World's Best Scientists 2026 revealed!

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Chemistry

D-Index
114
Citations
45549
World Ranking
674
National Ranking
277

Biology and Biochemistry

D-Index
123
Citations
50702
World Ranking
560
National Ranking
355

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1991 - Fellow of Alfred P. Sloan Foundation

Overview

Michael H. Gelb is affiliated with the University of Washington in the United States. Their research spans diverse areas within medicine and biochemical sciences, with a significant focus on lysosomal storage disorders and genetic diseases.

The primary fields of study in their work include Medicine and Biochemistry, Genetics and Molecular Biology, with notable subfields such as Physiology, Molecular Biology, Epidemiology, Organic Chemistry, and Genetics.

Their main research topics cover:

  • Lysosomal Storage Disorders Research
  • Trypanosoma species research and implications
  • Carbohydrate Chemistry and Synthesis
  • Metabolism and Genetic Disorders
  • Neonatal Health and Biochemistry
  • Cellular transport and secretion
  • Erythrocyte Function and Pathophysiology

Frequent coauthors collaborating with Michael H. Gelb include:

  • Xinying Hong (26 publications)
  • Zackary M. Herbst (24 publications)
  • Joseph J. Orsini (16 publications)
  • Hamid Khaledi (13 publications)
  • Francyne Kubaski (11 publications)

Their work is commonly published in several scientific journals, most prominently:

  • Molecular Genetics and Metabolism (43 publications)
  • International Journal of Neonatal Screening (6 publications)
  • Genetics in Medicine (5 publications)
  • SSRN Electronic Journal (5 publications)
  • Molecular Genetics and Metabolism Reports (3 publications)

Notable recent publications include:

  • In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease, 2022, New England Journal of Medicine
  • Toward newborn screening of metachromatic leukodystrophy: results from analysis of over 27,000 newborn dried blood spots, 2020, Genetics in Medicine
  • Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns, 2020, Orphanet Journal of Rare Diseases
  • The critical role of psychosine in screening, diagnosis, and monitoring of Krabbe disease, 2020, Genetics in Medicine
  • Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction, 2020, Neuron

Recognition for their contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2009 and a Fellow of the Alfred P. Sloan Foundation in 1991.

Best Publications

  • Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

    Steven P. Gygi;Beate Rist;Scott A. Gerber;Frantisek Turecek

  • Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction

    Justin B. Siegel;Alexandre Zanghellini;Helena M. Lovick;Gert Kiss

  • Interfacial catalysis: the mechanism of phospholipase A2

    David L. Scott;Steven P. White;Zbyszek Otwinowski;Wei Yuan

  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

    Luc H. Boudreau;Anne Claire Duchez;Nathalie Cloutier;Denis Soulet

  • Biochemistry and physiology of mammalian secreted phospholipases A2.

    Gérard Lambeau;Michael H Gelb

  • Prenyl proteins in eukaryotic cells: a new type of membrane anchor

    John A. Glomset;Michael H. Gelb;Christopher C. Farnsworth

  • Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.

    I. P. Street;Hung-Kuei Lin;F. Laliberte;Farideh Ghomashchi

  • Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm

    Otto G. Berg;Michael H. Gelb;Ming-Daw Tsai;Mahendra Kumar Jain

  • Fluoro ketone inhibitors of hydrolytic enzymes.

    Michael H. Gelb;John P. Svaren;Robert H. Abeles

  • Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue.

    David L. Scott;Zbyszek Otwinowski;Michael H. Gelb;Paul B. Sigler

  • Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

    Robert L Wilensky;Yi Shi;Emile R Mohler;Damir Hamamdzic

  • Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening

    Yijun Li;C. Ronald Scott;Nestor A. Chamoles;Ahmad Ghavami

  • Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

    Sarah Glover;Timothy Bayburt;Mechthild Jonas;Emil Chi

  • Computational protein design enables a novel one-carbon assimilation pathway

    Justin B. Siegel;Amanda Lee Smith;Sean Poust;Adam J. Wargacki

  • Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2

    Alan G. Singer;Farideh Ghomashchi;Catherine Le Calvez;James Bollinger

  • Human Lamin B Contains a Farnesylated Cysteine Residue

    Christopher C. Farnsworth;Sharon L. Wolda;Michael H. Gelb;John A. Glomset

  • Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

    Advait S. Nagle;Shilpi Khare;Arun Babu Kumar;Frantisek Supek

  • Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

    Shao H. Yang;Martin O. Bergo;Julia I. Toth;Xin Qiao

  • Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate.

    David L. Scott;Steven P. White;Jeffrey L. Browning;Joseph J. Rosa

  • Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

    Julia I. Toth;Shao H. Yang;Xin Qiao;Anne P. Beigneux

Frequent Co-Authors

František Tureček
František Tureček University of Washington
Frederick S. Buckner
Frederick S. Buckner University of Washington
Gérard Lambeau
Gérard Lambeau Centre national de la recherche scientifique, CNRS
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
Christophe L. M. J. Verlinde
Christophe L. M. J. Verlinde University of Washington
Martin Sadilek
Martin Sadilek University of Washington
Mahendra Kumar Jain
Mahendra Kumar Jain University of Delaware
Christina S. Leslie
Christina S. Leslie Memorial Sloan Kettering Cancer Center
Teal S. Hallstrand
Teal S. Hallstrand University of Washington
Makoto Murakami
Makoto Murakami University of Tokyo

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