Member of the Association of American Physicians
His primary scientific interests are in Biochemistry, Virology, Treponema, Plasmodium falciparum and Drug discovery. His Biochemistry research focuses on Enzyme, Enzyme inhibitor, Trypanosoma brucei, Transferase and Protein prenylation. He interconnects Kinase, Protein kinase A, Pasteurella multocida, Antigen and Microbiology in the investigation of issues within Virology.
His studies in Treponema integrate themes in fields like Genetics, Peptide sequence, Antibody, Gene and Chancre. His Plasmodium falciparum study combines topics in areas such as Farnesyltransferase and Plasmodium berghei. His Drug discovery research incorporates themes from Druggability, Drug development, Computational biology and Active site.
The scientist’s investigation covers issues in Biochemistry, Virology, Enzyme, Microbiology and Kinase. His research integrates issues of Molecular biology and Plasmodium falciparum in his study of Biochemistry. The subject of his Plasmodium falciparum research is within the realm of Malaria.
His work investigates the relationship between Virology and topics such as Treponema that intersect with problems in Peptide sequence and Gene. His Kinase study integrates concerns from other disciplines, such as Cryptosporidium parvum, In vitro and Toxoplasma gondii. His work deals with themes such as Infectious disease, Computational biology and Drug discovery, which intersect with Structural genomics.
His main research concerns Kinase, Virology, In vitro, In vivo and Protein kinase A. While the research belongs to areas of Kinase, Wesley C. Van Voorhis spends his time largely on the problem of Enzyme, intersecting his research to questions surrounding Microbiology. Wesley C. Van Voorhis has included themes like Pathogen, Antigen, Drug target, Plasmodium and In silico in his Virology study.
His In vivo research is multidisciplinary, incorporating elements of Pharmacology, Toxoplasma gondii and Cryptosporidium. His Protein kinase A study results in a more complete grasp of Biochemistry. His work in Drug discovery addresses subjects such as Computational biology, which are connected to disciplines such as Plasmodium falciparum.
Wesley C. Van Voorhis mainly investigates Kinase, Virology, In vivo, Plasmodium falciparum and Protein kinase A. His Kinase research is multidisciplinary, relying on both Antiprotozoal, Apicomplexa and Enzyme. His Virology study incorporates themes from Glycoprotein, Antibody, Intracellular and Antigen.
His In vivo research includes themes of In vitro, Cryptosporidium parvum, Cardiotoxicity, Toxoplasma gondii and Pharmacology. Wesley C. Van Voorhis has researched Plasmodium falciparum in several fields, including DNA ligase, Drug discovery and Active site. Part of his project on Protein kinase A includes research on Biochemistry and Cell biology.
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Chemical genetics of Plasmodium falciparum.
W. Armand Guiguemde;Anang A. Shelat;David Bouck;Sandra Duffy.
Malaria medicines: a glass half full?
Timothy N. C. Wells;Rob Hooft van Huijsduijnen;Wesley C. Van Voorhis.
Nature Reviews Drug Discovery (2015)
Genomic-scale prioritization of drug targets: the TDR Targets database
Fernán Agüero;Bissan Al-Lazikani;Martin Aslett;Matthew Berriman.
Nature Reviews Drug Discovery (2008)
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
Wesley C. Van Voorhis;John H. Adams;Roberto Adelfio;Roberto Adelfio;Vida Ahyong.
PLOS Pathogens (2016)
Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes
Christopher Mehlin;Erica Boni;Frederick S Buckner;Linnea Engel.
Molecular and Biochemical Parasitology (2006)
Therapeutic intervention based on protein prenylation and associated modifications
Michael H Gelb;Lucas Brunsveld;Christine A Hrycyna;Susan Michaelis.
Nature Chemical Biology (2006)
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Laxman Nallan;Kevin D. Bauer;Pravin Bendale;Kasey Rivas.
Journal of Medicinal Chemistry (2005)
Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response
Arturo Centurion-Lara;Christa Castro;Lynn Barrett;Caroline Cameron.
Journal of Experimental Medicine (1999)
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
Michael H. Gelb;Wesley C. Van Voorhis;Frederick S. Buckner;Kohei Yokoyama.
Molecular and Biochemical Parasitology (2003)
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.
Gregory J. Crowther;Dhanasekaran Shanmugam;Santiago J. Carmona;Maria A. Doyle.
PLOS Neglected Tropical Diseases (2010)
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