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Biology and Biochemistry
USA
2026
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Neuroscience
USA
2026

D-Index & Metrics

Neuroscience

D-Index
164
Citations
86631
World Ranking
94
National Ranking
62

Biology and Biochemistry

D-Index
162
Citations
86373
World Ranking
117
National Ranking
90

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Member of the National Academy of Medicine (NAM)

Overview

John L.R. Rubenstein is affiliated with the University of California, San Francisco in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions in Neuroscience. Their publication record includes 82 works in Biochemistry, Genetics and Molecular Biology and 42 in Neuroscience.

Their subfields of study involve molecular and cellular mechanisms, including Molecular Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics, and Neurology. Key topics covered in their research encompass:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Neurogenesis and neuroplasticity mechanisms
  • Genetics and Neurodevelopmental Disorders
  • Single-cell and spatial transcriptomics
  • Autism Spectrum Disorder Research
  • Neuroscience and Neuropharmacology Research

Their recent papers reflect a focus on molecular and developmental neuroscience as well as gene regulation. Selected publications include:

  • Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors (2020, Neuron)
  • A Chromatin Accessibility Atlas of the Developing Human Telencephalon (2020, Cell)
  • Ultraconserved enhancer function does not require perfect sequence conservation (2021, Nature Genetics)
  • Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog (2020, Cell Reports)
  • Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin (2022, Nature Neuroscience)

The scientist collaborates frequently with a group of co-authors, including Athéna R. Ypsilanti, Alex S. Nord, Susan Lindtner, Siavash Fazel Darbandi, and Stephan Sanders. Their work has been published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Proceedings of the National Academy of Sciences, Development, and eLife.

John L.R. Rubenstein has been recognized by several professional organizations, holding memberships and fellowships including:

  • Member of the National Academy of Sciences (2020)
  • Fellow of the American Academy of Arts and Sciences (2016)
  • Member of the National Academy of Medicine (NAM) (2006)

Best Publications

  • Model of autism: increased ratio of excitation/inhibition in key neural systems

    J. L. R. Rubenstein;M. M. Merzenich

  • Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes

    S. A. Anderson;D. D. Eisenstat;L. Shi;J. L. R. Rubenstein

  • Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

    J. R. Sanes;J. L. R. Rubenstein;J.-F. Nicolas

  • Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage

    Jessica A. Gorski;Tiffany Talley;Mengsheng Qiu;Luis Puelles

  • Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

    Hsiao Tuan Chao;Hongmei Chen;Rodney C. Samaco;Mingshan Xue;Mingshan Xue

  • Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

    L. Sussel;O. Marin;S. Kimura;J. L. R. Rubenstein

  • A long, remarkable journey: tangential migration in the telencephalon

    Oscar Marín;John L. R. Rubenstein

  • Cell migration in the forebrain.

    Oscar Marín;John L.R. Rubenstein

  • Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1

    Luis Puelles;Ellen Kuwana;Eduardo Puelles;Alessandro Bulfone

  • FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

    Weilan Ye;Kenji Shimamura;John L.R Rubenstein;Mary A Hynes

  • Tbr1 Regulates Differentiation of the Preplate and Layer 6

    Robert F. Hevner;Limin Shi;Nicholas J Justice;Yi Ping Hsueh

  • New neurons follow the flow of cerebrospinal fluid in the adult brain.

    Kazunobu Sawamoto;Hynek Wichterle;Oscar Gonzalez-Perez;Jeremy A. Cholfin

  • New insights into the classification and nomenclature of cortical GABAergic interneurons

    Javier DeFelipe;Pedro L. López-Cruz;Ruth Benavides-Piccione;Ruth Benavides-Piccione;Concha Bielza

  • Inductive interactions direct early regionalization of the mouse forebrain

    Kenji Shimamura;John L R Rubenstein

  • Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization

    Luis Puelles;John L.R. Rubenstein

  • Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

    Vikaas S. Sohal;John L. R. Rubenstein

  • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

    J. Briscoe;L. Sussel;P. Serup;D. Hartigan-O'Connor

  • The endocannabinoid system controls key epileptogenic circuits in the hippocampus.

    Krisztina Monory;Federico Massa;Federico Massa;Michaela Egertová;Matthias Eder

  • Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

    A. Bulfone;L. Puelles;M. H. Porteus;M. A. Frohman

  • Distinct cortical migrations from the medial and lateral ganglionic eminences.

    S.A. Anderson;O. Marin;C. Horn;K. Jennings

  • Forebrain gene expression domains and the evolving prosomeric model

    Luis Puelles;John L.R. Rubenstein

Frequent Co-Authors

Luis Puelles
Luis Puelles University of Murcia
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Arturo Alvarez-Buylla
Arturo Alvarez-Buylla University of California, San Francisco
Salvador Martinez
Salvador Martinez Miguel Hernandez University
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Marc Ekker
Marc Ekker University of Ottawa
Oscar Marín
Oscar Marín King's College London
Stewart A. Anderson
Stewart A. Anderson Children's Hospital of Philadelphia
Vikaas S. Sohal
Vikaas S. Sohal University of California, San Francisco
Scott C. Baraban
Scott C. Baraban University of California, San Francisco

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