World's Best Scientists 2026 revealed!
Laurence J. Miller

Laurence J. Miller

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
22093
World Ranking
3927
National Ranking
1939

Overview

Laurence J. Miller is affiliated with the Mayo Clinic in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, neuroscience, and medicine. Within these broad domains, they focus extensively on molecular biology, cellular and molecular neuroscience, and endocrinology, diabetes, and metabolism.

Their main research topics include receptor mechanisms and signaling, neuropeptides and animal physiology, diabetes treatment and management, lipid membrane structure and behavior, mass spectrometry techniques and applications, peptidase inhibition and analysis, as well as pancreatic function and diabetes.

Notable recent papers authored by Laurence J. Miller cover a range of topics in molecular and cellular biology and endocrinology. These include:

  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists, 2020, Molecular Cell
  • Single-molecule FRET imaging of GPCR dimers in living cells, 2021, Nature Methods
  • Activation of the GLP-1 receptor by a non-peptidic agonist, 2020, Nature
  • Structure of an AMPK complex in an inactive, ATP-bound state, 2021, Science
  • Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins, 2020, ACS Pharmacology & Translational Science

Laurence J. Miller frequently publishes in venues such as the IUPHAR/BPS Guide to Pharmacology CITE, SLAS DISCOVERY, PLoS Biology, Nature Communications, and Frontiers in Endocrinology. These publications collectively indicate sustained engagement with pharmacology, molecular biology, and endocrinology research communities.

  • IUPHAR/BPS Guide to Pharmacology CITE
  • SLAS DISCOVERY
  • PLoS Biology
  • Nature Communications
  • Frontiers in Endocrinology

Collaborative work is a notable element of their research profile. Frequent co-authors include researchers such as Kaleeckal G. Harikumar, Patrick M. Sexton, Denise Wootten, Arthur Christopoulos, and Sebastian G. B. Furness. These collaborations suggest active involvement in interdisciplinary and collective research efforts within the domain of receptor and signaling studies.

  • Kaleeckal G. Harikumar
  • Patrick M. Sexton
  • Denise Wootten
  • Arthur Christopoulos
  • Sebastian G. B. Furness

Best Publications

  • Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

    Terry P. Kenakin;Laurence J. Miller

  • International Union of Pharmacology. XXXV. The Glucagon Receptor Family

    Kelly E. Mayo;Laurence J. Miller;Dominique Bataille;Stéphane Dalle

  • Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas.

    Suresh T. Chari;Dhiraj Yadav;Thomas C. Smyrk;Eugene P. DiMagno

  • Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

    Yi Lynn Liang;Maryam Khoshouei;Mazdak Radjainia;Yan Zhang

  • Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

    Chris de Graaf;Dan Donnelly;Denise Wootten;Jesper Lau

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Dysmotility of the small intestine in irritable bowel syndrome.

    J E Kellow;S F Phillips;L J Miller;A R Zinsmeister

  • Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma.

    Vanda A. Lennon;Vanda A. Lennon;Daryl F. Sas;Daryl F. Sas;Michael F. Busk;Michael F. Busk;Bernd Scheithauer;Bernd Scheithauer

  • Dual pathways of internalization of the cholecystokinin receptor.

    Belinda F. Roettger;Ronald U. Rentsch;Delia Pinon;Eileen Holicky

  • Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

    Yi Lynn Liang;Maryam Khoshouei;Alisa Glukhova;Sebastian G.B. Furness

  • Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

    Cassandra Koole;Denise Wootten;John Simms;Celine Valant

  • Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

    Denise Laura Wootten;John Watson Simms;Laurence J Miller;Arthur Christopoulos

  • Secretin and vasoactive intestinal peptide receptors : Members of a unique family of G protein-coupled receptors

    Charles D. Ulrich;Martin Holtmann;Laurence J. Miller

  • Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor.

    B. F. Roettger;D. Ghanekar;R. Rao;C. Toledo

  • Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.

    Martin H. Holtmann;Elizabeth M. Hadac;Laurence J. Miller

  • GR 38032F (Ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man

    N. J. Talley;S. F. Phillips;A. Haddad;L. J. Miller

  • Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor

    Yi Lynn Liang;Maryam Khoshouei;Maryam Khoshouei;Giuseppe Deganutti;Alisa Glukhova

  • Serine-Arginine Protein Kinase 1 Overexpression Is Associated with Tumorigenic Imbalance in Mitogen-Activated Protein Kinase Pathways in Breast, Colonic, and Pancreatic Carcinomas

    Gregory M. Hayes;Patricia E. Carrigan;Laurence J. Miller

  • Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation.

    Gianfranco Alpini;Charles Ulrich;Stuart Roberts;John O. Phillips

  • 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

    Y.L. Liang;M. Khoshouei;A. Glukhova;S.G.B. Furness

Frequent Co-Authors

Patrick M. Sexton
Patrick M. Sexton Monash University
Denise Wootten
Denise Wootten Monash University
Arthur Christopoulos
Arthur Christopoulos Monash University
Ruben Abagyan
Ruben Abagyan University of California, San Diego
Vay Liang W. Go
Vay Liang W. Go University of California, Los Angeles
H. Eric Xu
H. Eric Xu Chinese Academy of Sciences
Herbert Y. Gaisano
Herbert Y. Gaisano University of Toronto
Karsten Melcher
Karsten Melcher Van Andel Institute
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Laurence J. Miller

Trending Scientists

Recently Published Articles