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Biology and Biochemistry

D-Index
75
Citations
21757
World Ranking
5279
National Ranking
48

Overview

Ulrik Gether is affiliated with the University of Copenhagen in Denmark. Their research spans multiple interconnected disciplines in life sciences, with a particular emphasis on neuroscience and molecular biology. Throughout their career, they have contributed extensively to understanding cellular and molecular mechanisms underlying neural processes.

Gether's main fields of study include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology

Their research encompasses significant subfields such as:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Cognitive Neuroscience
  • Cell Biology
  • Neurology

Among the prominent topics explored in their work are:

  • Receptor Mechanisms and Signaling
  • Neuroscience and Neuropharmacology Research
  • Neurotransmitter Receptor Influence on Behavior
  • Cellular transport and secretion
  • Neural dynamics and brain function
  • Lipid Membrane Structure and Behavior
  • Advanced Fluorescence Microscopy Techniques

Gether has published papers in leading scientific journals. Noteworthy recent publications include:

  • "Structural basis of organic cation transporter-3 inhibition," 2022, Nature Communications
  • "X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release," 2020, Nature Communications
  • "Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD," 2021, Psychopharmacology
  • "The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter," 2020, Nature Communications
  • "A high-affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain," 2020, EMBO Molecular Medicine

These publications reflect Gether's focus on molecular and structural aspects of transporter proteins and their role in neurological function and behavior.

Their work has appeared frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Reports
  • Journal of Biological Chemistry
  • Psychopharmacology

Gether's research collaborations involve several frequent co-authors, including:

  • Matthew D. Lycas
  • Freja Herborg
  • Aske L. Ejdrup
  • Andreas T. Sørensen
  • Kenneth L. Madsen

Throughout their career, Gether has been involved in advancing understanding of neural receptor function, transporter dynamics, and pharmacological modulation, contributing knowledge relevant for neurological and neuropsychiatric research.

Best Publications

  • Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

    Ulrik Gether

  • SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

    Anders S. Kristensen;Jacob Andersen;Trine N. Jørgensen;Lena Sørensen

  • G Protein-coupled Receptors II. MECHANISM OF AGONIST ACTIVATION

    Ulrik Gether;Brian K. Kobilka

  • Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

    Juan A. Ballesteros;Anne D. Jensen;George Liapakis;George Liapakis;Søren G.F. Rasmussen

  • Correlation between genetic and geographic structure in Europe.

    Oscar Lao;Timothy T. Lu;Michael Nothnagel;Olaf Junge

  • Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

    Pil Seok Chae;Søren G F Rasmussen;Rohini R. Rana;Kamil Gotfryd

  • Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor

    Ulrik Gether;Sansan Lin;Pejman Ghanouni;Juan A. Ballesteros

  • How curved membranes recruit amphipathic helices and protein anchoring motifs.

    Nikos S. Hatzakis;Vikram K. Bhatia;Jannik Larsen;Kenneth L. Madsen

  • [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist

    Jannie Fuhlendorff;Ulrik Gether;Lars Aakerlund;Nils Langeland-Johansen

  • The binding sites for cocaine and dopamine in the dopamine transporter overlap

    Thijs Beuming;Julie Kniazeff;Marianne L Bergmann;Lei Shi

  • Neurotransmitter transporters: molecular function of important drug targets

    Ulrik Gether;Peter H. Andersen;Orla M. Larsson;Arne Schousboe

  • Fluorescent Labeling of Purified β2 Adrenergic Receptor EVIDENCE FOR LIGAND-SPECIFIC CONFORMATIONAL CHANGES

    Ulrik Gether;Sansan Lin;Brian K. Kobilka

  • Structural Instability of a Constitutively Active G Protein-coupled Receptor AGONIST-INDEPENDENT ACTIVATION DUE TO CONFORMATIONAL FLEXIBILITY

    U Gether;J A Ballesteros;R Seifert;E Sanders-Bush

  • Mutation of a Highly Conserved Aspartic Acid in the β2 Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6

    Søren G.F. Rasmussen;Anne D. Jensen;George Liapakis;Pejman Ghanouni

  • Amphipathic motifs in BAR domains are essential for membrane curvature sensing

    Vikram K. Bhatia;Kenneth L. Madsen;Pierre-Yves Bolinger;Andreas Hjarne Kunding

  • Delineation of an endogenous zinc‐binding site in the human dopamine transporter

    Lene Norregaard;Dorte Frederiksen;Elsebet Ø. Nielsen;Ulrik Gether

  • Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-Induced Reverse Transport

    Jacob U. Fog;Habibeh Khoshbouei;Marion Holy;William A. Owens

  • Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

    U Gether;T E Johansen;R M Snider;J A Lowe rd

  • Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype

    Cecile Martinat;Jean-Jacques Bacci;Thomas Leete;Jongpil Kim

  • The solute carrier 6 family of transporters.

    Stefan Bröer;Ulrik Gether

Frequent Co-Authors

Brian K. Kobilka
Brian K. Kobilka Stanford University
Harel Weinstein
Harel Weinstein Cornell University
Thue W. Schwartz
Thue W. Schwartz University of Copenhagen
Jonathan A. Javitch
Jonathan A. Javitch Columbia University
Lars Vedel Kessing
Lars Vedel Kessing University of Copenhagen
Harald H. Sitte
Harald H. Sitte Medical University of Vienna
Lei Shi
Lei Shi National Institute on Drug Abuse
Maj Vinberg
Maj Vinberg University of Copenhagen
Amy Hauck Newman
Amy Hauck Newman National Institutes of Health
David P.D. Woldbye
David P.D. Woldbye University of Copenhagen

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