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Genetics

D-Index
60
Citations
20178
World Ranking
3119
National Ranking
1362

Overview

Sandy Chang is affiliated with Yale University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant number of publications in these areas. The scientist's work spans major subfields such as molecular biology, physiology, surgery, and oncology.

The core topics covered in their research include telomeres, telomerase, and senescence; DNA repair mechanisms; CRISPR and genetic engineering; nuclear structure and function; genomics and chromatin dynamics; advanced biosensing and bioanalysis techniques; and RNA interference and gene delivery.

Frequent publication venues for Sandy Chang include:

  • Nature Communications
  • Nucleic Acids Research
  • Current Opinion in Genetics & Development
  • BioEssays
  • Journal of Clinical Oncology

Some of the recent papers by Sandy Chang are:

  • "Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres" (2021, Nature Communications)
  • "Shelterin and the replisome: at the intersection of telomere repair and replication" (2020, Current Opinion in Genetics & Development)
  • "Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly" (2020, Nature Communications)
  • "Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1" (2023, Nature Communications)
  • "Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation" (2023, Nucleic Acids Research)

The scientist has collaborated frequently with several coauthors, most notably:

  • Rekha Rai
  • Yong Chen
  • Tori Sodeinde
  • Wenqi Sun
  • Amer Al-Hiyasat

Their research exhibits a consistent focus on telomere biology, specifically exploring the mechanisms of telomerase regulation, telomere replication, repair, and associated cellular processes. Investigations also address the connection between telomere dysfunction and diseases such as primary microcephaly and tumor progression. Through their body of work, they contribute to a deeper understanding of DNA repair, genome stability, and cellular aging.

Best Publications

  • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

    Sunil R. Hingorani;Lifu Wang;Asha S. Multani;Chelsea Combs

  • Longevity, stress response, and cancer in aging telomerase-deficient mice.

    Karl Lenhard Rudolph;Sandy Chang;Han Woong Lee;Maria Blasco

  • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

    Steven E. Artandi;Sandy Chang;Sandy Chang;Shwu-Luan Lee;Scott Alson

  • Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

    David A Tuveson;Alice T Shaw;Alice T Shaw;Alice T Shaw;Nicholas A Willis;Daniel P Silver

  • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.

    Karl Lenhard Rudolph;Sandy Chang;Melissa Millard;Nicole Schreiber-Agus

  • Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I.

    D S Geller;J Rodriguez-Soriano;A Vallo Boado;S Schifter

  • Essential role of limiting telomeres in the pathogenesis of Werner syndrome.

    Sandy Chang;Asha S Multani;Noelia G Cabrera;Maria L Naylor

  • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.

    David O. Ferguson;JoAnn M. Sekiguchi;Sandy Chang;Karen M. Frank

  • Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.

    Ling Wu;Asha S. Multani;Hua He;Wilfredo Cosme-Blanco

  • Telomere dysfunction and tumour suppression: the senescence connection

    Yibin Deng;Suzanne S. Chan;Sandy Chang

  • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.

    Geng Liu;John M Parant;Gene Lang;Patty Chau

  • TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

    Rachel Litman Flynn;Richard C. Centore;Roderick J. O’Sullivan;Rekha Rai

  • Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.

    Kwok Kin Wong;Sandy Chang;Sarah R. Weiler;Shridar Ganesan

  • Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

    Jeffrey Buis;Yipin Wu;Yibin Deng;Jennifer Leddon

  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

    Edmond M Chan;Edmond M Chan;Tsukasa Shibue;James M McFarland;Benjamin Gaeta

  • Telomere dysfunction provokes regional amplification and deletion in cancer genomes

    Rónán C O'Hagan;Sandy Chang;Richard S Maser;Ramya Mohan

  • Prelamin A and lamin A appear to be dispensable in the nuclear lamina

    Loren G. Fong;Jennifer K. Ng;Jan Lammerding;Timothy A. Vickers

  • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

    Wilfredo Cosme-Blanco;Mei Feng Shen;Alexander J.F. Lazar;Sen Pathak

  • Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.

    Catherine Coffinier;Hea-Jin Jung;Chika Nobumori;Sandy Chang

  • Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.

    Xiaolan Guo;Yibin Deng;Yahong Lin;Wilfredo Cosme-Blanco

Frequent Co-Authors

Asha S. Multani
Asha S. Multani The University of Texas MD Anderson Cancer Center
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Sen Pathak
Sen Pathak The University of Texas MD Anderson Cancer Center
Linda P. Fried
Linda P. Fried Columbia University
Mary E. Tinetti
Mary E. Tinetti Yale University
Todd R. Golub
Todd R. Golub Harvard University
Steven E. Artandi
Steven E. Artandi Stanford University
Alice T. Shaw
Alice T. Shaw Harvard University
Lynda Chin
Lynda Chin The University of Texas Health Science Center at Houston
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine

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