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Molecular Biology

D-Index
62
Citations
19321
World Ranking
1836
National Ranking
13

Overview

M. Prakash Hande is affiliated with the National University of Singapore in Singapore, where the research primarily focuses on the intersection of biochemistry, genetics, molecular biology, and medicine. Their body of work encompasses key subfields including molecular biology, physiology, cancer research, radiology, nuclear medicine and imaging, as well as pulmonary and respiratory medicine.

The scientist has contributed to research across several specialized topics:

  • DNA Repair Mechanisms
  • Telomeres, Telomerase, and Senescence
  • Carcinogens and Genotoxicity Assessment
  • Effects of Radiation Exposure
  • Radiation Therapy and Dosimetry
  • Epigenetics and DNA Methylation
  • Nuclear Structure and Function

The publication record reflects a significant engagement with the following venues, indicating the focus areas and dissemination channels:

  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis (8 publications)
  • International Journal of Radiation Biology (6 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Genome Integrity (4 publications)
  • Journal of Personalized Medicine (1 publication)

Several papers highlight recent contributions, including:

  • "Prediction of the Acute or Late Radiation Toxicity Effects in Radiotherapy Patients Using Ex Vivo Induced Biodosimetric Markers: A Review," published in 2020 in the Journal of Personalized Medicine
  • "Massively parallel single-molecule telomere length measurement with digital real-time PCR," published in 2020 in Science Advances
  • "DNA double-strand break-capturing nuclear envelope tubules drive DNA repair," published in 2024 in Nature Structural & Molecular Biology
  • "Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain," published in 2022 in GeroScience
  • "RENEB Inter-Laboratory comparison 2017: limits and pitfalls of ILCs," published in 2021 in International Journal of Radiation Biology

A number of frequent collaborators appear alongside M. Prakash Hande in various publications. These include:

  • Gavin Yong-Quan Ng
  • David Y. Fann
  • Karthik Mallilankaraman
  • Thiruma V. Arumugam
  • Grace Kah Mun Low

The research carried out by M. Prakash Hande covers 36 publications in biochemistry, genetics, and molecular biology, complemented by 27 publications related to medicine. The scientific output is marked by detailed investigations into molecular and cellular processes critical to understanding DNA damage and repair, cancer mechanisms, and the biological effects of radiation.

Best Publications

  • Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

    P. V. AshaRani;Grace Low Kah Mun;Manoor Prakash Hande;Suresh Valiyaveettil

  • Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

    María A. Blasco;María A. Blasco;Han Woong Lee;M. Prakash Hande;Enrique Samper

  • Anti-proliferative activity of silver nanoparticles

    PV AshaRani;M Prakash Hande;Suresh Valiyaveettil

  • Ku acts in a unique way at the mammalian telomere to prevent end joining

    Hsin Ling Hsu;David Gilley;Sanjeev A. Galande;M. Prakash Hande

  • Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

    M. Prakash Hande;Enrique Samper;Peter Lansdorp;María A. Blasco

  • Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

    F d'Adda di Fagagna;M P Hande;W M Tong;P M Lansdorp;P M Lansdorp

  • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

    Fabrizio d'Adda di Fagagna;M.Prakash Hande;Wei-Min Tong;David Roth

  • The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

    Y Liu;B.E Snow;M.P Hande;D Yeung;D Yeung

  • Health impact and safety of engineered nanomaterials

    Yiwei Teow;P V Asharani;M Prakash Hande;Suresh Valiyaveettil

  • Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy.

    Birendranath Banerjee;H.S. Vadiraj;Amritanshu Ram;Raghavendra Rao

  • hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells

    Inthrani R. Indran;Manoor P. Hande;Shazib Pervaiz

  • Oncogene‐induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

    Anitha Suram;Jessica Kaplunov;Priyanka L Patel;Haihe Ruan

  • Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster.

    Cheng Teng Ng;Liang Qing Yong;Manoor Prakash Hande;Choon Nam Ong

  • Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

    John Peter McPherson;Laura Tamblyn;Andrew Elia;Eva Migon

  • Involvement of mammalian Mus81 in genome integrity and tumor suppression.

    John Peter McPherson;John Peter McPherson;Bénédicte Lemmers;Bénédicte Lemmers;Richard Chahwan;Richard Chahwan;Ashwin Pamidi;Ashwin Pamidi

  • DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

    P V Asharani;Ng Xinyi;M Prakash Hande;Suresh Valiyaveettil

  • DNA-PKcs is critical for telomere capping.

    David Gilley;Hiromi Tanaka;Hiromi Tanaka;M. Prakash Hande;Akihiro Kurimasa;Akihiro Kurimasa

  • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.

    Hiroyuki Niida;Yuko Katsuno;Birendranath Banerjee;M. Prakash Hande

  • Prediction of the Acute or Late Radiation Toxicity Effects in Radiotherapy Patients Using Ex Vivo Induced Biodosimetric Markers: A Review

    Volodymyr Vinnikov;Manoor Prakash Hande;Ruth Wilkins;Andrzej Wojcik

  • Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

    Resham Lal Gurung;Shi Ni Lim;Aik Kia Khaw;Jasmine Fen Fen Soon

Frequent Co-Authors

Razqallah Hakem
Razqallah Hakem University of Toronto
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Suresh Valiyaveettil
Suresh Valiyaveettil National University of Singapore
Adayapalam T. Natarajan
Adayapalam T. Natarajan Leiden University
Jeremy A. Squire
Jeremy A. Squire Universidade de São Paulo
Shizuo Akira
Shizuo Akira Osaka University
Fabrizio d'Adda di Fagagna
Fabrizio d'Adda di Fagagna University of Cambridge
Thiruma V. Arumugam
Thiruma V. Arumugam La Trobe University
David J. Brenner
David J. Brenner Columbia University
Chwee Teck Lim
Chwee Teck Lim National University of Singapore

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