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Biology and Biochemistry

D-Index
77
Citations
20744
World Ranking
4791
National Ranking
130

Overview

Gérard Lambeau is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology, focusing heavily on nephrology and molecular biology subfields along with pulmonary and respiratory medicine, immunology, and public health-related areas.

The scientist has published extensively on topics related to renal diseases and glomerulopathies, as well as vasculitis and amyloidosis, complement system function in diseases, streptococcal infections, gut microbiota and health, and autoimmune bullous skin diseases. These research themes demonstrate a broad interest in immune-related and inflammatory conditions affecting multiple organ systems.

Recent publications by Gérard Lambeau include:

  • The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy (2020, Kidney International)
  • Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy (2020, Journal of Clinical Investigation)
  • Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification (2023, Kidney International)
  • The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron (2022, Science Advances)
  • The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation (2022, JCI Insight)

Their frequent coauthors include Christine Payré, Pierre Ronco, Jack F.M. Wetzels, Manuel Praga, and Franck Bihl, reflecting a collaborative research network exploring various aspects of nephrology and molecular biology.

Publications by Gérard Lambeau appear most commonly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Kidney International
  • Biochimie
  • Journal of Clinical Investigation
  • Kidney International Reports

The main areas of study where Gérard's work is concentrated include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields of study frequently encountered in their work are:

  • Molecular Biology
  • Nephrology
  • Pulmonary and Respiratory Medicine
  • Immunology
  • Public Health, Environmental and Occupational Health

Topics central to their investigations include:

  • Renal Diseases and Glomerulopathies
  • Vasculitis and related conditions
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Complement system in diseases
  • Streptococcal Infections and Treatments
  • Gut microbiota and health
  • Autoimmune Bullous Skin Diseases

Best Publications

  • M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.

    Laurence H. Beck;Ramon G.B. Bonegio;Gérard Lambeau;David M. Beck

  • Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

    Nicola M Tomas;Laurence H Beck;Catherine Meyer-Schwesinger;Barbara Seitz-Polski

  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

    Luc H. Boudreau;Anne Claire Duchez;Nathalie Cloutier;Denis Soulet

  • Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

    Caroline Subra;Caroline Subra;David Grand;Karine Laulagnier;Alexandre Stella

  • Biochemistry and physiology of mammalian secreted phospholipases A2.

    Gérard Lambeau;Michael H Gelb

  • Receptors for a growing family of secreted phospholipases A2.

    Gérard Lambeau;Michel Lazdunski

  • Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins.

    Emmanuel Valentin;Gérard Lambeau

  • Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2

    Alan G. Singer;Farideh Ghomashchi;Catherine Le Calvez;James Bollinger

  • Cloning and expression of a membrane receptor for secretory phospholipases A2.

    G Lambeau;P Ancian;J Barhanin;M Lazdunski

  • Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2

    Rao S. Koduri;Juha O. Grönroos;Veli J.O. Laine;Catherine Le Calvez

  • Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

    Lionel Cupillard;Kamen Koumanov;Marie-Geneviève Mattéi;Michel Lazdunski

  • The Human 180-kDa Receptor for Secretory Phospholipases A2 MOLECULAR CLONING, IDENTIFICATION OF A SECRETED SOLUBLE FORM, EXPRESSION, AND CHROMOSOMAL LOCALIZATION

    Philippe Ancian;Gérard Lambeau;Marie-Geneviève Mattéi;Michel Lazdunski

  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

    Anne-Claire Duchez;Luc H. Boudreau;Gajendra S. Naika;James Bollinger

  • Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells

    Sofiane Bezzine;Rao S. Koduri;Emmanuel Valentin;Makoto Murakami

  • Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparan Sulfate Shuttling and External Plasma Membrane Mechanisms

    Makoto Murakami;Rao S. Koduri;Ayako Enomoto;Satoko Shimbara

  • Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.

    Nicola M. Tomas;Elion Hoxha;Anna T. Reinicke;Lars Fester

  • Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom.

    G. Lambeau;J. Barhanin;H. Schweitz;Janti Qar

  • Lipoprotein-Associated and Secreted Phospholipases A2 in Cardiovascular Disease

    Ziad Mallat;Gérard Lambeau;Alain Tedgui

  • On the Diversity of Secreted Phospholipases A2 CLONING, TISSUE DISTRIBUTION, AND FUNCTIONAL EXPRESSION OF TWO NOVEL MOUSE GROUP II ENZYMES

    Emmanuel Valentin;Farideh Ghomashchi;Michael H. Gelb;Michel Lazdunski

  • Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy

    Barbara Seitz-Polski;Guillaume Dolla;Christine Payré;Christophe A. Girard

Frequent Co-Authors

Michael H. Gelb
Michael H. Gelb University of Washington
Michel Lazdunski
Michel Lazdunski Centre national de la recherche scientifique, CNRS
Christophe Arnoult
Christophe Arnoult Grenoble Alpes University
Makoto Murakami
Makoto Murakami University of Tokyo
Eric Boilard
Eric Boilard Université Laval
Pierre Ronco
Pierre Ronco Sorbonne University
Pierre F. Ray
Pierre F. Ray Grenoble Alpes University
Rolf A.K. Stahl
Rolf A.K. Stahl Universität Hamburg
Nina M. van Sorge
Nina M. van Sorge University of Amsterdam
Kei Yamamoto
Kei Yamamoto University of Tokushima

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