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Biology and Biochemistry
UK
2026

D-Index & Metrics

Neuroscience

D-Index
111
Citations
46405
World Ranking
522
National Ranking
66

Biology and Biochemistry

D-Index
111
Citations
46528
World Ranking
936
National Ranking
51

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

François Guillemot is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with an emphasis on neuroscience. The main subfields of study in which they contribute include molecular biology, developmental neuroscience, genetics, cellular and molecular neuroscience, and neurology.

Their scientific work covers a range of topics including:

  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and neurodegeneration mechanisms
  • Genetics and neurodevelopmental disorders
  • Single-cell and spatial transcriptomics
  • RNA research and splicing
  • MicroRNA in disease regulation
  • Genomics and chromatin dynamics

Guillemot has published extensively, with frequent contributions in venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Development, Journal of Visualized Experiments, and Cell Stem Cell.

Recent notable papers include:

  • Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population, 2021, Cell Stem Cell
  • Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging, 2020, Nature Neuroscience
  • Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture, 2021, Nature Communications
  • Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation, 2023, Genes & Development
  • Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development, 2020, Development

Frequent collaborators in their research include Lachlan Harris, Piero Rigo, Cristina Dias, Robert Goldstone, and Carol Schuurmans.

Best Publications

  • Proneural genes and the specification of neural cell types

    Nicolas Bertrand;Diogo S. Castro;François Guillemot

  • neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

    Gérard Gradwohl;Andrée Dierich;Marianne LeMeur;François Guillemot

  • Control of endodermal endocrine development by Hes-1.

    J Jensen;E E Pedersen;P Galante;J Hald

  • Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

    François Guillemot;Li Ching Lo;Jane E. Johnson;Anna Auerbach

  • Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells

    Till Marquardt;Ruth Ashery-Padan;Nicole Andrejewski;Raffaella Scardigli

  • Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

    M Ishibashi;S L Ang;K Shiota;S Nakanishi

  • Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

    Toshiyuki Ohtsuka;Makoto Ishibashi;Makoto Ishibashi;Gérald Gradwohl;Shigetada Nakanishi

  • Mash1 regulates neurogenesis in the ventral telencephalon.

    Simona Casarosa;Carol Fode;François Guillemot

  • A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons

    Carol Fode;Qiufu Ma;Simona Casarosa;Siew-Lan Ang

  • Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.

    Jun Hatakeyama;Yasumasa Bessho;Kazuo Katoh;Shigeo Ookawara

  • Essential role of Mash-2 in extraembryonic development.

    François Guillemot;François Guillemot;Andras Nagy;Anna Auerbach;Janet Rossant;Janet Rossant

  • Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

    Orly L. Wapinski;Thomas Vierbuchen;Kun Qu;Qian Yi Lee

  • Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.

    Marta Nieto;Carol Schuurmans;Olivier Britz;François Guillemot

  • NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia

    Qiufu Ma;Carol Fode;Francois Guillemot;David J. Anderson

  • Neurogenesis in the embryonic and adult brain: same regulators, different roles

    Noelia Urbán;François Guillemot

  • Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

    Marjorie Jenny;Céline Uhl;Colette Roche;Isabelle Duluc

  • The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

    Carol Fode;Gérard Gradwohl;Xavier Morin;Andrée Dierich

  • Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain

    Toshiyuki Ohtsuka;Masami Sakamoto;François Guillemot;Ryoichiro Kageyama

  • Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system☆

    François Guillemot;Alexandra L. Joyner;Alexandra L. Joyner

  • Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

    Takaaki Ito;Naoko Udaka;Takuya Yazawa;Koji Okudela

Frequent Co-Authors

Ryoichiro Kageyama
Ryoichiro Kageyama Kyoto University
Magdalena Götz
Magdalena Götz Ludwig-Maximilians-Universität München
Laurent Nguyen
Laurent Nguyen University of Liège
Charles Auffray
Charles Auffray Centre national de la recherche scientifique, CNRS
Masato Nakafuku
Masato Nakafuku Cincinnati Children's Hospital Medical Center
Olivier Raineteau
Olivier Raineteau Claude Bernard University Lyon 1
Alexandra L. Joyner
Alexandra L. Joyner Memorial Sloan Kettering Cancer Center
Franck Polleux
Franck Polleux Columbia University
Benedikt Berninger
Benedikt Berninger King's College London
Janet Rossant
Janet Rossant University of Toronto

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