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Biology and Biochemistry

D-Index
86
Citations
27411
World Ranking
2954
National Ranking
219

Research.com Recognitions

  • 2003 - Fellow of the Royal Society of Edinburgh

Overview

Margaret C. Frame is affiliated with the University of Edinburgh in the United Kingdom, where their research primarily spans fields including Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work involves a significant focus on Molecular Biology, Immunology, Cell Biology, Genetics, and related disciplines.

The scientist has contributed to research on multiple topics, including:

  • Cell Adhesion Molecules Research
  • Cellular Mechanics and Interactions
  • Glioma Diagnosis and Treatment
  • Immune cells in cancer
  • RNA Research and Splicing
  • Cancer Genomics and Diagnostics
  • Ubiquitin and proteasome pathways

The research output includes papers such as:

  • Targeting FAK in anticancer combination therapies, 2021, Nature reviews. Cancer
  • Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion, 2021, Cell
  • Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer, 2020, Gastroenterology
  • The intrinsic substrate specificity of the human tyrosine kinome, 2024, Nature
  • Structural basis of Focal Adhesion Kinase activation on lipid membranes, 2020, The EMBO Journal

Frequent collaborators include Valerie G. Brunton, Neil O. Carragher, John C. Dawson, Adam Byron, and Morwenna Muir.

Publications by Margaret C. Frame have appeared in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Neuro-Oncology
  • Cancer Research
  • Scientific Reports

Margaret C. Frame was awarded the Fellow of the Royal Society of Edinburgh in 2003.

Best Publications

  • The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.

    D. J. McGeoch;M. A. Dalrymple;A. J. Davison;A. Dolan

  • The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

    Gordon W. McLean;Neil O. Carragher;Egle Avizienyte;Jeff Evans

  • Src in cancer: deregulation and consequences for cell behaviour.

    Margaret C. Frame

  • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

    Jennifer P. Morton;Paul Timpson;Saadia A. Karim;Rachel A. Ridgway

  • E-cadherin-integrin crosstalk in cancer invasion and metastasis.

    Marta Canel;Alan Serrels;Margaret C. Frame;Valerie G. Brunton

  • Newest findings on the oldest oncogene; how activated src does it.

    Margaret C. Frame

  • Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src.

    V J Fincham;M James;M James;Margaret Frame;Stephanie Winder;Stephanie Winder

  • Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

    Egle Avizienyte;Anne W. Wyke;Robert J. Jones;Gordon W. McLean

  • A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

    Chris M. Preston;Margaret C. Frame;Moyra E.M. Campbell

  • The calpain system and cancer

    Sarah J. Storr;Neil O. Carragher;Margaret C. Frame;Tim Parr

  • Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI.

    D C Johnson;M C Frame;M W Ligas;A M Cross

  • Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

    Neil O. Carragher;Margaret C. Frame

  • Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

    Alan Serrels;Tom Lund;Bryan Serrels;Adam Byron

  • The FERM domain: organizing the structure and function of FAK

    Margaret C. Frame;Hitesh Patel;Bryan Serrels;Daniel Lietha

  • The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

    V J Fincham;Margaret Frame

  • v-Src's hold over actin and cell adhesions.

    Margaret C Frame;Valerie J Fincham;Neil O Carragher;John A Wyke

  • Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

    Egle Avizienyte;Margaret C Frame

  • RhoB and Actin Polymerization Coordinate Src Activation with Endosome-Mediated Delivery to the Membrane

    Emma Sandilands;Christophe Cans;Valerie J. Fincham;Valerie G. Brunton

  • Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

    M Agochiya;V G Brunton;D W Owens;E K Parkinson

  • Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

    Bryan Serrels;Alan Serrels;Valerie G. Brunton;Mark Holt

Frequent Co-Authors

Valerie G. Brunton
Valerie G. Brunton University of Edinburgh
Owen J. Sansom
Owen J. Sansom University of Glasgow
Duncan J. McGeoch
Duncan J. McGeoch University of Glasgow
Paul Timpson
Paul Timpson Garvan Institute of Medical Research
Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Paul Lorigan
Paul Lorigan University of Manchester
George S. Baillie
George S. Baillie University of Glasgow
Miles D. Houslay
Miles D. Houslay King's College London

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