1986 - Fellow of the Royal Society of Edinburgh
Miles D. Houslay mainly investigates Biochemistry, Phosphodiesterase, Cell biology, Protein kinase A and Signal transduction. His research in Phosphodiesterase intersects with topics in Molecular biology, Kinase, Intracellular and Gene isoform. His Cell biology research is multidisciplinary, incorporating perspectives in Receptor, Cell type and Flux.
His Receptor research includes themes of Endocrinology and Glucagon. Miles D. Houslay works mostly in the field of Protein kinase A, limiting it down to concerns involving Rolipram and, occasionally, Mutant. Miles D. Houslay has researched Signal transduction in several fields, including Plasma protein binding, Neuroscience and Signalling.
Miles D. Houslay mostly deals with Phosphodiesterase, Biochemistry, Cell biology, Internal medicine and Endocrinology. His work deals with themes such as Molecular biology, Intracellular, Protein kinase A and Gene isoform, which intersect with Phosphodiesterase. In his study, Adenylyl cyclase is inextricably linked to Forskolin, which falls within the broad field of Molecular biology.
His studies in Protein kinase A integrate themes in fields like Beta-Arrestins and MAPK/ERK pathway. His study in Endocrinology is interdisciplinary in nature, drawing from both Adenylate kinase and G protein. His studies deal with areas such as Glucagon receptor and Glucagon as well as Adenylate kinase.
His scientific interests lie mostly in Phosphodiesterase, Cell biology, Protein kinase A, Phosphorylation and Neuroscience. His Phosphodiesterase research incorporates elements of Cancer research, Molecular biology, Internal medicine, Intracellular and Gene isoform. When carried out as part of a general Cell biology research project, his work on Scaffold protein, Phosphodiesterase 3, Kinase and RHOA is frequently linked to work in Low-affinity nerve growth factor receptor, therefore connecting diverse disciplines of study.
His Protein kinase A study incorporates themes from Endocrinology and Receptor, Signal transduction, Activator, Second messenger system. His Phosphorylation study necessitates a more in-depth grasp of Biochemistry. In most of his Biochemistry studies, his work intersects topics such as Biophysics.
Miles D. Houslay mainly focuses on Cell biology, Protein kinase A, Signal transduction, Phosphodiesterase and Phosphorylation. His Effector, Scaffold protein and Kinase study, which is part of a larger body of work in Cell biology, is frequently linked to Vascular endothelial growth factor A, bridging the gap between disciplines. His work carried out in the field of Protein kinase A brings together such families of science as Myocyte, Endocrinology, Enzyme activator and Second messenger system.
Miles D. Houslay focuses mostly in the field of Endocrinology, narrowing it down to matters related to PRKAR1A and, in some cases, Internal medicine. His Signal transduction study improves the overall literature in Biochemistry. The Phosphodiesterase study combines topics in areas such as Molecular biology, Peptide and Prostate cancer, Androgen receptor.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
Miles D Houslay;David R Adams.
Biochemical Journal (2003)
Keynote review: Phosphodiesterase-4 as a therapeutic target
Miles D. Houslay;Peter Schafer;Kam Y.J. Zhang.
Drug Discovery Today (2005)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
J. Kirsty Millar;Benjamin S. Pickard;Shaun Mackie;Rachel James.
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Stephen J. Perry;George S. Baillie;Trudy A. Kohout;Ian McPhee.
Behavioral phenotypes of Disc1 missense mutations in mice.
Steven J. Clapcote;Tatiana V. Lipina;J. Kirsty Millar;Shaun Mackie.
Tailoring cAMP-signalling responses through isoform multiplicity
Miles D. Houslay;Graeme Milligan.
Trends in Biochemical Sciences (1997)
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
Kimberly L. Dodge;Samone Khouangsathiene;Michael S. Kapiloff;Robert Mouton.
The EMBO Journal (2001)
Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein
G. B. Warren;M. D. Houslay;J. C. Metcalfe;N. J. M. Birdsall.
Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases
Marco Mongillo;Theresa McSorley;Sandrine Evellin;Arvind Sood.
Circulation Research (2004)
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
Miles D. Houslay.
Trends in Biochemical Sciences (2010)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: