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Ryoichiro Kageyama

Ryoichiro Kageyama

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
122
Citations
47996
World Ranking
589
National Ranking
23

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Ryoichiro Kageyama is affiliated with Kyoto University in Japan and specializes in the fields of biochemistry, genetics, and molecular biology, with a total of 91 publications in these areas. Their research notably spans molecular biology, developmental neuroscience, cellular and molecular neuroscience, genetics, and cancer research. The subfields of their studies include:

  • Molecular Biology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Genetics
  • Cancer Research

Kageyama's main research topics focus on developmental biology and gene regulation, neurogenesis and neuroplasticity mechanisms, epigenetics and DNA methylation, congenital heart defects research, protist diversity and phylogeny, pluripotent stem cells research, and microRNA in disease regulation. The key topics they have explored are:

  • Developmental Biology and Gene Regulation
  • Neurogenesis and neuroplasticity mechanisms
  • Epigenetics and DNA Methylation
  • Congenital heart defects research
  • Protist diversity and phylogeny
  • Pluripotent Stem Cells Research
  • MicroRNA in disease regulation

Their recent papers include several published in prestigious venues such as Science, Nature, Developmental Cell, and Development. Notable publications are:

  • "Species-specific segmentation clock periods are due to differential biochemical reaction speeds," 2020, Science
  • "In vitro characterization of the human segmentation clock," 2020, Nature
  • "Coupling delay controls synchronized oscillation in the segmentation clock," 2020, Nature
  • "Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors," 2020, Developmental Cell
  • "Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain," 2020, Development

Frequent publication venues for Kageyama's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Development
  • Nature
  • Nature Communications
  • Genes & Development

Among collaborators, Kageyama has repeatedly worked with these co-authors:

  • Hiromi Shimojo
  • Kumiko Yoshioka-Kobayashi
  • Akihiro Isomura
  • Itaru Imayoshi
  • Taeko Kobayashi

Kageyama has also contributed to book publications, including one with Springer Nature, titled "Optogenetics" (2021), which has been cited in the literature.

Best Publications

  • Control of endodermal endocrine development by Hes-1.

    J Jensen;E E Pedersen;P Galante;J Hald

  • Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

    Itaru Imayoshi;Masayuki Sakamoto;Toshiyuki Ohtsuka;Keizo Takao;Keizo Takao

  • Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

    M Ishibashi;S L Ang;K Shiota;S Nakanishi

  • Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

    Toshiyuki Ohtsuka;Makoto Ishibashi;Makoto Ishibashi;Gérald Gradwohl;Shigetada Nakanishi

  • Cloning and expression of cDNA for a human thromboxane A2 receptor

    Masakazu Hirata;Yasunori Hayashi;Fumitaka Ushikubi;Yoshifumi Yokota

  • Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.

    Hiromi Hirata;Shigeki Yoshiura;Toshiyuki Ohtsuka;Yasumasa Bessho

  • Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

    Y Sasai;R Kageyama;Y Tagawa;R Shigemoto

  • Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

    Itaru Imayoshi;Masayuki Sakamoto;Masahiro Yamaguchi;Kensaku Mori

  • Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

    Hiromi Shimojo;Toshiyuki Ohtsuka;Ryoichiro Kageyama

  • The Hes gene family: repressors and oscillators that orchestrate embryogenesis

    Ryoichiro Kageyama;Toshiyuki Ohtsuka;Taeko Kobayashi

  • Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.

    Jun Hatakeyama;Yasumasa Bessho;Kazuo Katoh;Shigeo Ookawara

  • Roles of bHLH genes in neural stem cell differentiation

    Ryoichiro Kageyama;Toshiyuki Ohtsuka;Jun Hatakeyama;Ryosuke Ohsawa

  • Oscillatory control of factors determining multipotency and fate in mouse neural progenitors.

    Itaru Imayoshi;Akihiro Isomura;Yukiko Harima;Kyogo Kawaguchi

  • Potential for neural regeneration after neurotoxic injury in the adult mammalian retina

    Sotaro Ooto;Tadamichi Akagi;Ryoichiro Kageyama;Joe Akita

  • Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain

    Toshiyuki Ohtsuka;Masami Sakamoto;François Guillemot;Ryoichiro Kageyama

  • Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

    Takaaki Ito;Naoko Udaka;Takuya Yazawa;Koji Okudela

  • A Mammalian Helix-Loop-Helix Factor Structurally Related to the Product of Drosophila Proneural Gene atonal Is a Positive Transcriptional Regulator Expressed in the Developing Nervous System

    Chihiro Akazawa;Makoto Ishibashi;Chikara Shimizu;Shigetada Nakanishi

  • Dynamic expression and essential functions of Hes7 in somite segmentation

    Yasumasa Bessho;Ryoichi Sakata;Suguru Komatsu;Kohei Shiota

  • Persistent expression of helix‐loop‐helix factor HES‐1 prevents mammalian neural differentiation in the central nervous system.

    M. Ishibashi;K. Moriyoshi;Y. Sasai;K. Shiota

  • BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis

    Kinichi Nakashima;Takumi Takizawa;Takumi Takizawa;Takumi Takizawa;Wataru Ochiai;Wataru Ochiai;Makoto Yanagisawa;Makoto Yanagisawa

Frequent Co-Authors

Itaru Imayoshi
Itaru Imayoshi Kyoto University
François Guillemot
François Guillemot The Francis Crick Institute
Shigetada Nakanishi
Shigetada Nakanishi Kyoto University
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Kohei Miyazono
Kohei Miyazono University of Tokyo
Yoshiki Sasai
Yoshiki Sasai Kyoto University
Ira Pastan
Ira Pastan Center for Cancer Research
Palle Serup
Palle Serup University of Copenhagen
Hideyuki Okano
Hideyuki Okano Keio University
Masayo Takahashi
Masayo Takahashi Kyoto University

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