spiking in the mouse visual system reveals functional hierarchy, 2021, Nature
  • A multimodal cell census and atlas of the mammalian primary motor cortex, 2021, Nature
  • Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells, 2020, Cell

Frequent co-authors in Zeng's research include Bosiljka Tasic, Zizhen Yao, Kimberly A. Smith, Tanya L. Daigle, and Michael Hawrylycz, reflecting active collaboration within the neuroscience community.

Zeng has published extensively in several academic venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Neuroscience
  • Cell Reports
  • Cell

The body of work produced by Zeng integrates molecular and cellular neuroscience with advanced imaging and transcriptomic techniques, contributing to understanding brain structure and function at multiple scales. The combination of single-cell and spatial transcriptomics with neural dynamics studies is a defining characteristic of their research portfolio.

Best Publications

  • A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

    Linda Madisen;Theresa A Zwingman;Susan M Sunkin;Seung Wook Oh

  • A mesoscale connectome of the mouse brain

    Seung Wook Oh;Julie A. Harris;Lydia Ng;Brent Winslow

  • Shared and distinct transcriptomic cell types across neocortical areas

    Bosiljka Tasic;Zizhen Yao;Lucas T. Graybuck;Kimberly A. Smith

  • Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

    Bosiljka Tasic;Vilas Menon;Thuc Nghi Nguyen;Tae Kyung Kim

  • Conserved cell types with divergent features in human versus mouse cortex.

    Rebecca D. Hodge;Trygve E. Bakken;Jeremy A. Miller;Kimberly A. Smith

  • A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

    Linda Madisen;Tianyi Mao;Tianyi Mao;Henner Koch;Jia Min Zhuo

  • The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas.

    Quanxin Wang;Song-Lin Ding;Yang Li;Josh Royall

  • Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.

    Linda Madisen;Aleena R. Garner;Daisuke Shimaoka;Amy S. Chuong

  • A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.

    Zizhen Yao;Cindy T.J. van Velthoven;Thuc Nghi Nguyen;Jeff Goldy

  • The G protein-coupled receptor repertoires of human and mouse.

    Demetrios K. Vassilatis;John G. Hohmann;Hongkui Zeng;Fusheng Li

  • A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

    Unknown

  • Neuronal cell-type classification: challenges, opportunities and the path forward

    Hongkui Zeng;Joshua R. Sanes

  • A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

    Tanya L. Daigle;Linda Madisen;Travis A. Hage;Matthew T. Valley

  • Hierarchical organization of cortical and thalamic connectivity

    Julie A. Harris;Stefan Mihalas;Karla E. Hirokawa;Jennifer D. Whitesell

  • Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

    Mazen A. Kheirbek;Liam J. Drew;Nesha S. Burghardt;Daniel O. Costantini

  • Comparative cellular analysis of motor cortex in human, marmoset and mouse

    Trygve E. Bakken;Nikolas L. Jorstad;Qiwen Hu;Blue B. Lake

  • Single-nucleus and single-cell transcriptomes compared in matched cortical cell types.

    Trygve E. Bakken;Rebecca D. Hodge;Jeremy A. Miller;Zizhen Yao

  • Survey of spiking in the mouse visual system reveals functional hierarchy

    Joshua H. Siegle;Xiaoxuan Jia;Séverine Durand;Sam Gale

  • A light-entrainment mechanism for the Drosophila circadian clock.

    Hongkui Zeng;Zuwei Qian;Michael P. Myers;Michael Rosbash

  • Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory.

    Hongkui Zeng;Sumantra Chattarji;Sumantra Chattarji;Michaela Barbarosie;Laure Rondi-Reig

  • Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

    Tsuyoshi Miyakawa;Lorene M. Leiter;David J. Gerber;Raul R. Gainetdinov

  • Mind matters: placebo enhances reward learning in Parkinson's disease

    Liane Schmidt;Erin Kendall Braun;Tor D Wager;Daphna Shohamy

  • A Taxonomy of Transcriptomic Cell Types Across the Isocortex and Hippocampal Formation

    Zizhen Yao;Thuc Nghi Nguyen;Cindy T. J. van Velthoven;Jeff Goldy

  • A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

    Linda Madisen;Tianyi Mao;Henner Koch;Jia-min Zhuo

Frequent Co-Authors

Ed S. Lein
Ed S. Lein University of Washington
Michael Hawrylycz
Michael Hawrylycz Allen Institute for Brain Science
Zizhen Yao
Zizhen Yao Allen Institute for Brain Science
Christof Koch
Christof Koch Allen Institute for Brain Science
Julie A. Harris
Julie A. Harris University of California, San Francisco
Jonathan T. Ting
Jonathan T. Ting Allen Institute for Brain Science
Amy Bernard
Amy Bernard Kavli Foundation
Lydia Ng
Lydia Ng Allen Institute for Brain Science
Jeffrey G. Ojemann
Jeffrey G. Ojemann University of Washington
Stefan Mihalas
Stefan Mihalas Allen Institute for Brain Science

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