D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 65 Citations 11,001 239 World Ranking 4089 National Ranking 2051

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • DNA

His primary scientific interests are in Biochemistry, Virology, Treponema, Plasmodium falciparum and Drug discovery. His Biochemistry research focuses on Enzyme, Enzyme inhibitor, Trypanosoma brucei, Transferase and Protein prenylation. He interconnects Kinase, Protein kinase A, Pasteurella multocida, Antigen and Microbiology in the investigation of issues within Virology.

His studies in Treponema integrate themes in fields like Genetics, Peptide sequence, Antibody, Gene and Chancre. His Plasmodium falciparum study combines topics in areas such as Farnesyltransferase and Plasmodium berghei. His Drug discovery research incorporates themes from Druggability, Drug development, Computational biology and Active site.

His most cited work include:

  • Chemical genetics of Plasmodium falciparum. (442 citations)
  • Malaria medicines: a glass half full? (277 citations)
  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. (257 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Biochemistry, Virology, Enzyme, Microbiology and Kinase. His research integrates issues of Molecular biology and Plasmodium falciparum in his study of Biochemistry. The subject of his Plasmodium falciparum research is within the realm of Malaria.

His work investigates the relationship between Virology and topics such as Treponema that intersect with problems in Peptide sequence and Gene. His Kinase study integrates concerns from other disciplines, such as Cryptosporidium parvum, In vitro and Toxoplasma gondii. His work deals with themes such as Infectious disease, Computational biology and Drug discovery, which intersect with Structural genomics.

He most often published in these fields:

  • Biochemistry (34.53%)
  • Virology (21.22%)
  • Enzyme (17.99%)

What were the highlights of his more recent work (between 2015-2021)?

  • Kinase (13.67%)
  • Virology (21.22%)
  • In vitro (9.35%)

In recent papers he was focusing on the following fields of study:

His main research concerns Kinase, Virology, In vitro, In vivo and Protein kinase A. While the research belongs to areas of Kinase, Wesley C. Van Voorhis spends his time largely on the problem of Enzyme, intersecting his research to questions surrounding Microbiology. Wesley C. Van Voorhis has included themes like Pathogen, Antigen, Drug target, Plasmodium and In silico in his Virology study.

His In vivo research is multidisciplinary, incorporating elements of Pharmacology, Toxoplasma gondii and Cryptosporidium. His Protein kinase A study results in a more complete grasp of Biochemistry. His work in Drug discovery addresses subjects such as Computational biology, which are connected to disciplines such as Plasmodium falciparum.

Between 2015 and 2021, his most popular works were:

  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. (257 citations)
  • Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. (59 citations)
  • Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (37 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

Wesley C. Van Voorhis mainly investigates Kinase, Virology, In vivo, Plasmodium falciparum and Protein kinase A. His Kinase research is multidisciplinary, relying on both Antiprotozoal, Apicomplexa and Enzyme. His Virology study incorporates themes from Glycoprotein, Antibody, Intracellular and Antigen.

His In vivo research includes themes of In vitro, Cryptosporidium parvum, Cardiotoxicity, Toxoplasma gondii and Pharmacology. Wesley C. Van Voorhis has researched Plasmodium falciparum in several fields, including DNA ligase, Drug discovery and Active site. Part of his project on Protein kinase A includes research on Biochemistry and Cell biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Chemical genetics of Plasmodium falciparum.

W. Armand Guiguemde;Anang A. Shelat;David Bouck;Sandra Duffy.
Nature (2010)

563 Citations

Malaria medicines: a glass half full?

Timothy N. C. Wells;Rob Hooft van Huijsduijnen;Wesley C. Van Voorhis.
Nature Reviews Drug Discovery (2015)

391 Citations

Genomic-scale prioritization of drug targets: the TDR Targets database

Fernán Agüero;Bissan Al-Lazikani;Martin Aslett;Matthew Berriman.
Nature Reviews Drug Discovery (2008)

316 Citations

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Wesley C. Van Voorhis;John H. Adams;Roberto Adelfio;Roberto Adelfio;Vida Ahyong.
PLOS Pathogens (2016)

257 Citations

Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes

Christopher Mehlin;Erica Boni;Frederick S Buckner;Linnea Engel.
Molecular and Biochemical Parasitology (2006)

233 Citations

Therapeutic intervention based on protein prenylation and associated modifications

Michael H Gelb;Lucas Brunsveld;Christine A Hrycyna;Susan Michaelis.
Nature Chemical Biology (2006)

226 Citations

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

Laxman Nallan;Kevin D. Bauer;Pravin Bendale;Kasey Rivas.
Journal of Medicinal Chemistry (2005)

205 Citations

Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response

Arturo Centurion-Lara;Christa Castro;Lynn Barrett;Caroline Cameron.
Journal of Experimental Medicine (1999)

187 Citations

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics

Michael H. Gelb;Wesley C. Van Voorhis;Frederick S. Buckner;Kohei Yokoyama.
Molecular and Biochemical Parasitology (2003)

175 Citations

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

Gregory J. Crowther;Dhanasekaran Shanmugam;Santiago J. Carmona;Maria A. Doyle.
PLOS Neglected Tropical Diseases (2010)

169 Citations

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