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Biology and Biochemistry

D-Index
75
Citations
21300
World Ranking
5291
National Ranking
194

Overview

Masoud Vedadi is affiliated with the Structural Genomics Consortium in Canada. Their research primarily focuses on areas within biochemistry, genetics, and molecular biology, with a significant volume of work in molecular biology. Additional subfields include infectious diseases, oncology, ecology, and computational theory and mathematics.

The topics addressed in their publications cover diverse aspects such as ubiquitin and proteasome pathways, cancer-related gene regulation, epigenetics and DNA methylation, protein degradation and inhibitors, RNA modifications and cancer, SARS-CoV-2 and COVID-19 research, and RNA and protein synthesis mechanisms.

Some of the recent papers authored or co-authored by Masoud Vedadi include the following:

  • Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response (2020), published in Nature Communications
  • A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization (2021), published in Nature Chemical Biology
  • The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors (2021), published in ACS Infectious Diseases
  • Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors (2021), published in SLAS DISCOVERY
  • CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding (2022), published in Nature Reviews Chemistry

Frequent collaborators in their research include Fengling Li, C.H. Arrowsmith, Peter J. Brown, Irene Chau, and Dalia Baršytė-Lovejoy.

Masoud Vedadi's publications are commonly found in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Medicinal Chemistry, OPAL (Open@LaTrobe) at La Trobe University, SLAS DISCOVERY, and UNC Libraries.

Best Publications

  • The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

    Frank H Niesen;Helena Berglund;Masoud Vedadi

  • Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

    Masoud Vedadi;Frank H. Niesen;Abdellah Allali-Hassani;Oleg Y. Fedorov

  • A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

    Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  • Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

    Jiajun Zhu;Morgan A. Sammons;Greg Donahue;Zhixun Dou

  • An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

    Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy

  • Recognition and specificity determinants of the human cbx chromodomains.

    Lilia Kaustov;Hui Ouyang;Maria J Amaya;Alexander Lemak

  • Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

    Anja Schuetz;Jinrong Min;Jinrong Min;Abdellah Allali-Hassani;Matthieu Schapira;Matthieu Schapira

  • Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

    Masoud Vedadi;Jocelyne Lew;Jennifer Artz;Mehrnaz Amani

  • A strategy for modulation of enzymes in the ubiquitin system.

    Andreas Ernst;George Avvakumov;Jiefei Tong;Yihui Fan

  • Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin

    Anja Schuetz;Jinrong Min;Tatiana Antoshenko;Chia-Lin Wang

  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

    Wenyu Yu;Emma J. Chory;Emma J. Chory;Amy K. Wernimont;Wolfram Tempel

  • Structural biology of human H3K9 methyltransferases

    Hong Wu;Jinrong Min;Vladimir V. Lunin;Tatiana Antoshenko

  • In situ proteolysis for protein crystallization and structure determination

    Aiping Dong;Xiaohui Xu;Aled M. Edwards;Changsoo Chang

  • Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

    Abdellah Allali-Hassani;Patricia W Pan;Patricia W Pan;Ludmila Dombrovski;Rafael Najmanovich;Rafael Najmanovich

  • Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

    Feng Liu;Dalia Barsyte-Lovejoy;Fengling Li;Yan Xiong

  • Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

    A.K. Wernimont;J.D. Artz;P. Finerty;Y.H. Lin

  • A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

    Mohammad S. Eram;Yudao Shen;Magdalena M. Szewczyk;Hong Wu

  • SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

    Dorothy Yanling Zhao;Dorothy Yanling Zhao;Gerald Gish;Ulrich Braunschweig;Yue Li

  • Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

    Feng Liu;Xin Chen;Abdellah Allali-Hassani;Amy M. Quinn

  • An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

    Derek F. Ceccarelli;Xiaojing Tang;Benoit Pelletier;Stephen Orlicky

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Matthieu Schapira
Matthieu Schapira University of Toronto
Peter Brown
Peter Brown University of Oxford
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Dalia Barsyte-Lovejoy
Dalia Barsyte-Lovejoy Structural Genomics Consortium
Jinrong Min
Jinrong Min Structural Genomics Consortium
Jian Jin
Jian Jin Icahn School of Medicine at Mount Sinai
Stephen V. Frye
Stephen V. Frye University of North Carolina at Chapel Hill
Oleg Fedorov
Oleg Fedorov University of Oxford
Udo Oppermann
Udo Oppermann University of Oxford

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