Jonathan A. Javitch

Overview

Best Publications

• Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

  Jonathan A. Javitch;Robert J. D'Amato;Stephen M. Strittmatter;Solomon H. Snyder

  1840
  Citations

• Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.

  Ellen Y. T. Chien;Wei Liu;Qiang Zhao;Vsevolod Katritch

  1340
  Citations

• Functional Selectivity and Classical Concepts of Quantitative Pharmacology

  Jonathan D. Urban;William P. Clarke;Mark Von Zastrow;David E. Nichols

  1317
  Citations

• Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

  Juan A. Ballesteros;Anne D. Jensen;George Liapakis;George Liapakis;Søren G.F. Rasmussen

  810
  Citations

• Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors.

  Juan A. Ballesteros;Lei Shi;Jonathan A. Javitch

  548
  Citations

• β2 Adrenergic Receptor Activation MODULATION OF THE PROLINE KINK IN TRANSMEMBRANE 6 BY A ROTAMER TOGGLE SWITCH

  Lei Shi;George Liapakis;Rui Xu;Frank Guarnieri

  503
  Citations

• Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.

  Christine Saunders;Jasmine V. Ferrer;Lei Shi;Jiayun Chen

  488
  Citations

• Building a new conceptual framework for receptor heteromers

  Sergi Ferré;Ruben Baler;Michel Bouvier;Marc G. Caron

  479
  Citations

• The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

  Lei Shi;Matthias Quick;Yongfang Zhao;Harel Weinstein

  442
  Citations

• Treatment resistant depression: A multi-scale, systems biology approach.

  Huda Akil;Joshua Gordon;Rene Hen;Jonathan Javitch

  441
  Citations

• The binding sites for cocaine and dopamine in the dopamine transporter overlap

  Thijs Beuming;Julie Kniazeff;Marianne L Bergmann;Lei Shi

  421
  Citations

• The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.

  Lei Shi;Jonathan A Javitch

  407
  Citations

• Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

  Yang Han;Irina S Moreira;Eneko Urizar;Harel Weinstein

  402
  Citations

• Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

  John A. Allen;Julianne M. Yost;Vincent Setola;Xin Chen

  398
  Citations

• Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

  Laura Albizu;Martin Cottet;Martin Cottet;Martin Cottet;Michaela Kralikova;Stoytcho Stoev

  394
  Citations

• Dopamine D2 receptors form higher order oligomers at physiological expression levels

  Wen Guo;Eneko Urizar;Michaela Kralikova;Juan Carlos Mobarec

  391
  Citations

• A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function.

  Thijs Beuming;Lei Shi;Jonathan A. Javitch;Harel Weinstein

  388
  Citations

• Amphetamine induces dopamine efflux through a dopamine transporter channel

  Kristopher M. Kahlig;Francesca Binda;Habibeh Khoshbouei;Randy D. Blakely

  384
  Citations

• Cyanine fluorophore derivatives with enhanced photostability

  Roger B Altman;Daniel S Terry;Zhou Zhou;Qinsi Zheng

  382
  Citations

• [3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites.

  J. A. Javitch;R. O. Blaustein;Solomon H Snyder

  374
  Citations

• Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

  Jonathan A. Javitch;Solomon H. Snyder

  363
  Citations