World's Best Scientists 2026 revealed!
Jean-Pierre Vilardaga

Jean-Pierre Vilardaga

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10040
World Ranking
16662
National Ranking
6891

Overview

Jean-Pierre Vilardaga is affiliated with the University of Pittsburgh in the United States. Their research primarily focuses on fields related to biochemistry, genetics, and molecular biology, with additional work spanning medicine.

Their scientific work extensively covers subfields such as molecular biology, oncology, cellular and molecular neuroscience, nephrology, and cell biology.

The main topics addressed in their research include:

  • Receptor Mechanisms and Signaling
  • Protein Kinase Regulation and GTPase Signaling
  • Metabolism, Diabetes, and Cancer
  • Bone health and treatments
  • Parathyroid Disorders and Treatments
  • Neuropeptides and Animal Physiology
  • Ion channel regulation and function

Recent publications by Jean-Pierre Vilardaga include:

  • Structural insights into emergent signaling modes of G protein-coupled receptors, 2020, Journal of Biological Chemistry
  • Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation, 2021, Science Signaling
  • Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation, 2020, Nature Chemical Biology
  • G q/11 -dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR, 2020, Proceedings of the National Academy of Sciences
  • PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism, 2020, Nature Metabolism

Their frequent co-authors comprise:

  • Karina A. Peña
  • Sofya Savransky
  • Alex D. White
  • İvet Bahar
  • Wenhan Chang

Jean-Pierre Vilardaga's work has been published consistently in several notable venues, including:

  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Biological Chemistry
  • IUPHAR/BPS Guide to Pharmacology CITE
  • The FASEB Journal
  • Journal of the Endocrine Society

Best Publications

  • A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.

    Carsten Hoffmann;Guido Gaietta;Moritz Bünemann;Stephen R Adams

  • Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

    Sébastien Ferrandon;Timothy N Feinstein;Marian Castro;Bin Wang

  • Measurement of the millisecond activation switch of G protein-coupled receptors in living cells.

    Jean-Pierre Vilardaga;Moritz Bünemann;Cornelius Krasel;Mariàn Castro

  • Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

    Yalikun Suofu;Wei Li;Wei Li;Frédéric G. Jean-Alphonse;Jiaoying Jia

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.

    Jean-Pierre Vilardaga;Viacheslav O Nikolaev;Kristina Lorenz;Sébastien Ferrandon

  • Retromer terminates the generation of cAMP by internalized PTH receptors

    Timothy N Feinstein;Vanessa L Wehbi;Juan A Ardura;David S Wheeler

  • Altered Selectivity of Parathyroid Hormone (PTH) and PTH-Related Protein (PTHrP) for Distinct Conformations of the PTH/PTHrP Receptor

    Thomas Dean;Jean-Pierre Vilardaga;John T. Potts;Thomas James Gardella

  • PTH receptor-1 signalling—mechanistic insights and therapeutic prospects

    Ross W. Cheloha;Samuel H. Gellman;Jean-Pierre Vilardaga;Thomas J. Gardella

  • Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

    Timothy N. Feinstein;Naofumi Yui;Matthew J. Webber;Vanessa L. Wehbi

  • Endosomal generation of cAMP in GPCR signaling

    Jean-Pierre Vilardaga;Frederic G Jean-Alphonse;Thomas J Gardella

  • Structure and dynamics of the active human parathyroid hormone receptor-1.

    L.H. Zhao;S. Ma;I. Sutkeviciute;D.D. Shen

  • Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.

    Marián Castro;Viacheslav O. Nikolaev;Dieter Palm;Martin J. Lohse

  • Molecular basis of inverse agonism in a G protein-coupled receptor.

    Jean-Pierre Vilardaga;Ralf Steinmeyer;Greg S Harms;Martin J Lohse

  • Real-time optical recording of β1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

    Francesca Rochais;Jean-Pierre Vilardaga;Viacheslav O. Nikolaev;Moritz Bünemann

  • Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex.

    Vanessa L. Wehbi;Hilary P. Stevenson;Timothy N. Feinstein;Guillermo Calero

  • Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

    Makoto Okazaki;Sebastien Ferrandon;Jean-Pierre Vilardaga;Mary L. Bouxsein

  • Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein.

    Jean-Pierre Vilardaga;Monika Frank;Cornelius Krasel;Christian Dees

  • Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.

    Jean-Pierre Vilardaga;Jean-Pierre Vilardaga;Guillermo Romero;Peter A. Friedman;Thomas J. Gardella

  • International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

    Thomas J. Gardella;Jean-Pierre Vilardaga

Frequent Co-Authors

Martin J. Lohse
Martin J. Lohse ISAR Bioscience Institute
Thomas J. Gardella
Thomas J. Gardella Harvard University
Viacheslav O. Nikolaev
Viacheslav O. Nikolaev Universität Hamburg
Patrick Robberecht
Patrick Robberecht Université Libre de Bruxelles
Magali Waelbroeck
Magali Waelbroeck Université Libre de Bruxelles
Francisco Ciruela
Francisco Ciruela University of Barcelona
Dennis Brown
Dennis Brown Harvard University
Masaki Noda
Masaki Noda Tokyo Medical and Dental University
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology or Biochemistry in the USA opens up diverse pathways for further education and career advancement. Many graduates explore specialized online programs that build on their science backgrounds while offering flexible learning options.

For those interested in clinical roles, the best online rn to bsn programs help current registered nurses advance in their careers and take on more responsibility in healthcare settings. If healthcare leadership appeals to you, the online masters healthcare management programs can prepare you for management or administrative positions in hospitals or medical organizations.

Mental health is another rewarding field. Programs like psychiatric np programs train you to become a nurse practitioner specializing in psychiatric and mental health care. Alternatively, for those passionate about diet, wellness, and public health, accelerated nutrition degree online options make it possible to gain credentials and begin working sooner.

These online programs offer flexible, accelerated paths to careers that complement your foundation in biology or biochemistry.

Best Scientists Citing Jean-Pierre Vilardaga

Trending Scientists