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Biology and Biochemistry

D-Index
59
Citations
13319
World Ranking
12473
National Ranking
966

Overview

Manuela Zaccolo is affiliated with the University of Oxford in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with notable contributions to Medicine. Subfields of focus include Molecular Biology, Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Physiology, and Pharmacology.

The scientist's research work encompasses several main topics, including:

  • Phosphodiesterase function and regulation
  • Receptor Mechanisms and Signaling
  • Cardiac electrophysiology and arrhythmias
  • Neuropeptides and Animal Physiology
  • Cholinesterase and Neurodegenerative Diseases
  • Ion channel regulation and function
  • Calcium signaling and nucleotide metabolism

Frequent publication venues for Manuela Zaccolo include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cardiovascular Research
  • Pharmacological Reviews
  • American Journal of Physiology-Heart and Circulatory Physiology
  • Circulation

Among the recent papers authored or coauthored by this scientist are:

  • Subcellular Organization of the cAMP Signaling Pathway (2020, Pharmacological Reviews)
  • Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling (2022, Cell)
  • Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients (2020, Scientific Reports)
  • G Protein-Coupled Receptor Signaling: New Insights Define Cellular Nanodomains (2023, The Annual Review of Pharmacology and Toxicology)
  • IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases (2020, American Journal of Physiology-Heart and Circulatory Physiology)

Manuela Zaccolo has collaborated frequently with several coauthors, including:

  • Andreas Koschinski
  • Milda Folkmanaite
  • Rebecca A. Capel
  • Samuel J. Bose
  • Rebecca A.B. Burton

The scientist also has a book publication titled cAMP Signaling, published by Springer Science+Business Media in 2022.

Best Publications

  • Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.

    Manuela Zaccolo;Tullio Pozzan

  • A genetically encoded, fluorescent indicator for cyclic AMP in living cells.

    M Zaccolo;F De Giorgi;C Y Cho;L Feng

  • Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

    Marco Mongillo;Theresa McSorley;Sandrine Evellin;Arvind Sood

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • An Approach to Random Mutagenesis of DNA Using Mixtures of Triphosphate Derivatives of Nucleoside Analogues

    Manuela Zaccolo;David M. Williams;Daniel M. Brown;Ermanno Gherardi

  • cAMP and cGMP Signaling Cross-Talk: Role of Phosphodiesterases and Implications for Cardiac Pathophysiology

    Manuela Zaccolo;Matthew A. Movsesian

  • Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

    Marco Mongillo;Carlo G. Tocchetti;Anna Terrin;Valentina Lissandron

  • Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation.

    A Funaro;G C Spagnoli;C M Ausiello;M Alessio

  • The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase.

    Manuela Zaccolo;Ermanno Gherardi

  • cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism

    Eiki Takimoto;Hunter C. Champion;Diego Belardi;Javid Moslehi

  • Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling

    Carlo G. Tocchetti;Wang Wang;Jeffrey P. Froehlich;Sabine Huke

  • AKAP complex regulates Ca2+ re‐uptake into heart sarcoplasmic reticulum

    Birgitte Lygren;Cathrine Rein Carlson;Katja Santamaria;Valentina Lissandron

  • Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.

    Chunying Li;Partha C. Krishnamurthy;Himabindu Penmatsa;Kevin L. Marrs

  • Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

    Giulietta Di Benedetto;Anna Zoccarato;Valentina Lissandron;Anna Terrin

  • cAMP signaling in subcellular compartments

    Konstantinos Lefkimmiatis;Manuela Zaccolo

  • PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

    Anna Terrin;Giulietta Di Benedetto;Vanessa Pertegato;York-Fong Cheung

  • Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

    József Maléth;Anita Balázs;Petra Pallagi;Zsolt Balla

  • cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

    Manuela Zaccolo

  • Subcellular Organization of the cAMP Signaling Pathway.

    Manuela Zaccolo;Anna Zerio;Miguel J. Lobo

  • FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

    Nicoletta C. Surdo;Marco Berrera;Andreas Koschinski;Marcella Brescia

Frequent Co-Authors

Tullio Pozzan
Tullio Pozzan University of Padua
George S. Baillie
George S. Baillie University of Glasgow
Fabio Malavasi
Fabio Malavasi University of Turin
Miles D. Houslay
Miles D. Houslay King's College London
Viacheslav O. Nikolaev
Viacheslav O. Nikolaev Universität Hamburg
Keith M. Channon
Keith M. Channon University of Oxford
Martina Schmidt
Martina Schmidt Johannes Gutenberg University of Mainz
Barbara Casadei
Barbara Casadei University of Oxford
David A. Kass
David A. Kass Johns Hopkins University School of Medicine
Ermanno Gherardi
Ermanno Gherardi University of Pavia

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