2023 - Research.com Biology and Biochemistry in Switzerland Leader Award
His main research concerns Cell biology, Notch signaling pathway, Cellular differentiation, Immunology and Progenitor cell. The various areas that Freddy Radtke examines in his Cell biology study include T cell and Transcription factor. Freddy Radtke combines subjects such as Cell signaling, Wnt signaling pathway and Intestinal epithelium with his study of Notch signaling pathway.
His Cellular differentiation study integrates concerns from other disciplines, such as Gliogenesis, Schwann cell, Goblet cell, Crypt and Bone marrow. His studies in Immunology integrate themes in fields like Cancer research, Metastasis, Lymphoid progenitors and Lineage commitment. He works mostly in the field of Progenitor cell, limiting it down to topics relating to Molecular biology and, in certain cases, Zinc finger, Promoter, Reporter gene, Metallothionein and Antigen.
His primary areas of investigation include Cell biology, Notch signaling pathway, Cellular differentiation, Immunology and Stem cell. His research in Cell biology intersects with topics in T cell and Cell fate determination. His Notch signaling pathway study combines topics in areas such as Cancer research and Endocrinology.
His Cellular differentiation research integrates issues from Cell signaling, HES1, Antigen and Jagged-1 Protein. His research integrates issues of Cell, Corneal epithelium, Homeostasis and Transplantation in his study of Stem cell. His study in Signal transduction is interdisciplinary in nature, drawing from both Receptor and Transcription factor.
Notch signaling pathway, Cell biology, Cancer research, Cell and Receptor are his primary areas of study. In Notch signaling pathway, Freddy Radtke works on issues like Cancer, which are connected to Inflammation. Freddy Radtke has included themes like T cell, Gene and Transcription preinitiation complex in his Cell biology study.
He has researched Cell in several fields, including Anabolism, Internal medicine, Homeostasis and Osteoblast. His Receptor research is multidisciplinary, relying on both Angiogenesis, Wound healing, Diabetes mellitus, Gamma secretase and Signal transduction. His study in Cellular differentiation extends to Stem cell with its themes.
His primary scientific interests are in Cell biology, Notch signaling pathway, Homeostasis, Cancer research and Stem cell. His work carried out in the field of Cell biology brings together such families of science as Cellular differentiation, Immunology and Bioinformatics. His biological study spans a wide range of topics, including Receptor and Signal transduction.
His work deals with themes such as Forebrain, Neurogenesis, Cell cycle, Olfactory bulb and Neural stem cell, which intersect with Notch signaling pathway. His study focuses on the intersection of Homeostasis and fields such as Cell with connections in the field of Mesenchymal stem cell, Internal medicine, Anabolism and Endocrinology. His Stem cell research incorporates themes from Endothelial stem cell, Corneal epithelium, Cornea and Niche.
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Deficient T cell fate specification in mice with an induced inactivation of Notch1.
Freddy Radtke;Anne Wilson;Gerlinde Stark;Michelle Bauer.
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H. van Es;Marielle E. van Gijn;Orbicia Riccio;Maaike van den Born.
Notch1 functions as a tumor suppressor in mouse skin.
Michael Nicolas;Anita Wolfer;Kenneth Raj;J Alain Kummer.
Nature Genetics (2003)
VEGF is required for growth and survival in neonatal mice
Hans-Peter Gerber;Kenneth J. Hillan;Anne M. Ryan;Joe Kowalski.
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Freddy Radtke;Kenneth Raj.
Nature Reviews Cancer (2003)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
Annapoorni Rangarajan;Annapoorni Rangarajan;Claudio Talora;Ryuhei Okuyama;Michael Nicolas.
The EMBO Journal (2001)
Self-Renewal and Cancer of the Gut: Two Sides of a Coin
Freddy Radtke;Hans Clevers.
Notch regulation of lymphocyte development and function
Freddy Radtke;Anne Wilson;Stephane J C Mancini;H Robson MacDonald.
Nature Immunology (2004)
Notch signaling in the immune system.
Freddy Radtke;Nicolas Fasnacht;H. Robson MacDonald.
The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.
R Heuchel;F Radtke;O Georgiev;G Stark.
The EMBO Journal (1994)
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