World's Best Scientists 2026 revealed!
Makoto Murakami

Makoto Murakami

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
29784
World Ranking
1924
National Ranking
108

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Makoto Murakami is affiliated with the University of Tokyo in Japan and has a robust research portfolio primarily focused on medical and biochemical sciences. Their work encompasses a wide range of topics within Medicine and Biochemistry, Genetics, and Molecular Biology.

Their main fields of study include Medicine, with 107 publications, and Biochemistry, Genetics and Molecular Biology, with 64 publications. Within these fields, Murakami's subfields of study span Molecular Biology, Immunology, Physiology, Surgery, and Biochemistry.

Murakami's research addresses several important topics, including:

  • Lipid metabolism and biosynthesis
  • Asthma and respiratory diseases
  • Mast cells and histamine
  • Cannabis and Cannabinoid Research
  • Gut microbiota and health
  • Psoriasis: Treatment and Pathogenesis
  • Immune Cell Function and Interaction

They have co-authored extensively with several researchers including Yoshitaka Taketomi, Yoshimi Miki, Yuki Nagasaki, Hiroyasu Sato, and Kei Yamamoto. These collaborations reflect ongoing partnerships in advancing knowledge in related biomedical fields.

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Frontiers in Immunology
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Biomolecules

Recent significant papers authored or co-authored by Murakami include:

  • "Updating Phospholipase A2 Biology," 2020, Biomolecules
  • "Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19," 2022, Nature
  • "Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder," 2020, Cell Reports
  • "Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT," 2020, Cell Reports
  • "Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma," 2022, Cell Metabolism

Best Publications

  • Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

    Makoto Murakami;Hiroaki Naraba;Toshihiro Tanioka;Natsuki Semmyo

  • Phospholipase A2 enzymes

    Ichiro Kudo;Makoto Murakami

  • Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.

    Toshihiro Tanioka;Yoshihito Nakatani;Natsuki Semmyo;Makoto Murakami

  • Regulatory Functions of Phospholipase A2.

    Makoto Murakami;Yoshihito Nakatani;Gen-ichi Atsumi;Keizo Inoue

  • Recent progress in phospholipase A₂ research: from cells to animals to humans.

    Makoto Murakami;Yoshitaka Taketomi;Yoshimi Miki;Hiroyasu Sato

  • The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2.

    Makoto Murakami;Satoko Shimbara;Terumi Kambe;Hiroshi Kuwata

  • The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

    Masayuki Morita;Keiji Kuba;Akihiko Ichikawa;Mizuho Nakayama

  • Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

    Makoto Murakami;Terumi Kambe;Satoko Shimbara;Ichiro Kudo

  • Mammalian non-pancreatic phospholipases A2.

    Ichiro Kudo;Makoto Murakami;Shuntaro Hara;Keizo Inoue

  • Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway.

    Makoto Murakami;Ichiro Kudo

  • Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2

    Makoto Murakami;Karin Nakashima;Daisuke Kamei;Seiko Masuda

  • Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

    Daisuke Kamei;Kiyofumi Yamakawa;Yui Takegoshi;Maya Mikami-Nakanishi

  • Prostaglandin E synthase.

    Makoto Murakami;Yoshihito Nakatani;Toshihiro Tanioka;Ichiro Kudo

  • Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation.

    Gen-ichi Atsumi;Masae Tajima;Atsuyoshi Hadano;Yoshihito Nakatani

  • Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D.

    Yong-Xin Sun;Kazuhito Tsuboi;Yasuo Okamoto;Takeharu Tonai

  • Secreted phospholipase A2 revisited.

    Makoto Murakami;Yoshitaka Taketomi;Hiroyasu Sato;Kei Yamamoto

  • Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

    M. Murakami;I. Kudo;K. Inoue

  • Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.

    Daisuke Kamei;Makoto Murakami;Yoshihito Nakatani;Yukio Ishikawa

  • Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2.

    Noriko Ueno;Makoto Murakami;Toshihiro Tanioka;Ko Fujimori

  • Secretory phospholipase A2.

    Makoto Murakami;Ichiro Kudo

Frequent Co-Authors

Ichiro Kudo
Ichiro Kudo Showa University
Kei Yamamoto
Kei Yamamoto University of Tokushima
Keizo Inoue
Keizo Inoue University of Tokyo
Michael H. Gelb
Michael H. Gelb University of Washington
Ryo Taguchi
Ryo Taguchi University of Tokyo
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
Gérard Lambeau
Gérard Lambeau Centre national de la recherche scientifique, CNRS
Junken Aoki
Junken Aoki Tohoku University
Yukihiko Sugimoto
Yukihiko Sugimoto Kumamoto University

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