Manuela Zaccolo mainly focuses on Cell biology, Signal transduction, Protein kinase A, Phosphodiesterase and Biochemistry. Her Cell biology study incorporates themes from T cell and Cytokine. Her Signal transduction study integrates concerns from other disciplines, such as Stimulus, Receptor, Cell division and Drug discovery.
Her Protein kinase A research is multidisciplinary, incorporating elements of CD28, T cell cytokine production, Endoplasmic reticulum and Immune system. Manuela Zaccolo combines subjects such as Myocyte and Gene isoform with her study of Phosphodiesterase. Her Biochemistry study deals with Förster resonance energy transfer intersecting with Green fluorescent protein, Kinase and Agonist.
Her primary areas of investigation include Cell biology, Protein kinase A, Phosphodiesterase, Signal transduction and Förster resonance energy transfer. In Cell biology, Manuela Zaccolo works on issues like Cyclic adenosine monophosphate, which are connected to Extracellular. Her study explores the link between Protein kinase A and topics such as G protein-coupled receptor that cross with problems in Stimulus.
Her work in Phosphodiesterase addresses issues such as Myocyte, which are connected to fields such as Molecular biology and IBMX. Her work in Signal transduction tackles topics such as Signalling which are related to areas like Neuroscience. Manuela Zaccolo interconnects Biosensor, Biophysics, Protein structure and Green fluorescent protein in the investigation of issues within Förster resonance energy transfer.
The scientist’s investigation covers issues in Cell biology, Phosphodiesterase, Calcium, Phosphorylation and Förster resonance energy transfer. Her study in Protein kinase A, Phosphatase, Kinase, Intracellular and Signal transduction is carried out as part of her studies in Cell biology. Manuela Zaccolo has researched Protein kinase A in several fields, including Caveolae and Adrenergic receptor.
Her Signal transduction research includes elements of Oxidative stress and Atrial fibrillation. The various areas that she examines in her Phosphodiesterase study include Brain natriuretic peptide and Cardiac myocyte. Her study in Förster resonance energy transfer is interdisciplinary in nature, drawing from both Biological system, Adenosine monophosphate and Signalling.
Her primary areas of study are Cell biology, Phosphorylation, Phosphodiesterase, Protein kinase A and Contractility. Manuela Zaccolo applies her multidisciplinary studies on Cell biology and Whole cell in her research. Her work deals with themes such as Adenylate kinase, Membrane protein and Effector, which intersect with Phosphorylation.
The study incorporates disciplines such as Muscle hypertrophy and Neurotransmission in addition to Phosphodiesterase. Her Protein kinase A research incorporates elements of Adenosine monophosphate and Förster resonance energy transfer. Her Förster resonance energy transfer research is multidisciplinary, incorporating perspectives in Wild type and Kinase activity.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo;Tullio Pozzan.
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
M Zaccolo;F De Giorgi;C Y Cho;L Feng.
Nature Cell Biology (2000)
Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases
Marco Mongillo;Theresa McSorley;Sandrine Evellin;Arvind Sood.
Circulation Research (2004)
An Approach to Random Mutagenesis of DNA Using Mixtures of Triphosphate Derivatives of Nucleoside Analogues
Manuela Zaccolo;David M. Williams;Daniel M. Brown;Ermanno Gherardi.
Journal of Molecular Biology (1996)
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis.
EMBO Reports (2004)
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Marco Mongillo;Carlo G. Tocchetti;Anna Terrin;Valentina Lissandron.
Circulation Research (2006)
Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation.
A Funaro;G C Spagnoli;C M Ausiello;M Alessio.
Journal of Immunology (1990)
cAMP and cGMP Signaling Cross-Talk: Role of Phosphodiesterases and Implications for Cardiac Pathophysiology
Manuela Zaccolo;Matthew A. Movsesian.
Circulation Research (2007)
The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase.
Manuela Zaccolo;Ermanno Gherardi.
Journal of Molecular Biology (1999)
cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism
Eiki Takimoto;Hunter C. Champion;Diego Belardi;Javid Moslehi.
Circulation Research (2004)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: