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Arthur Christopoulos

Arthur Christopoulos

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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
106
Citations
46007
World Ranking
1143
National Ranking
30

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award
  • 2021 - Fellow of the Australian Academy of Science
  • 2017 - Fellow of the Australian Academy of Health and Medical Science

Overview

Arthur Christopoulos is affiliated with Monash University in Australia. Their research spans multiple areas within biochemistry, genetics, molecular biology, and neuroscience, with a focus on molecular biology and cellular and molecular neuroscience as prominent subfields.

The main fields of study covered by Christopoulos include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, key subfields of Christopoulos's work involve:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Spectroscopy

The primary topics of research focus on receptor mechanisms and signaling, neuropeptides, and various aspects of neuropharmacology and molecular regulation:

  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Neuroscience and Neuropharmacology Research
  • Nicotinic Acetylcholine Receptors Study
  • Pharmacological Receptor Mechanisms and Effects
  • Adenosine and Purinergic Signaling
  • Protein Kinase Regulation and GTPase Signaling

Arthur Christopoulos has contributed to numerous publications, including papers in highly regarded scientific journals. Some recent examples include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors, 2023, British Journal of Pharmacology
  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets, 2021, British Journal of Pharmacology
  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists, 2020, Molecular Cell
  • Activation of the GLP-1 receptor by a non-peptidic agonist, 2020, Nature

Frequent co-authors collaborating with Christopoulos include:

  • Patrick M. Sexton
  • Céline Valant
  • David M. Thal
  • Denise Wootten
  • Andrew B. Tobin

The scientist's research output appears regularly in several publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • British Journal of Pharmacology
  • Nature Communications
  • ACS Chemical Neuroscience
  • Biochemical Pharmacology

Arthur Christopoulos has been recognized by the academic community with the following awards:

  • Fellow of the Australian Academy of Science, awarded in 2021
  • Fellow of the Australian Academy of Health and Medical Science, awarded in 2017

Best Publications

  • Fitting models to biological data using linear and nonlinear regression : a practical guide to curve fitting

    Harvey Motulsky;Arthur Christopoulos

  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology

    Jonathan D. Urban;William P. Clarke;Mark Von Zastrow;David E. Nichols

  • Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

    P. Jeffrey Conn;Arthur Christopoulos;Craig W. Lindsley;Craig W. Lindsley

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • G Protein-Coupled Receptor Allosterism and Complexing

    Arthur Christopoulos;Terry Kenakin

  • Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

    Arthur Christopoulos

  • Allosteric modulation of G protein-coupled receptors.

    Lauren T May;Katie Leach;Patrick M Sexton;Arthur Christopoulos

  • Signalling bias in new drug discovery: detection, quantification and therapeutic impact

    Terrence Peter Kenakin;Arthur Christopoulos

  • International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

    Richard R. Neubig;Michael Spedding;Terry Kenakin;Arthur Christopoulos

  • THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors

    Stephen P H Alexander;Arthur Christopoulos;Anthony P Davenport;Eamonn Kelly

  • THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

    Stephen Ph Alexander;Arthur Christopoulos;Anthony Peter Davenport;Eamonn Kelly

  • Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Denise L Wootten;Arthur Christopoulos;Maria Marti-Solano;M. Madan Babu

  • G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

    Evi Kostenis;Graeme Milligan;Arthur Christopoulos;Carlos F. Sanchez-Ferrer

  • The Concise Guide to PHARMACOLOGY 2017/18: Overview

    Stephen P. H. Alexander;Eamonn Kelly;Neil V. Marrion;John A. Peters

  • Emerging paradigms in GPCR allostery: implications for drug discovery

    Denise Laura Wootten;Arthur Christopoulos;Patrick Sexton

  • A simple method for quantifying functional selectivity and agonist bias.

    Terry Kenakin;Christian Watson;Vanessa Muniz-Medina;Arthur Christopoulos

  • Allosteric Modulation of the Cannabinoid CB1 Receptor

    Martin R. Price;Gemma L. Baillie;Adèle Thomas;Lesley A. Stevenson

  • Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

    Yi Lynn Liang;Maryam Khoshouei;Mazdak Radjainia;Yan Zhang

  • Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

    Ron O. Dror;Hillary F. Green;Celine Valant;David W. Borhani

  • Muscarinic acetylcholine receptors: novel opportunities for drug development

    Andrew C. Kruse;Brian K. Kobilka;Dinesh Gautam;Patrick M. Sexton

Frequent Co-Authors

Patrick M. Sexton
Patrick M. Sexton Monash University
Denise Wootten
Denise Wootten Monash University
Peter J. Scammells
Peter J. Scammells Monash University
Meritxell Canals
Meritxell Canals University of Nottingham
Andrew B. Tobin
Andrew B. Tobin University of Glasgow
Debbie L. Hay
Debbie L. Hay University of Otago
Roger J. Summers
Roger J. Summers Monash University
Arthur D. Conigrave
Arthur D. Conigrave University of Sydney
Craig W. Lindsley
Craig W. Lindsley Vanderbilt University

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