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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
110
Citations
40545
World Ranking
975
National Ranking
53

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 1986 - Fellow of the Royal Society of Edinburgh

Overview

Miles D. Houslay is affiliated with King's College London in the United Kingdom, with a focus on research spanning biochemistry, genetics, molecular biology, and medicine. Their work primarily addresses molecular biology, with additional contributions to cardiology and cardiovascular medicine, organic chemistry, physiology, and cellular and molecular neuroscience.

The main topics of research undertaken by Houslay include phosphodiesterase function and regulation, receptor mechanisms and signaling, synthesis and catalytic reactions, neurotransmitter receptor influence on behavior, synthesis and biological activity, bipolar disorder and treatment, and biomedical research and pathophysiology.

Frequent publication venues for Houslay's work include the Journal of the American Society of Nephrology, Journal of Biological Chemistry, Molecular Psychiatry, UNC Libraries, and Molecular and Cellular Biology.

  • George S. Baillie
  • Koko Ishizuka
  • David Henderson
  • Xiaofang Wang
  • Julia M. Adam

Notable recent papers authored by or associated with Houslay include:

  • Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit, 2022, Molecular Psychiatry
  • Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors, 2020, UNC Libraries
  • Small-Molecule Allosteric Activators of Long-Form PDE4 Enzymes Suppress Cystogenesis in Models of ADPKD, 2020, Journal of the American Society of Nephrology
  • Withdrawal: Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5, 2020, Journal of Biological Chemistry
  • Correction for Bjørgo et al., "Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex", 2022, Molecular and Cellular Biology

Houslay was awarded the fellowship of the Royal Society of Edinburgh in 1986.

Best Publications

  • PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.

    Miles D Houslay;David R Adams

  • Keynote review: Phosphodiesterase-4 as a therapeutic target

    Miles D. Houslay;Peter Schafer;Kam Y.J. Zhang

  • DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.

    J. Kirsty Millar;Benjamin S. Pickard;Shaun Mackie;Rachel James

  • Targeting of Cyclic AMP Degradation to β2-Adrenergic Receptors by β-Arrestins

    Stephen J. Perry;George S. Baillie;Trudy A. Kohout;Ian McPhee

  • Behavioral phenotypes of Disc1 missense mutations in mice.

    Steven J. Clapcote;Tatiana V. Lipina;J. Kirsty Millar;Shaun Mackie

  • mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

    Kimberly L. Dodge;Samone Khouangsathiene;Michael S. Kapiloff;Robert Mouton

  • Tailoring cAMP-signalling responses through isoform multiplicity

    Miles D. Houslay;Graeme Milligan

  • Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

    Miles D. Houslay

  • Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

    Marco Mongillo;Theresa McSorley;Sandrine Evellin;Arvind Sood

  • Sleep deprivation impairs cAMP signalling in the hippocampus

    Christopher G. Vecsey;George S. Baillie;Devan Jaganath;Robbert Havekes

  • Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein

    G. B. Warren;M. D. Houslay;J. C. Metcalfe;N. J. M. Birdsall

  • Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

    Akiko Hayashi-Takagi;Manabu Takaki;Nick Graziane;Saurav Seshadri

  • The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms

    Angela McCahill;Jim Warwicker;Graeme B. Bolger;Miles D. Houslay

  • Activation of two signal-transduction systems in hepatocytes by glucagon

    Michael J. O. Wakelam;Gregory J. Murphy;Victor J. Hruby;Miles D. Houslay

  • Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.

    Michael J. O. Wakelam;Shireen A. Davies;Miles D. Houslay;Ian McKay

  • 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways.

    Miles D. Houslay

  • β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

    George S. Baillie;Arvind Sood;Ian McPhee;Irene Gall

  • Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin.

    T. R. Hesketh;G. A. Smith;M. D. Houslay;K. A. McGill

  • A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

    Dawn M. Juilfs;Hans-Jürgen Fülle;Allan Z. Zhao;Miles D. Houslay

  • The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions

    Miles D. Houslay;Michael Sullivan;Graeme B. Bolger

Frequent Co-Authors

George S. Baillie
George S. Baillie University of Glasgow
Graeme Milligan
Graeme Milligan University of Glasgow
Nigel J. Pyne
Nigel J. Pyne University of Strathclyde
Enno Klussmann
Enno Klussmann Max Delbrück Center for Molecular Medicine
Michael J. O. Wakelam
Michael J. O. Wakelam Babraham Institute
Anthony D. Whetton
Anthony D. Whetton University of Manchester
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Shireen A. Davies
Shireen A. Davies University of Glasgow
Akira Sawa
Akira Sawa Johns Hopkins University
David J. Porteous
David J. Porteous University of Edinburgh

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