Bryan L. Roth

Research.com Recognitions

• 2026 - Research.com Neuroscience in United States Leader Award

Overview

Best Publications

• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

  David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

  5396
  Citations

• Relating protein pharmacology by ligand chemistry

  Michael J. Keiser;Bryan L. Roth;Bryan L. Roth;Blaine N. Armbruster;Paul R Ernsberger

  2502
  Citations

• The Expanded Biology of Serotonin

  Miles Berger;John A. Gray;Bryan L. Roth

  2490
  Citations

• Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

  Blaine N. Armbruster;Xiang Li;Mark H. Pausch;Stefan Herlitze

  2266
  Citations

• DREADDs for Neuroscientists.

  Bryan L. Roth

  2070
  Citations

• Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression

  Grazyna Rajkowska;José J Miguel-Hidalgo;Jinrong Wei;Ginny Dilley

  1913
  Citations

• Predicting new molecular targets for known drugs

  Michael J. Keiser;Vincent Setola;John J. Irwin;Christian Laggner

  1902
  Citations

• Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

  Michael J. Krashes;Shuichi Koda;Chian Ping Ye;Sarah C. Rogan

  1678
  Citations

• Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

  Bryan L. Roth;Douglas J. Sheffler;Wesley K. Kroeze

  1355
  Citations

• Functional Selectivity and Classical Concepts of Quantitative Pharmacology

  Jonathan D. Urban;William P. Clarke;Mark Von Zastrow;David E. Nichols

  1317
  Citations

• Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

  David A. Shapiro;Sean Renock;Elaine Arrington;Louis A. Chiodo

  1249
  Citations

• Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.

  Georgia M. Alexander;Sarah C. Rogan;Atheir I. Abbas;Blaine N. Armbruster

  1101
  Citations

• Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

  Matthew S. Goldberg;Sheila M. Fleming;James J. Palacino;Carlos Cepeda

  1083
  Citations

• Structure of the human κ-opioid receptor in complex with JDTic

  Huixian Wu;Daniel Wacker;Mauro Mileni;Vsevolod Katritch

  1078
  Citations

• H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

  Wesley Kars Kroeze;Sandra J. Hufeisen;Beth A. Popadak;Sean M. Renock

  1065
  Citations

• Structure-based discovery of opioid analgesics with reduced side effects

  Aashish Manglik;Henry Lin;Dipendra K. Aryal;John D. McCorvy

  1014
  Citations

• Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

  Bryan L. Roth;Karen Baner;Richard Westkaemper;Daniel Siebert

  962
  Citations

• Ultra-large library docking for discovering new chemotypes

  Jiankun Lyu;Sheng Wang;Trent E. Balius;Isha Singh

  939
  Citations

• Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

  B L Roth;S C Craigo;M S Choudhary;A Uluer

  927
  Citations

• Automated design of ligands to polypharmacological profiles

  Jérémy Besnard;Gian Filippo Ruda;Vincent Setola;Keren Abecassis

  907
  Citations

• The promise and peril of chemical probes.

  Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  883
  Citations