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Biology and Biochemistry

D-Index
71
Citations
17043
World Ranking
6693
National Ranking
163

Overview

Paul Timpson is affiliated with the Garvan Institute of Medical Research in Australia and is active in the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields including molecular biology, oncology, cancer research, cell biology, and immunology.

Their work covers a broad range of main topics such as pancreatic and hepatic oncology research, cancer cells and metastasis, cellular mechanics and interactions, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, extracellular vesicles in disease, and microRNA in disease regulation.

Recent notable papers include:

  • Stromal cell diversity associated with immune evasion in human triple-negative breast cancer, 2020, The EMBO Journal
  • Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption, 2021, Cell
  • Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis, 2022, Nature Communications
  • Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis, 2021, Nature Communications
  • Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress, 2020, Nature Cell Biology

Frequent co-authors in their research collaborations are:

  • David Herrmann
  • Max Nobis
  • Kendelle J. Murphy
  • Brooke Pereira
  • Thomas R. Cox

Their publications are often found in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Science Advances
  • Nature Communications

Best Publications

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

    Jennifer P. Morton;Paul Timpson;Saadia A. Karim;Rachel A. Ridgway

  • Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

    Michael S. Samuel;Jose I. Lopez;Ewan J. McGhee;Daniel R. Croft

  • Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

    Graeme I. Lancaster;Graeme I. Lancaster;Katherine G. Langley;Katherine G. Langley;Nils Anton Berglund;Helene L. Kammoun

  • FAK signaling in human cancer as a target for therapeutics

    Brian Y. Lee;Paul Timpson;Lisa G. Horvath;Roger J. Daly;Roger J. Daly

  • ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

    Kevin B. Myant;Patrizia Cammareri;Ewan J. McGhee;Rachel A. Ridgway

  • Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

    Michelle M. McDonald;Michelle M. McDonald;Weng Hua Khoo;Weng Hua Khoo;Pei Ying Ng;Ya Xiao

  • Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

    Aurélie S. Cazet;Aurélie S. Cazet;Mun N. Hui;Benjamin L. Elsworth;Sunny Z. Wu;Sunny Z. Wu

  • Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression

    Marta A. Dozynkiewicz;Nigel B. Jamieson;Nigel B. Jamieson;Iain MacPherson;Joan Grindlay

  • A role for the actin cytoskeleton in cell death and aging in yeast

    Campbell W. Gourlay;Lindsay N. Carpp;Paul Timpson;Steven J. Winder

  • Stromal cell diversity associated with immune evasion in human triple-negative breast cancer.

    Sunny Z. Wu;Sunny Z. Wu;Daniel L. Roden;Daniel L. Roden;Chenfei Wang;Holly Holliday;Holly Holliday

  • Fluids and their mechanics in tumour transit: shaping metastasis

    Gautier Follain;Gautier Follain;David Herrmann;David Herrmann;Sébastien Harlepp;Sébastien Harlepp;Vincent Hyenne

  • Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

    Claire Vennin;Claire Vennin;Venessa T. Chin;Venessa T. Chin;Sean C. Warren;Sean C. Warren;Morghan C. Lucas;Morghan C. Lucas

  • Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

    Bryan W Miller;Jennifer P Morton;Mark Pinese;Grazia Saturno

  • Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity.

    Paul Timpson;Gareth E. Jones;Margaret C. Frame;Valerie G. Brunton

  • CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer.

    Brooke A. Pereira;Claire Vennin;Michael Papanicolaou;Cecilia R. Chambers;Cecilia R. Chambers

  • CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

    Claire Vennin;Claire Vennin;Claire Vennin;Pauline Mélénec;Pauline Mélénec;Romain Rouet;Romain Rouet;Max Nobis;Max Nobis

  • Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

    P A J Muller;A G Trinidad;P Timpson;J P Morton

  • Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

    Claire Vennin;Kendelle J. Murphy;Kendelle J. Murphy;Jennifer P. Morton;Thomas R. Cox;Thomas R. Cox

  • N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

    Xinzi Yu;Tobias Zech;Laura McDonald;Esther Garcia Gonzalez

Frequent Co-Authors

Marina Pajic
Marina Pajic Garvan Institute of Medical Research
Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Owen J. Sansom
Owen J. Sansom University of Glasgow
Anthony J. Gill
Anthony J. Gill University of Sydney
Andrew V. Biankin
Andrew V. Biankin University of Glasgow
Alexander Swarbrick
Alexander Swarbrick Garvan Institute of Medical Research
Roger J. Daly
Roger J. Daly Monash University
Valerie G. Brunton
Valerie G. Brunton University of Edinburgh
Margaret C. Frame
Margaret C. Frame University of Edinburgh

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