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Biology and Biochemistry

D-Index
75
Citations
18753
World Ranking
5359
National Ranking
415

Overview

George S. Baillie is affiliated with the University of Glasgow in the United Kingdom and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans multiple subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Pharmacology, Oncology, and Infectious Diseases.

Their main research topics reflect a focus on cellular signaling and biochemical regulation, including:

  • Phosphodiesterase function and regulation
  • Receptor Mechanisms and Signaling
  • Cholinesterase and Neurodegenerative Diseases
  • Renin-Angiotensin System Studies
  • Cardiomyopathy and Myosin Studies
  • Peptidase Inhibition and Analysis
  • Ion Transport and Channel Regulation

Baillie's publication record features notable papers such as:

  • Phosphodiesterase 4B: Master Regulator of Brain Signaling (2020, Cells)
  • Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP (2020, Cell Reports)
  • The Enigmatic Helicase DHX9 and Its Association With the Hallmarks of Cancer (2020, Future Science OA)
  • Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalization (2021, Peptide Science)
  • Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins (2022, Journal of Molecular and Cellular Cardiology)

Frequent publication venues for Baillie include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • FEBS Journal
  • Cellular Signalling
  • The International Journal of Biochemistry & Cell Biology

Baillie collaborates often with several co-authors, including:

  • Connor M. Blair
  • William Fuller
  • Ralf Hoffmann
  • Jiayue Ling
  • Yuan Yan Sin

Best Publications

  • DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.

    J. Kirsty Millar;Benjamin S. Pickard;Shaun Mackie;Rachel James

  • Targeting of Cyclic AMP Degradation to β2-Adrenergic Receptors by β-Arrestins

    Stephen J. Perry;George S. Baillie;Trudy A. Kohout;Ian McPhee

  • Sleep deprivation impairs cAMP signalling in the hippocampus

    Christopher G. Vecsey;George S. Baillie;Devan Jaganath;Robbert Havekes

  • Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents

    G S Baillie;L J Douglas

  • Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.

    Schafer Ph;Parton A;Gandhi Ak;Capone L

  • Mixed species biofilms of Candida albicans and Staphylococcus epidermidis.

    Berit Adam;George S. Baillie;L. Julia Douglas

  • β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

    George S. Baillie;Arvind Sood;Ian McPhee;Irene Gall

  • Role of dimorphism in the development of Candida albicans biofilms.

    George S. Baillie;L. Julia Douglas

  • cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.

    Miles D. Houslay;George S. Baillie;Donald H. Maurice

  • ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.

    Simon J. MacKenzie;George S. Baillie;Ian McPhee;Graeme B. Bolger

  • Effect of Growth Rate on Resistance of Candida albicans Biofilms to Antifungal Agents

    George S. Baillie;L. Julia Douglas

  • The MAP kinase ERK2 inhibits the cyclic AMP‐specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579

    Ralf Hoffmann;George S. Baillie;Simon J. MacKenzie;Stephen Yarwood

  • RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells *

    Martin J. Lynch;George S. Baillie;Ahmed Mohamed;Xiang Li

  • Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.

    George S. Baillie;Gonzalo S. Tejeda;Michy P. Kelly

  • Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

    Simon J MacKenzie;George S Baillie;Ian McPhee;Carolynn MacKenzie

  • Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

    Robbert Havekes;Robbert Havekes;Alan J Park;Jennifer C Tudor;Vincent G Luczak

  • Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

    George S. Baillie

  • Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

    George S. Baillie;John D. Scott;Miles D. Houslay

  • Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

    Giulietta Di Benedetto;Anna Zoccarato;Valentina Lissandron;Anna Terrin

  • Production of extracellular matrix by Candida albicans biofilms.

    Hawser Sp;Baillie Gs;Douglas Lj

Frequent Co-Authors

Miles D. Houslay
Miles D. Houslay King's College London
Enno Klussmann
Enno Klussmann Max Delbrück Center for Molecular Medicine
Robbert Havekes
Robbert Havekes University of Groningen
Graeme Milligan
Graeme Milligan University of Glasgow
Manuela Zaccolo
Manuela Zaccolo University of Oxford
Rhian M. Touyz
Rhian M. Touyz McGill University Health Centre
Ted Abel
Ted Abel University of Iowa
Peter Meerlo
Peter Meerlo University of Groningen
Rosemary O'Connor
Rosemary O'Connor University College Cork
Stefano Marullo
Stefano Marullo Université Paris Cité

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