What is he best known for?
The fields of study he is best known for:
The scientist’s investigation covers issues in Telomere, Telomerase, Genetics, Carcinogenesis and Cancer research.
His work deals with themes such as Shelterin, Telomere-binding protein, DNA damage, Molecular biology and Cell biology, which intersect with Telomere.
His work carried out in the field of Telomerase brings together such families of science as Liver function, Cirrhosis and Endocrinology, Ratón.
His Cancer research study incorporates themes from Tumor suppressor gene and Senescence.
His studies in Tumor suppressor gene integrate themes in fields like Gene expression, Chromosomal translocation, KRAS and Metastatic carcinoma, Carcinoma.
His Genome instability research integrates issues from Telomerase RNA component and DNA repair.
His most cited work include:
- Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice (1543 citations)
- Longevity, stress response, and cancer in aging telomerase-deficient mice. (1161 citations)
- Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice (952 citations)
What are the main themes of his work throughout his whole career to date?
Sandy Chang spends much of his time researching Telomere, Genetics, DNA damage, Telomerase and Cell biology.
The Telomere study combines topics in areas such as Telomere-binding protein, Shelterin, Cancer research, Genome instability and Molecular biology.
He has included themes like Low Molecular Weight Cyclin E, Carcinogenesis, Tumor suppressor gene, Cyclin E and KRAS in his Cancer research study.
In his work, Gene expression is strongly intertwined with Chromosomal translocation, which is a subfield of Tumor suppressor gene.
His study in the field of Cancer, Chromosome, Telomere dysfunction and Genome stability is also linked to topics like Context.
Sandy Chang interconnects Cancer cell, Tumor progression, Cell culture and DNA polymerase in the investigation of issues within Telomerase.
He most often published in these fields:
- Telomere (73.20%)
- Genetics (39.18%)
- DNA damage (35.05%)
What were the highlights of his more recent work (between 2015-2021)?
- Telomere (73.20%)
- Cell biology (26.80%)
- DNA repair (19.59%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Telomere, Cell biology, DNA repair, Genetics and Telomere-binding protein.
His biological study spans a wide range of topics, including Shelterin, DNA damage, Mutation, Senescence and Telomerase.
His studies deal with areas such as Carcinogenesis, G2-M DNA damage checkpoint and Binding site as well as DNA damage.
His Telomerase study combines topics from a wide range of disciplines, such as DNA, Mutant and Cas9.
His Cell biology research includes elements of Protein structure and Repeated sequence.
His Genetics research is mostly focused on the topic Genome instability.
Between 2015 and 2021, his most popular works were:
- WRN helicase is a synthetic lethal target in microsatellite unstable cancers. (87 citations)
- TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions (61 citations)
- Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. (41 citations)
In his most recent research, the most cited papers focused on:
His main research concerns DNA repair, Telomere, Telomere-binding protein, Homologous recombination and Genome instability.
Much of his study explores DNA repair relationship to Gene silencing.
Sandy Chang has researched Telomere in several fields, including Nucleoprotein, Homology, Protein structure, Repeated sequence and Cell biology.
His Telomere-binding protein research is multidisciplinary, incorporating perspectives in Plasma protein binding and Telomere end protection.
His Homologous recombination research incorporates elements of Cancer research, Polymerase and DNA mismatch repair.
His Genome instability research is included under the broader classification of Genetics.
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