Freddy Radtke

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Best Publications

• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  Freddy Radtke;Anne Wilson;Gerlinde Stark;Michelle Bauer

  1814
  Citations

• Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

  Johan H. van Es;Marielle E. van Gijn;Orbicia Riccio;Maaike van den Born

  1810
  Citations

• Notch1 functions as a tumor suppressor in mouse skin.

  Michael Nicolas;Anita Wolfer;Kenneth Raj;J Alain Kummer

  1258
  Citations

• VEGF is required for growth and survival in neonatal mice

  Hans-Peter Gerber;Kenneth J. Hillan;Anne M. Ryan;Joe Kowalski

  1178
  Citations

• The role of Notch in tumorigenesis: oncogene or tumour suppressor?

  Freddy Radtke;Kenneth Raj

  1128
  Citations

• Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

  Annapoorni Rangarajan;Annapoorni Rangarajan;Claudio Talora;Ryuhei Okuyama;Michael Nicolas

  1070
  Citations

• Self-Renewal and Cancer of the Gut: Two Sides of a Coin

  Freddy Radtke;Hans Clevers

  1029
  Citations

• Notch regulation of lymphocyte development and function

  Freddy Radtke;Anne Wilson;Stephane J C Mancini;H Robson MacDonald

  799
  Citations

• Notch signaling in the immune system.

  Freddy Radtke;Nicolas Fasnacht;H. Robson MacDonald

  707
  Citations

• Transcription factor RORα is critical for nuocyte development

  See Heng Wong;See Heng Wong;Jennifer A Walker;Helen E Jolin;Lesley F Drynan

  654
  Citations

• The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.

  R Heuchel;F Radtke;O Georgiev;G Stark

  615
  Citations

• Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

  Anne Wilson;H. Robson MacDonald;Freddy Radtke

  572
  Citations

• Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

  Orbicia Riccio;Marielle E van Gijn;April C Bezdek;Luca Pellegrinet

  549
  Citations

• Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch

  Derk Amsen;Andrey Antov;Dragana Jankovic;Alan Sher

  544
  Citations

• Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

  Ute Koch;Emma Fiorini;Rui Benedito;Valerie Besseyrias

  539
  Citations

• β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

  Monica Cobas;Anne Wilson;Bettina Ernst;Stéphane J.C. Mancini

  524
  Citations

• Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

  Anita Wolfer;Anne Wilson;Mohamed Nemir;H.Robson MacDonald

  515
  Citations

• Notch and cancer: a double-edged sword

  U. Koch;F. Radtke

  495
  Citations

• Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

  F Radtke;R Heuchel;O Georgiev;M Hergersberg

  485
  Citations

• The Transcription Factor Mtf-1 Is Essential for Basal and Heavy Metal-Induced Metallothionein-I Gene-Expression

  F. Radtke;R. Heuchel;O. Georgiev;G. Stark

  0
  Citations