His primary scientific interests are in Cell biology, Internal medicine, Endocrinology, Receptor and Second messenger system. The study incorporates disciplines such as Phosphodiesterase and Voltage-dependent calcium channel in addition to Cell biology. His work in the fields of Internal medicine, such as Myocyte, Heart failure, Adrenergic and Muscle hypertrophy, overlaps with other areas such as cGMP-dependent protein kinase.
In the field of Endocrinology, his study on Nitric oxide synthase overlaps with subjects such as Adrenergic beta-Antagonists, Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor. Viacheslav O. Nikolaev has included themes like Carvedilol, Bisoprolol, Conformational change and Förster resonance energy transfer in his Receptor study. His research combines Cell signaling and Second messenger system.
Viacheslav O. Nikolaev spends much of his time researching Cell biology, Internal medicine, Endocrinology, Receptor and Second messenger system. He frequently studies issues relating to Cyclic adenosine monophosphate and Cell biology. His Internal medicine research is multidisciplinary, relying on both Protein kinase A and Cardiology.
His Endocrinology research is multidisciplinary, incorporating perspectives in Phosphodiesterase 3 and Adrenergic. His Second messenger system research incorporates elements of G protein-coupled receptor, Cyclic nucleotide, Förster resonance energy transfer, Phosphodiesterase and Lipid microdomain. His work is dedicated to discovering how Förster resonance energy transfer, Biophysics are connected with Microscopy and other disciplines.
His main research concerns Cell biology, Internal medicine, Phosphodiesterase, Second messenger system and Endocrinology. His Cell biology research is multidisciplinary, incorporating elements of Cell, Adenosine monophosphate, Receptor, Cyclic adenosine monophosphate and Lipid microdomain. His studies deal with areas such as Ca2+/calmodulin-dependent protein kinase and Cardiology as well as Internal medicine.
His Phosphodiesterase research incorporates themes from Roflumilast, Downregulation and upregulation and Forskolin. The concepts of his Second messenger system study are interwoven with issues in Ryanodine receptor, Protein kinase A, Cyclic nucleotide, Guanosine monophosphate and Cgmp signaling. His work carried out in the field of Protein kinase A brings together such families of science as Protein phosphatase 2, Phosphatase and Myocyte.
Cell biology, Second messenger system, Phosphodiesterase, Cyclic adenosine monophosphate and Intracellular are his primary areas of study. Viacheslav O. Nikolaev has researched Cell biology in several fields, including Guanosine monophosphate, Contractility, Lipid microdomain and Förster resonance energy transfer. His work carried out in the field of Phosphodiesterase brings together such families of science as Roflumilast, Downregulation and upregulation, Pharmacology and Cyclic nucleotide.
His work deals with themes such as Rolipram, Cilostamide and Ion channel, which intersect with Cyclic adenosine monophosphate. His studies in Intracellular integrate themes in fields like Cell signaling, NAD+ kinase and Adenine nucleotide. His Phosphatase study incorporates themes from Internal medicine and Ca2+/calmodulin-dependent protein kinase.
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Novel single chain cAMP sensors for receptor-induced signal propagation.
Viacheslav O. Nikolaev;Moritz Bünemann;Lutz Hein;Annette Hannawacker.
Journal of Biological Chemistry (2004)
High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β2-Adrenergic Receptor/Gi–Dependent Manner A New Model of Takotsubo Cardiomyopathy
Helen Paur;Peter T. Wright;Markus B. Sikkel;Matthew H. Tranter.
Circulation (2012)
β2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation
Viacheslav O. Nikolaev;Viacheslav O. Nikolaev;Alexey Moshkov;Alexander R. Lyon;Michele Miragoli.
Science (2010)
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.
Davide Calebiro;Viacheslav O. Nikolaev;Maria Cristina Gagliani;Tiziana de Filippis.
PLOS Biology (2009)
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.
Rachael P. Norris;William J. Ratzan;Marina Freudzon;Lisa M. Mehlmann.
Development (2009)
Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling
Viacheslav O. Nikolaev;Moritz Bünemann;Eva Schmitteckert;Martin J. Lohse.
Circulation Research (2006)
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.
Jean-Pierre Vilardaga;Viacheslav O Nikolaev;Kristina Lorenz;Sébastien Ferrandon.
Nature Chemical Biology (2008)
Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
Yuko Nakagawa;Masahiro Nagasawa;Satoko Yamada;Akemi Hara.
PLOS ONE (2009)
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging
Orie T. Shafer;Dong Jo Kim;Richard Dunbar-Yaffe;Viacheslav O. Nikolaev.
Neuron (2008)
Signaling by internalized G-protein-coupled receptors.
Davide Calebiro;Viacheslav O. Nikolaev;Luca Persani;Martin J. Lohse.
Trends in Pharmacological Sciences (2010)
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